GenomeNet

Database: UniProt
Entry: W4X9N8_STRPU
LinkDB: W4X9N8_STRPU
Original site: W4X9N8_STRPU 
ID   W4X9N8_STRPU            Unreviewed;      3104 AA.
AC   W4X9N8;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   05-JUN-2019, entry version 39.
DE   RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE            EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa;
OC   Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668 {ECO:0000313|EnsemblMetazoa:SPU_000082-tr, ECO:0000313|Proteomes:UP000007110};
RN   [1] {ECO:0000313|EnsemblMetazoa:SPU_000082-tr}
RP   NUCLEOTIDE SEQUENCE.
RA   Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y.,
RA   Muzny D.M., Worley K.C., Gibbs R.A.;
RT   "Genome sequencing for Strongylocentrotus purpuratus.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:SPU_000082-tr}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|RuleBase:RU363044};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU363044};
CC   -!- SIMILARITY: Belongs to the helicase family.
CC       {ECO:0000256|RuleBase:RU363044}.
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DR   EMBL; AAGJ04118364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7668.SPU_000082-tr; -.
DR   EnsemblMetazoa; SPU_000082-tr; SPU_000082-tr; SPU_000082.
DR   eggNOG; KOG0987; Eukaryota.
DR   eggNOG; COG0507; LUCA.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR010285; DNA_helicase_pif1-like.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR025476; Helitron_helicase-like.
DR   InterPro; IPR006928; Herpes_teg_USP.
DR   InterPro; IPR003323; OTU_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF14214; Helitron_like_N; 1.
DR   Pfam; PF04843; Herpes_teg_N; 1.
DR   Pfam; PF02338; OTU; 1.
DR   Pfam; PF05970; PIF1; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF54001; SSF54001; 2.
DR   SUPFAM; SSF56219; SSF56219; 1.
DR   SUPFAM; SSF57903; SSF57903; 1.
DR   PROSITE; PS50802; OTU; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU363044};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007110};
KW   DNA damage {ECO:0000256|RuleBase:RU363044};
KW   DNA recombination {ECO:0000256|RuleBase:RU363044};
KW   DNA repair {ECO:0000256|RuleBase:RU363044};
KW   Helicase {ECO:0000256|RuleBase:RU363044};
KW   Hydrolase {ECO:0000256|RuleBase:RU363044};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00146};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007110};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00146};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00146}.
FT   TRANSMEM   2985   3002       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       26     80       PHD-type. {ECO:0000259|PROSITE:PS50016}.
FT   DOMAIN      830    963       OTU. {ECO:0000259|PROSITE:PS50802}.
FT   REGION      159    183       Disordered. {ECO:0000256|MobiDB-lite:
FT                                W4X9N8}.
FT   REGION     1061   1085       Disordered. {ECO:0000256|MobiDB-lite:
FT                                W4X9N8}.
FT   REGION     1305   1329       Disordered. {ECO:0000256|MobiDB-lite:
FT                                W4X9N8}.
FT   COILED     1175   1203       {ECO:0000256|SAM:Coils}.
FT   COILED     1381   1401       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS   1061   1078       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                W4X9N8}.
SQ   SEQUENCE   3104 AA;  358456 MW;  ABBF0F2A35688D16 CRC64;
     MELEIDQFKE VMKEIVDMLY TCDPHNEECC VCKNTIEESE NKATCESCNE HYHVTCMGFL
     CQDLVNEQRL IWICSYCGNN NIAHRLFDKV CIPSHINRYQ PLETVDEVFN DDVLLLTKQN
     DKHKKCRSKK RYFKKCKKII IEPGNQSVKV MKSSEFDTHE HDHLVTQRDS PKQRDQVHSE
     EVGSNEWMKV KSKKAKMLEK IQDRISHSTA KSDSGTGQKK RIINGVVLEP GVTYIGKAMK
     SFYERRKSKK SKRKVDIKLN RDVECQNVLE NNVQMYAEKL LNEYSKCVQS PKSMMSHETK
     LYKENNMKQK QSWADVVGHV QNEIIQEHSI VGSATCSHVF LKQYKGKEQS TFRVCGGAKP
     NDKGKVCDGK TENAGEVKVD KDCKQHVDKS IPMKMFEMKH DSKFHKQSVN TSNVNLEEKQ
     IPNENMSNME QNTLVQCVAL GNFHQGNARF GFYSGKQCVS NSFAAILYSK ITDVSQWQKQ
     DLDKVLNYGN ELYRFIQLSS AINEDFLLIS ELPDQLEAFD VHFKMQCSQS VVGIICGDES
     FLSHFNAVTL KDALHQELDR HDACFCTFGG QTFAIISTQE QYFIFDSHSR DRHGLMTDGG
     TSVILCSSNW EGVYDHILKL AESMGINRNQ TEFELTGIIV NLINSSEITV TEHGDNGHVA
     KDEQDCINVV EGNDGFFLPT DRTDKSNRCV PTNVPDSIEI NEDDCNIIDT ENDRNDCRYF
     ASSFSTDMSD CIEIDDDEDD CIIIDAEHDT NYCKDLFSGA PSDRPDSINI DDVDDDDCMV
     IDTEYITNNY KYFPVHSSEK KKMCARFNIT DTCISSKSDI DTCINIGTPA IISNITGDGN
     CFYRAISLFL TGKEGNHKFL RQKCIQHLLE NSHLFAGCLR YEFVSVKDYV SKNKPDINGE
     WATEVEIAVM AHLLETDILI FSDIYLKWRL YSWNNPGRIV HDSNMGIYLL HVKGVHFDYV
     ESVNCIDSVI DEGKQTKEVT CNKKRSINSE MLKDKSKLSK QYASCATKDE IEETFIPSLS
     GKSEDIFMSK RKRKGDTIHE SVKCAKSKKM SFPKMHRYCK TKEPKLENDE RDKKSASKIP
     SYPSDNCNTM NRGVADVLNK GNVFIGNDPL KIRNEKIVLK KVSIRLVRLS ESEIKNLSFD
     LLKGMKKTQS SANFQGTNIP VKGSTIEFPQ KQIKKENKKS KYKQSLKKRQ QLAKERMKAK
     RKQINDHDAY EDVQNNENYV NDMDGCKFKR DFSDVKKTKM KHKYHCNKTF RDEKKKKIKQ
     KYLSEESFRD EHKQKIKHKY ESNILFRDEH KKKIKLKYES NESFRDEHKK KMKQKIKHDY
     QSNKSFRDEH KKKMKQKIKH DYQSNMLFRD EHKKKIKLKY ESNTLFRDEH KQKIKHKYHS
     NQHYRQRLAE KNKERAGLKK MSFKKLENVL RNFRNVISHG PEYVCCVCLK LLFQSQVLKC
     IKQNYQNKTC MNESYLHICN SHCNENCQLA HSSRGHLWIC FTCHRKLLVN KLPAEASVNS
     LQLHEIPEEL KDLNNLEQHL IARNISFFKL IRLPKGGQNA VHGPVVCVPS NTMKTVNMLP
     PPEREDQLIR VKLKRKISYK GHHEYKFVNK VKVLNGLHYL KKNNKWYSDI SINENWNNSL
     SGEMCGAETN DNDDSIQNFE KQETDDQEAR LNGIQLDTCL QPVDIGQEIL DQHFDDIFCC
     APCEGNNPIA LLRDESNEPK SFPVLFPKGQ PTYHDFRSVR VTLGRYLQNR LMHVDNRFAK
     STDFIFYAQC IYEIQQVLSG VSIALRKTSS KSDTDAPITI KDLKQIDKVQ DILKSDRGFR
     FLKQIRGSPP YWSATQKDLL AMVRQLGIPT WFASFSAADM RWPEVLNTLL MERGDKRKIN
     DLDWTDKCEL LKSNPVTVAR MFDKRFHTFL KNVILSEAHP IGHVIDYFYR VEFQQRGSPH
     THCLFWVKDA PEHGYSSDEE VVSFIDKYIS CKIPSEREDP ELHEIITHVQ QHSKKHSKSC
     KKKGKTCRFN FPRPPSDRTC VLYPKEGNPD EIDSAKQLLE SIKNAVNQEN NYTNVSDLFK
     DCNTTQTEFE NATRLLAKQE ILIKKRDPKD VWINQYNPFL LRAWNANMDL QFVMDVYACV
     RYIVSYISKS EREMGMLLSH AQSEINEGNH DARKSIRQLG NVYMQNREVS AQESVYRVCS
     LRLKECSRKV EFIPVGPNPV RMSLPLHVIQ SRPDDDDDDD RSPWMANKLD RYKARPNGSE
     FDTMCLAKFC ACYRILTASQ VKGTKTSPYL FELKNNSGYI QKRTRSSVAV VRYPRFSKIL
     SPEKYYLSIL QLFLPFSNDE QLKPPQFETY QEFYKTGNVK LQGGNLESVK SIVDKHCKEY
     ERNSRAIEQA ELFMDKFGSP EDAWALLCPE SEKERLENPK NKVEMDEPEC ELDIPDFKHE
     KKNETSSVEF RRHGISKHES NSLIRCLNNE QKEIFYKIRQ WCLEKVNGTE SQPFHVLISG
     GAGTGKSYLI KCIYHEAVRI LGKMMVNPDD ISILKVAPTG IAAFNIEGST IHSALSVPIT
     AKFPYRPLGE EKINTLRNKL GQLQILIIDE ISMVDSKLLY YIHGRLRQIR QSRTDCPFGN
     VSVLAVGDFY QLPPVNGKPL YKESVEQSLW SENFKKVELV EIMRQKEDLA FALLLNRLRV
     KEKKDTLSDA DLSILTSRET GEECEEDMHI YSTNKQVNEW NSRMLHSKCE DIICVKAEDR
     NNSKDNDEIC TEPCKSGQSS LPRNLSIALN ARVMLLKNID TNIGLTNGCI GTVAEIVKRN
     NESKPYCISV KFDSQKIGIQ SIKMYEESMG KNYTRKQFPL KLAYACTVHK VQGMTLNKVV
     VSLKKIFASG HSYVGLSRVT SLSGLTIEDF HPKVIYCDPK IKKHLNDMTN FLETSIAEET
     YDDGLCIMLH NIQGLKQHYV DLQCNPTFLN SDIICLTETW LSDKDDAFEL FLAHFKLYHQ
     SRYNSYSITS DSRQHFKDQS HGGVAVYSKN EFSSRLDIKI DNLEFIAFLI TCPVSVVIAV
     VYRPPTYRMK DFCECLNNLL EELHKVGTKC IVMGDFNDNL LKQSSRIQDL MCNHGYTQHV
     KQSTTEGDTL IDHVYSKGLP LVETQVIPIY YSYHEAIKIK LFHI
//
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