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Database: UniProt
Entry: W4YUY2_STRPU
LinkDB: W4YUY2_STRPU
Original site: W4YUY2_STRPU 
ID   W4YUY2_STRPU            Unreviewed;       484 AA.
AC   W4YUY2;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   31-JUL-2019, entry version 28.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa;
OC   Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668 {ECO:0000313|EnsemblMetazoa:SPU_019631-tr, ECO:0000313|Proteomes:UP000007110};
RN   [1] {ECO:0000313|EnsemblMetazoa:SPU_019631-tr}
RP   NUCLEOTIDE SEQUENCE.
RA   Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y.,
RA   Muzny D.M., Worley K.C., Gibbs R.A.;
RT   "Genome sequencing for Strongylocentrotus purpuratus.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:SPU_019631-tr}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|RuleBase:RU610713}.
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DR   EMBL; AAGJ04006139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7668.SPU_019631-tr; -.
DR   EnsemblMetazoa; SPU_019631-tr; SPU_019631-tr; SPU_019631.
DR   eggNOG; ENOG410IECJ; Eukaryota.
DR   eggNOG; ENOG410XPZT; LUCA.
DR   OMA; ECTALFP; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 2.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007110};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007110}.
FT   REGION       33     55       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      127    151       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   484 AA;  54151 MW;  F0F43C0D081030DA CRC64;
     MSGLHEDDGC IDVQLHNMLN TTKFAGENVE HEPTAAPDTV NNYRPPPKLR DSKGPTTDRI
     FRAIWDLPNS CKESFGIELP LSDFGIEFNS NHQGTGGNVI NLFYSNELGL YPRYEYAAGS
     KSTKTPIPIN GGLPQGAISK DTTRPPDKGR ICPQTEDKVW PLLWLANITQ HLEKSTEDII
     STIPDPNFDG VSVIDWEAWR PQWHDNFDTL AVYQQESIAH VKKMHPEWDN ATVELVAKLE
     WTQGAKLFME STLKLGRTLR PKASWGYYAY PYCFNNKETA NMSCTATAVA TNNDVMWLFN
     ESSSLYPSIY LRPTHTNQKA YVKSKLEEAF RVRDRSGDPQ GVVFSYTRFN YSHTGFFYSL
     ENLNDTILQS AELGVDGVIF WGDNFDDKSA EACSHLQSYI KSALGPTVRM SQEGAESCSK
     RICSGKGRCV GDILKCGGTR RLPAGARRKG TEEGDRGGNV CTCRCFRGWT GKDCSVPVKE
     KLNN
//
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