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Database: UniProt
Entry: W4YZ79_STRPU
LinkDB: W4YZ79_STRPU
Original site: W4YZ79_STRPU 
ID   W4YZ79_STRPU            Unreviewed;       494 AA.
AC   W4YZ79;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   31-JUL-2019, entry version 35.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:SPU_021157-tr};
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa;
OC   Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668 {ECO:0000313|EnsemblMetazoa:SPU_021157-tr, ECO:0000313|Proteomes:UP000007110};
RN   [1] {ECO:0000313|EnsemblMetazoa:SPU_021157-tr}
RP   NUCLEOTIDE SEQUENCE.
RA   Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y.,
RA   Muzny D.M., Worley K.C., Gibbs R.A.;
RT   "Genome sequencing for Strongylocentrotus purpuratus.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:SPU_021157-tr}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC       membrane {ECO:0000256|SAAS:SAAS00569352}; Multi-pass membrane
CC       protein {ECO:0000256|SAAS:SAAS00569352}. Cell membrane
CC       {ECO:0000256|SAAS:SAAS00569391}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00569391}.
CC   -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC       family. {ECO:0000256|RuleBase:RU000687,
CC       ECO:0000256|SAAS:SAAS00978283}.
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DR   EMBL; AAGJ04158003; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EnsemblMetazoa; SPU_021157-tr; SPU_021157-tr; SPU_021157.
DR   eggNOG; KOG3645; Eukaryota.
DR   eggNOG; ENOG410XQGR; LUCA.
DR   OMA; HHEYSAN; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR   GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 2.70.170.10; -; 1.
DR   InterPro; IPR006202; Neur_chan_lig-bd.
DR   InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR   InterPro; IPR006201; Neur_channel.
DR   InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR   InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR   InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR   InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR   PANTHER; PTHR18945; PTHR18945; 1.
DR   Pfam; PF02931; Neur_chan_LBD; 1.
DR   Pfam; PF02932; Neur_chan_memb; 1.
DR   PRINTS; PR00254; NICOTINICR.
DR   PRINTS; PR00252; NRIONCHANNEL.
DR   SUPFAM; SSF63712; SSF63712; 1.
DR   SUPFAM; SSF90112; SSF90112; 1.
DR   PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|SAAS:SAAS00458005};
KW   Cell membrane {ECO:0000256|SAAS:SAAS00458000};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007110};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00081591};
KW   Ion channel {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00458066};
KW   Ion transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00457919};
KW   Ligand-gated ion channel {ECO:0000256|SAAS:SAAS00172123};
KW   Membrane {ECO:0000256|SAAS:SAAS00978300, ECO:0000256|SAM:Phobius};
KW   Postsynaptic cell membrane {ECO:0000256|SAAS:SAAS00081626};
KW   Receptor {ECO:0000256|SAAS:SAAS00172128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007110};
KW   Synapse {ECO:0000256|SAAS:SAAS00103537};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00978734,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00978768,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU000687,
KW   ECO:0000256|SAAS:SAAS00081549}.
FT   TRANSMEM    226    249       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    261    279       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    291    313       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    465    485       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       17    224       Neur_chan_LBD. {ECO:0000259|Pfam:
FT                                PF02931}.
FT   DOMAIN      232    479       Neur_chan_memb. {ECO:0000259|Pfam:
FT                                PF02932}.
FT   REGION      392    425       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    392    412       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   494 AA;  56450 MW;  41EC0082FDF1C06C CRC64;
     MTMSNSTTIR PSSNTENRLI GNLLSQYSRY VRPVFNESTI VYVYYHMRLS RLLQMDERNQ
     ILITAMWLEQ SWIDEYLTWD PKDYDNITAV YIPTTMIWIP DTVLYESADV DKELGNDVML
     TNAKVFSNGT VFWQAPAIFK SSCSLSVTYF PFDQHSCKLQ FGPWAYLGNE VIMKKRADSG
     DFSQLSPNGQ WRLLGMPVEE NLIKYGCCPI PYSDVTFFIN LKRKSLFYVF NLIFPTVFMS
     FVSLLGFYLP PDSGEKVGLN ITSLLSIVFF LLLGAQLLPP TSESISYLGK LFSTIIVIMS
     IETAMSVIIL RLYHLHLPYP PPAWARWLIL DKAAKLLRLK GWHHEYSAND DAAFEVNDYG
     AHDFKASDPF EFDNRKSSME SRAIGESLLH KLDMNPDDVP ESKPKEKQSS QDSDYGSETN
     DDSMGSSIMR IGNYIRRLVN NSRKKEALSA IQQQWIDMCL ILDRVLLFLM MTALALGLFS
     ILSIMSNPAS QNQL
//
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