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Database: UniProt
Entry: W4ZIU5_STRPU
LinkDB: W4ZIU5_STRPU
Original site: W4ZIU5_STRPU 
ID   W4ZIU5_STRPU            Unreviewed;       310 AA.
AC   W4ZIU5;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   30-AUG-2017, entry version 17.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa;
OC   Echinoidea; Euechinoidea; Echinacea; Echinoida; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668 {ECO:0000313|EnsemblMetazoa:SPU_028111-tr, ECO:0000313|Proteomes:UP000007110};
RN   [1] {ECO:0000313|EnsemblMetazoa:SPU_028111-tr}
RP   NUCLEOTIDE SEQUENCE.
RA   Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y.,
RA   Muzny D.M., Worley K.C., Gibbs R.A.;
RT   "Genome sequencing for Strongylocentrotus purpuratus.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:SPU_028111-tr}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; AAGJ04072760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGJ04072761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGJ04072762; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGJ04072763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7668.SPU_028111tr; -.
DR   EnsemblMetazoa; SPU_028111-tr; SPU_028111-tr; SPU_028111.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   OMA; VFILFYQ; -.
DR   OrthoDB; EOG093702RP; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0033179; C:proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007110};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007110};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    257    281       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   310 AA;  34993 MW;  84892F6D0A334DD4 CRC64;
     MFIGNCKRMK AMYVTSYEKQ LTKTCSSVTT GVTIGRSMHI MEEDEGSSSG PRKAKDMKKK
     LSGDRCMGNE IHKFVFILFY QGSQLGMRVK RICEGFRASQ YPCPEDFNER NEMSTGIATR
     LQDLQIVLVQ MDDHRQRLLA SAAVNLSSWF IKVRKLKAIY HTLNMFNFDV TSRCLIGECW
     CPADELGDIR LALQRGTQKS GSSVPSILNR ISTTANPPTY NKTNKFTLAF QELTDAYGVA
     TYREVNPAPF AIITFPFLFG VMFGDAGHGL LLALFGLWLI LKENKLKYSM GNDDPRYVFA
     TLYPDVDVVL
//
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