ID W5AA91_WHEAT Unreviewed; 534 AA.
AC W5AA91;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN ORFNames=CFC21_005937 {ECO:0000313|EMBL:KAF6988393.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EnsemblPlants:TraesCS1B02G126500.1};
RN [1] {ECO:0000313|EMBL:KAF6988393.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF6988393.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [2] {ECO:0000313|EnsemblPlants:TraesCS1B02G126500.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS1B02G126500.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS1B02G126500.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [4] {ECO:0000313|EMBL:KAF6988393.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF6988393.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds specifically and directly to substrates containing
CC either a simple or bipartite NLS motif. Promotes docking of import
CC substrates to the nuclear envelope. {ECO:0000256|PIRNR:PIRNR005673}.
CC -!- SUBUNIT: Forms a complex with importin subunit beta-1.
CC {ECO:0000256|PIRNR:PIRNR005673}.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; CM022212; KAF6988393.1; -; Genomic_DNA.
DR SMR; W5AA91; -.
DR STRING; 4565.W5AA91; -.
DR PaxDb; 4565-Traes_1BS_90427972B-2; -.
DR EnsemblPlants; TraesCS1A02G097400.1; TraesCS1A02G097400.1; TraesCS1A02G097400.
DR EnsemblPlants; TraesCS1B02G126500.1; TraesCS1B02G126500.1; TraesCS1B02G126500.
DR Gramene; TraesCAD_scaffold_013046_01G000200.1; TraesCAD_scaffold_013046_01G000200.1; TraesCAD_scaffold_013046_01G000200.
DR Gramene; TraesCLE_scaffold_015251_01G000100.1; TraesCLE_scaffold_015251_01G000100.1; TraesCLE_scaffold_015251_01G000100.
DR Gramene; TraesCLE_scaffold_068399_01G000100.1; TraesCLE_scaffold_068399_01G000100.1; TraesCLE_scaffold_068399_01G000100.
DR Gramene; TraesCS1A02G097400.1; TraesCS1A02G097400.1; TraesCS1A02G097400.
DR Gramene; TraesCS1A03G0233900.1; TraesCS1A03G0233900.1.CDS; TraesCS1A03G0233900.
DR Gramene; TraesCS1B02G126500.1; TraesCS1B02G126500.1; TraesCS1B02G126500.
DR Gramene; TraesKAR1A01G0065870.1; cds.TraesKAR1A01G0065870.1; TraesKAR1A01G0065870.
DR Gramene; TraesKAR1B01G0107490.1; cds.TraesKAR1B01G0107490.1; TraesKAR1B01G0107490.
DR Gramene; TraesPAR_scaffold_008517_01G000200.1; TraesPAR_scaffold_008517_01G000200.1; TraesPAR_scaffold_008517_01G000200.
DR Gramene; TraesROB_scaffold_025018_01G000100.1; TraesROB_scaffold_025018_01G000100.1; TraesROB_scaffold_025018_01G000100.
DR Gramene; TraesROB_scaffold_078139_01G000100.1; TraesROB_scaffold_078139_01G000100.1; TraesROB_scaffold_078139_01G000100.
DR Gramene; TraesWEE_scaffold_054434_01G000200.1; TraesWEE_scaffold_054434_01G000200.1; TraesWEE_scaffold_054434_01G000200.
DR Gramene; TraesWEE_scaffold_068466_01G000100.1; TraesWEE_scaffold_068466_01G000100.1; TraesWEE_scaffold_068466_01G000100.
DR eggNOG; KOG0166; Eukaryota.
DR HOGENOM; CLU_018084_5_0_1; -.
DR OMA; NAYAQMI; -.
DR OrthoDB; 916229at2759; -.
DR Proteomes; UP000019116; Chromosome 1A.
DR Proteomes; UP000019116; Chromosome 1B.
DR Proteomes; UP000815260; Chromosome 1B.
DR ExpressionAtlas; W5AA91; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF71; IMPORTIN SUBUNIT ALPHA; 1.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..58
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 121..164
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 164..206
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 248..290
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 58619 MW; C6D1CD1F74411DC6 CRC64;
MSLRPNERAE VRRSRYKASV DAEDGRRRRE DQMVEIRKNQ RDANLQKKRR DGFPAGAASA
AGGAPQMGHS SALQQKLEGL PAMVQAVLSD DNAVQLEATT QFRKLLSIER SPPIEEVINT
GVVPRFIEFL TREDYPQLQF EAAWALTNIA SGTSDNTKVV VEYGAVPIFV KLLSSPSEDV
REQAVWALGN VAGDSPKCRD LVLGSGGLFP LLQQLNEHAK LSMLRNATWT LSNFCRGKPQ
PNFEQVKPAL SALQRLIHSQ DEEVLTDACW ALSYLSDGTN DKIQSVIESG VFPRLVELLL
HPSASVLIPA LRTVGNIVTG DDLQTQCVID HQALPCLLNL LTTNHKKSIK KEACWTISNI
TAGNRDQIQA VIQANIIGPL VHLLQGAEFD IKKEAAWAIS NATSGGTHDQ IKYLVAQGCI
KPLCDLLICP DPRIVTVCLE GLENILKVGE AEKNLGAGDV NNYAQMIDDA EGLEKIENLQ
SHDNTEIYEK AVKMLESYWL EEEDEVMPSG DNAQNGFNFG SQQNSVPSGG FNFG
//
