ID W5F232_WHEAT Unreviewed; 507 AA.
AC W5F232;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Fatty acyl-CoA reductase {ECO:0000256|RuleBase:RU363097};
DE EC=1.2.1.84 {ECO:0000256|RuleBase:RU363097};
GN Name=FAR4 {ECO:0000313|EMBL:AMR68894.1};
GN ORFNames=CFC21_069139 {ECO:0000313|EMBL:KAF7062555.1};
OS Triticum aestivum (Wheat).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4565 {ECO:0000313|EMBL:AMR68894.1};
RN [1] {ECO:0000313|EMBL:AMR68894.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:AMR68894.1};
RA Wang M., Wang Y., Wang Z.;
RT "Three wheat fatty acyl-Coenzyme A reductases, TaFAR2, TaFAR3 and TaFAR4,
RT are involved in the biosynthesis of primary alcohols.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAF7062555.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7062555.1};
RX PubMed=29069494;
RA Zimin A.V., Puiu D., Hall R., Kingan S., Clavijo B.J., Salzberg S.L.;
RT "The first near-complete assembly of the hexaploid bread wheat genome,
RT Triticum aestivum.";
RL Gigascience 6:1-7(2017).
RN [3] {ECO:0000313|EnsemblPlants:TraesCS5A02G531300.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Chinese Spring
RC {ECO:0000313|EnsemblPlants:TraesCS5A02G531300.1};
RX PubMed=30115783; DOI=10.1126/science.aar7191;
RG International wheat genome sequencing consortium (IWGSC);
RT "Shifting the limits in wheat research and breeding using a fully annotated
RT reference genome.";
RL Science 361:EAAR7191-EAAR7191(2018).
RN [4] {ECO:0000313|EnsemblPlants:TraesCS5A02G531300.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (OCT-2018) to UniProtKB.
RN [5] {ECO:0000313|EMBL:KAF7062555.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaf {ECO:0000313|EMBL:KAF7062555.1};
RA Zimin A.V., Puiu D., Shumante A., Alonge M., Salzberg S.L.;
RT "The second near-complete assembly of the hexaploid bread wheat (Triticum
RT aestivum) genome.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
CC {ECO:0000256|RuleBase:RU363097}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain
CC primary fatty alcohol + CoA + 2 NADP(+); Xref=Rhea:RHEA:52716,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349, ChEBI:CHEBI:77396, ChEBI:CHEBI:83139; EC=1.2.1.84;
CC Evidence={ECO:0000256|RuleBase:RU363097};
CC -!- SIMILARITY: Belongs to the fatty acyl-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00005928, ECO:0000256|RuleBase:RU363097}.
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DR EMBL; KT963077; AMR68894.1; -; mRNA.
DR EMBL; CM022223; KAF7062555.1; -; Genomic_DNA.
DR STRING; 4565.W5F232; -.
DR PaxDb; 4565-Traes_5AL_DC104F3FE-1; -.
DR EnsemblPlants; TraesCS5A02G531300.1; TraesCS5A02G531300.1; TraesCS5A02G531300.
DR Gramene; TraesCLE_scaffold_006233_01G000400.1; TraesCLE_scaffold_006233_01G000400.1; TraesCLE_scaffold_006233_01G000400.
DR Gramene; TraesCS5A02G531300.1; TraesCS5A02G531300.1; TraesCS5A02G531300.
DR Gramene; TraesCS5A03G1240000.1; TraesCS5A03G1240000.1.CDS; TraesCS5A03G1240000.
DR Gramene; TraesKAR5A01G0423820.1; cds.TraesKAR5A01G0423820.1; TraesKAR5A01G0423820.
DR Gramene; TraesROB_scaffold_003114_01G000400.1; TraesROB_scaffold_003114_01G000400.1; TraesROB_scaffold_003114_01G000400.
DR Gramene; TraesWEE_scaffold_014075_01G000300.1; TraesWEE_scaffold_014075_01G000300.1; TraesWEE_scaffold_014075_01G000300.
DR HOGENOM; CLU_024661_4_1_1; -.
DR OMA; YQFDMAS; -.
DR OrthoDB; 3060211at2759; -.
DR Proteomes; UP000019116; Chromosome 5A.
DR Proteomes; UP000815260; Chromosome 5A.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0102965; F:alcohol-forming long-chain fatty acyl-CoA reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0080019; F:alcohol-forming very long-chain fatty acyl-CoA reductase activity; IBA:GO_Central.
DR GO; GO:0035336; P:long-chain fatty-acyl-CoA metabolic process; IBA:GO_Central.
DR GO; GO:0010345; P:suberin biosynthetic process; IBA:GO_Central.
DR CDD; cd05236; FAR-N_SDR_e; 1.
DR CDD; cd09071; FAR_C; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR026055; FAR.
DR InterPro; IPR033640; FAR_C.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11011:SF71; FATTY ACYL-COA REDUCTASE; 1.
DR PANTHER; PTHR11011; MALE STERILITY PROTEIN 2-RELATED; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF03015; Sterile; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 2: Evidence at transcript level;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516,
KW ECO:0000256|RuleBase:RU363097};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|RuleBase:RU363097}; Membrane {ECO:0000256|RuleBase:RU363097};
KW NADP {ECO:0000256|RuleBase:RU363097};
KW Oxidoreductase {ECO:0000256|RuleBase:RU363097,
KW ECO:0000313|EMBL:AMR68894.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019116};
KW Transmembrane {ECO:0000256|RuleBase:RU363097};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363097}.
FT TRANSMEM 415..433
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363097"
FT DOMAIN 21..324
FT /note="Thioester reductase (TE)"
FT /evidence="ECO:0000259|Pfam:PF07993"
FT DOMAIN 411..507
FT /note="Fatty acyl-CoA reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03015"
SQ SEQUENCE 507 AA; 57235 MW; 2A339D23D4631290 CRC64;
MVDTLSEEKI IGYFKNKSIL ITGSTGFLGK ILVEKILRVQ PDVKKIYLPV RAVDAAAAKD
RVETEVVGKE LFGLLREKHG DWFQSFICEK IVPLAGDVMR EDFGVDSETL RELRVTQELD
VIVNGAATTN FYERYDVALD VNVMGVKHMC NFAKKCPNLK VLLHVSTAYV AGEKQGLVQE
RPFKNGETLL EGTHLDIDTE LKLAKDLKKQ LEADADSSPK SQRKAMKDLG ITRARHFGWP
NTYVFTKSMG EMVLGQLKCD LPVVIVRPSI ITSVQNDPLP GWIEGTRTID TIVIGYAKQN
LTYFLADLNL TMDVMPGDMV VNAMMAAIVA HSSSSLEKTQ SHPEPHAPAV YHVSSSRRNP
APYNVLHEAG FRYFTEHPRV GPDGRTVRTH KMTFLSSMAS FHLFMMLRYR LLLELLHLLS
VLCCGLFGLD TLYHDQARKY RFVMHLVDLY GPFALFKGCF DDVNLNKLRL AMTSNHGSLF
NFDPKTIDWD DYFYSVHIPG VLKHMLN
//
