ID W5J1W7_ANODA Unreviewed; 1389 AA.
AC W5J1W7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Canalicular multispecific organic anion transporter 2 {ECO:0000313|EMBL:ETN57731.1};
GN ORFNames=AND_010688 {ECO:0000313|EMBL:ETN57731.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN57731.1};
RN [1] {ECO:0000313|EMBL:ETN57731.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN57731.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN57731.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC010688-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; ADMH02002218; ETN57731.1; -; Genomic_DNA.
DR STRING; 43151.W5J1W7; -.
DR EnsemblMetazoa; ADAC010688-RA; ADAC010688-PA; ADAC010688.
DR VEuPathDB; VectorBase:ADAC010688; -.
DR VEuPathDB; VectorBase:ADAR2_012033; -.
DR eggNOG; KOG0054; Eukaryota.
DR HOGENOM; CLU_000604_27_1_1; -.
DR OMA; NTMSAMF; -.
DR OrthoDB; 3384185at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR CDD; cd03244; ABCC_MRP_domain2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR PANTHER; PTHR24223:SF458; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659-LIKE PROTEIN-RELATED; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 88..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 935..967
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1027..1056
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 90..363
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 482..706
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 858..1094
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1130..1362
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 440..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1389 AA; 153179 MW; 0FF33FAE0E69394A CRC64;
MEAITRKLPP NPRQNANIFS VLTFWWTIDL FRKGYSKVLE LQDLFRPLEV DKSDALGDRL
EKKWFEQQAG PGRPSLVKAI FKTFWREYGL LGLITIINDI VIRLAQPIFL GWLLMYFRED
TEVSRESAFY YAGAIVLLNA LSVITINQYV LGSFQNGMKV RIAVCSVIYR KALRLSRTAL
GDTAPGKVVN LLSNDVNRFD IVSVFLHSMW SAPLLAIIIG VLLYAEIGIA GLIGMIVIAI
VTPIQSYTGK LTSRFRLQTA LRTDERIRLM DEIISGIQVI KMYAWERPFA KLISHARRLE
LKIVRKSAYV RGLYMTFLLF TTRMALFCTM MAMALLGDEI TAARVFVIAT YYAILANTMS
AMFVRGIAEI AEAMVAMRRL QKFLEYEEKV EEALPDGKAK LLAEFGLNGD AGEKQKLIES
ASQLPANVAV SMRGVTARWG AVRRQDQPTG KKSDGNKEQR NGTAAVTTGE ATLPGPTEED
RWAMEETEAA AQPPTTLANV NIDFRKGILI GVIGPVGAGK SSLLQAILRE LPIESGSIVS
QGKFAYVSQE PWVFAGTVRQ NILFGQPMDK DRYDTVVRAC ALVTDFEQLP DGDRTMIGER
GAALSGGQKA RISLARAVYR RADVFLLDDP LSAVDAHVGK HLFDLCLGPQ GKLGAWKTTR
ILVTHQVHFL KKADWVVVMS EGRVQAQGTP QDLSQSGIDF VELVEKKSNE DEESGVDGGG
DGSVSAFDKR SRRDSRASGR SVGSTSSLTE EEERADAPVQ SNMEGTSRGT VQGSVLINYI
RSGANSVIVM GLLVLFLATQ LAASGADYWV AFWTSQEEKR LFQAAHQNHS AVNDTVAADP
VEGEEYLLST DLCMAIHGAL VSSIFVIAII RSISFYQTSV RASQNLHDSM FNGCVSAPMR
FYDTNPSGRI LNRFSKDMGS VDELLPKATL DASQIILSLI GTIVVTVIVN PMFLIPLGAL
GIVFIFVRRI FLKTSKNIKR LEGITRSPVF SHLAASLAGL PTIRAFGAQN ELIREFDAHQ
DIHTASFYMF ITCSSAFGFA LDLLCLIFVF IVVFSFLVIE QAAFGDRVGL AITQAMALTG
MMQWGIRQSA EVANFMMSVE RLLEYRDLES ERQPPKPQNT GANWPEAGRI EFRNVTYRYF
EGATAVLKEL SFEIQPREKI GIVGRTGAGK SSLIGALFRL AQVEGEILID GVNTANIMLE
QLRSKVSIIP QDPVLFSGTL RRNLDPFEDF PDAALWGALE QVELKELANT PAGLQMAVAA
GGSNFSVGQR QLICLARAIL RNNRILVLDE ATANVDPNTD RLIQDTIRHK FADCTVLTIA
HRLNTIMDSD RVLVMDAGQA VEFGTPHELL QLPLGIFQDM VRATGPAESG RLIQIAEQKH
NAQQQLAAQ
//
