ID W5J3D8_ANODA Unreviewed; 785 AA.
AC W5J3D8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Beta,beta-carotene 15,15'-monooxygenase {ECO:0000313|EMBL:ETN58862.1};
GN ORFNames=AND_009524 {ECO:0000313|EMBL:ETN58862.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN58862.1};
RN [1] {ECO:0000313|EMBL:ETN58862.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN58862.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN58862.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC009524-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR604294-1};
CC Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR604294-1};
CC -!- SIMILARITY: Belongs to the carotenoid oxygenase family.
CC {ECO:0000256|ARBA:ARBA00006787}.
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DR EMBL; ADMH02002111; ETN58862.1; -; Genomic_DNA.
DR AlphaFoldDB; W5J3D8; -.
DR STRING; 43151.W5J3D8; -.
DR EnsemblMetazoa; ADAC009524-RA; ADAC009524-PA; ADAC009524.
DR VEuPathDB; VectorBase:ADAC009524; -.
DR VEuPathDB; VectorBase:ADAR2_004906; -.
DR eggNOG; KOG1285; Eukaryota.
DR HOGENOM; CLU_016472_1_1_1; -.
DR OMA; RDFFAVK; -.
DR OrthoDB; 294919at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR InterPro; IPR004294; Carotenoid_Oase.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR PANTHER; PTHR10543; BETA-CAROTENE DIOXYGENASE; 1.
DR PANTHER; PTHR10543:SF24; CAROTENOID ISOMEROOXYGENASE; 1.
DR Pfam; PF03055; RPE65; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR604294-1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR604294-1};
KW Monooxygenase {ECO:0000313|EMBL:ETN58862.1};
KW Oxidoreductase {ECO:0000313|EMBL:ETN58862.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673}.
FT REGION 56..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 144..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 389
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 445
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 515
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
FT BINDING 775
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR604294-1"
SQ SEQUENCE 785 AA; 86852 MW; 54EF480B7B9F40FA CRC64;
MDVTVEDFCE ETNFSESPCP SPFDANILLN MGFLQINGRF TPHSAHSSAC STRSCSLAAT
PVPPETASSE TGPGPQLTVP DDRDGSSGPG PRARKCSLVT VPTEATKFEI SGRATPVFTW
NPIPTSTNVI YALSETSQQI VFSQLEQEAE TETEGSISGV SSDAESECGE LEHDDATNTV
PRARQSEHKD PAAAAAAAAD RKQQEAPNNN NMYPNCDVNV WLRSCEQEIV QPIEGTVKGT
VPEWLNGSLL RNGPGSLKVG DMMFNHLFDS SALLHRFNIN EGKVTYQCRF LKSDAYKKNT
AARRIVVTEF GTSAVPDPCQ TIFQKVAAIF NKPGANNSDN AMISIYPFGD EFFAFTESPI
IHRIDPETLD TEAKLNVSDY VGIVNHTSHP HVMSDGTVYN LGCSVTKTGP AYTIICFPHG
EGMFENARIV ASVPARWKFH PGYMHTFGIT ENFYVIVEQP LSVSVPTMVV SQIRNKPMAA
ALKWFESQQT YIYLLDRDTG ELRHTYHTDP FFYLHIINQY EQDGHVVLDI CCYKDPAMLN
CMYVETMRDM QNNPDYAKMF RGRPLRFVLP LQKQKSAGGS SSTSSSSKLP RGVSVDDASW
TDMWQHLANG AEKECPADDR QTAGLVLQNL VRLAGTKATA YVMPNRTIFC KPELLCDLGC
ETPRIYYECH LGRPYRYFYA ISSDVDASNP GTLIKVDVVS KSRLTWCEEN VYPSEPIFVP
GPDPQSEDDG VVLAAMVWGR EEENRAGLLV LDAKTFTELG RCEFTTPGPV PKCLHGWFQP
SQPKQ
//
