ID W5J817_ANODA Unreviewed; 1113 AA.
AC W5J817;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE SubName: Full=Sugar transporter {ECO:0000313|EMBL:ETN58924.1};
GN ORFNames=AND_009471 {ECO:0000313|EMBL:ETN58924.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN58924.1};
RN [1] {ECO:0000313|EMBL:ETN58924.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN58924.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN58924.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETN58924.1}.
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DR EMBL; ADMH02002110; ETN58924.1; -; Genomic_DNA.
DR AlphaFoldDB; W5J817; -.
DR STRING; 43151.W5J817; -.
DR VEuPathDB; VectorBase:ADAC009471; -.
DR VEuPathDB; VectorBase:ADAR2_002588; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_312456_0_0_1; -.
DR InParanoid; W5J817; -.
DR OMA; SGFFTHW; -.
DR OrthoDB; 2781817at2759; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051119; F:sugar transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17358; MFS_GLUT6_8_Class3_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044775; MFS_ERD6/Tret1-like.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR NCBIfam; TIGR00879; SP; 2.
DR PANTHER; PTHR48021; -; 1.
DR PANTHER; PTHR48021:SF89; FI02132P-RELATED; 1.
DR Pfam; PF00083; Sugar_tr; 2.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
DR PROSITE; PS50850; MFS; 2.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sugar transport {ECO:0000313|EMBL:ETN58924.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:ETN58924.1}.
FT TRANSMEM 118..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 466..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..553
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 645..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 688..708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 740..759
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 780..800
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 806..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 897..921
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 933..952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 964..985
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 991..1015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1027..1048
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1060..1079
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 120..557
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 647..1083
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 32..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 851..878
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 32..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1113 AA; 122753 MW; 524D8D2ABFC16F34 CRC64;
MINDLHQHLP TIPIPPSSGL RCKIMGNNKM TDEEHHQHAD DQREPSSLDE SEQLTTSNLH
YVQPPCGLSL IGEKQWGAPG VNHRTESDGL RDDRVYDKNG TTIIITKSLH AKGTRMQLLM
SILANLTVLS SGMGLGYSAI TLHALTSKDN PMQMDSSQAS WFASISSIAC PLGGLISGYL
LDRIGRKKTL MLINVLSIVS WTMIAVCSRT NFDQMYTQIL TARVIIGIVI GLVSAPASIY
SAEIATPKLR GRLTVLTSLM IAVGILVIYS MGYCVPDDFR LVAAMAAGIC VVSLLLLFIM
PESPAWLMSK HREEEAERSL KTIRGFGAYQ KQYIPEVQQE LMRLRDNVQA QRRAGKESFA
RLLRQPQVYK PLGIIVGFFG FQQFSGIFVI VVYAAKVSAE ASVTLDPFLC TVLIGVTRVI
ATLLVAYILD TLGRKPPSIF SGIGMLVCMF GLAACIYFPL IEGLRWIPTV LILTYIFTST
LGFLTMPFSM LAELFPQNVR GPASGVTVFF TYLMSFFTIK LYPTMVELVG SSNVFIFFGL
MSLLGVLYVH YFVPETKGKS LQEIEDYFRG VSHCSTPSQQ VEEEDVSSLS AQSVDEGTNS
GWVDKMSGKD ADEMEVALKE QSPSKTANNK MVLTELTRKA AIKQIVMAVV ANITIISSGM
GIGFPSIAMI ELTNSTSSVV LSESNATWFA SITSIMCPFG GLLSGYLLDR IGRKKTLYFI
NFISVVSWAI MSFASRTDST VLFIQLIVAR IIIGIAIGLS STPASVYAAE VAHPNLRGRL
TLLTAFCTAI GMLCIYTLGY VFKNDWRFVC MICGIFTVVS LLTVIPLPES PSWLVSKKRM
EKAERCLKVV RAIKEDNNPE IRAELDALED NIARFRASQT KKSKIEQLKK PEVYKPLAIM
CTFFFFQQFT GIFVIIVYAA SFSIEAGVAI DPFLSAVFVG LTRVVTTVLM SFISDKFGRR
PPALFSGFGM ACCMFGLAYF AVHPVKGTSL SWIPTVLLVA FIFTATLGFL TLPFSMNAEV
YPTKIRGFAS GLTIFFGYTM SFIIIKVYPS LVESIGNANV FIMFGSLSLL GIAFVYFFLP
ETKGRTLEDI ENRFRGVKQS RAEVEMKTIL KPS
//
