ID W5J914_ANODA Unreviewed; 2417 AA.
AC W5J914;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Spectrin {ECO:0000313|EMBL:ETN60461.1};
GN ORFNames=AND_007916 {ECO:0000313|EMBL:ETN60461.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN60461.1};
RN [1] {ECO:0000313|EMBL:ETN60461.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN60461.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN60461.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC007916-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826}.
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DR EMBL; ADMH02001932; ETN60461.1; -; Genomic_DNA.
DR STRING; 43151.W5J914; -.
DR EnsemblMetazoa; ADAC007916-RA; ADAC007916-PA; ADAC007916.
DR VEuPathDB; VectorBase:ADAC007916; -.
DR VEuPathDB; VectorBase:ADAR2_001984; -.
DR eggNOG; KOG0040; Eukaryota.
DR HOGENOM; CLU_000847_0_0_1; -.
DR OMA; FQIAQEE; -.
DR OrthoDB; 2872403at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR CDD; cd11808; SH3_Alpha_Spectrin; 1.
DR CDD; cd00176; SPEC; 13.
DR Gene3D; 1.20.58.60; -; 19.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035825; Alpha_Spectrin_SH3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014837; EF-hand_Ca_insen.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF422; PH_9 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF08726; EFhand_Ca_insen; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00435; Spectrin; 20.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00054; EFh; 2.
DR SMART; SM01184; efhand_Ca_insen; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 20.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 17.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 970..1029
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 2264..2299
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 2307..2342
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 293..320
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 389..458
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 822..892
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1215..1285
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1640..1674
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2417 AA; 278214 MW; F658CCF10175267F CRC64;
MEQFTPKEVR ILESAEDIQE RRDQVLHRYS EFKLETRQKR EKLEDSRRFQ YFKRDSDELE
SWINEKLQAA SEESYRDPTN LQAKIQKHQA FEAEVSAHSN AIVVLDNTGQ EMINQGHFAS
ETIQRRLDEL QRLWELLLSR LAEKGMKLQQ ALVLVQFLRH CEEVMFWIKD KEAFVTADEF
GQDLEHVEVL QRKFDEFQKD MASQEYRVTE VNELADKLLF GGHPERETIT RKKEELNEAW
QRLKQLAILR QEKLFGAHEI QRFNRDADET VAWIAEKDVV LSSDDYGRDL ASVQALQRKH
EGVERDLAAL EDKVAALGTE AGRLCSIHAD HSEQIREKQA EIAAYWQSLT AKAKERKQKL
DESYFLHRFL ADFRDLVSWI NGMKAIISAD ELAKDVAGAE ALLERHQEHK GEIDARVDSF
KLTTEAGRQL LEREHYAAAE VQEKLAALEN DKSSLLVLWE DRRILYEQCM DLQLFYRDTE
QADTWMAKQE AFLANEDLGD SLDSVEALIK KHEDFEKSLA AQEEKIKALD VFATKLIDGQ
HYAADDVAQR RAMLLARRSA LQEKSSIRQQ LLEDSNGLQQ FERDCDETKG WISEKLKFAT
DDSYLDPTNL NGKVQKHTNF EHELTANKSR IEDITATGQT LVERGHYAAD KVNARMQEIV
TLWESLVRAS DKKGCKLQEA SQQQQFNRTV EDIELWLSEV EGQLLSEDYG KDLTSVQNLQ
KKQALLEADV MAHQDRIEGI KVAANKFVES GHFDADNIRS KEGALSKRYA ALAEPMATRK
QRLLDSLQVQ QLFRDLEDEA AWIREKEPVA ASTNRGRDLI GVQNLIKKHQ AVLAEINNHE
NRCAGVISNG EQMLNEQPTS SEEIKLRLDA LKDQWNSLKE KSNQRKQDLE DSLQAHQYFA
DANEAESWMR EKEPIVSNQD YGKDEDSSEA LLKKHEALVS DLEAFGNTIQ ALQEQAKNCR
QQETPVVDIT GKECVMALYD YTEKSPREVS MKKGDVLTLL NSNNKDWWKV EVNDRQGFVP
AAYIKKIDPG LSASQQNLID GHSIAKRQAQ INSQYDNLLA LARERQNKLN ETVKAYVLVR
EAADLATWIK DKESHAQIKD VGEDLEEVEV LQKKFDDFND DLKANEVRLA KLNEIAIQLT
SLGQTEAALK IKTQIQTLNE EWATLQTITQ ERASQLGSAH EVQRFHRDVD ETKDWIAEKE
NALNNDELGK DLRGVQTLQR KHEGLERDLA ALQDKIRQLD ETANRLMQSH PDTAEQTYAK
QKEINEEWQQ VVSKAQQRKE KLLDSYDLQR FLSDYRDLSA WISSMMGLVT SEELANDVTG
AEALIERHQE HRTEVDARAG TFSAFEQFGN ELLQANHYAA PEIQEKIENL AKAREELERA
WTARRLQLDQ NLDLQLYLRD CEQAENWMSA REAFLNAEEV DSKGDNVEAL IKKHEDFDKA
INGHEEKIGA LQVLADQLIA QEHYAGKLID DKRQEVLDRW RHLKEDLIEK RSRLGDEQTL
QQFSRDADEI ENWIAEKLQL ATEESYKDPA NIQSKHQKHQ AFEAELAANA DRIQSVLAMG
SNLIDRNQCS GSEEAVQKRL TQIADQWEYL TQKTTEKSLK LKEANKQRTY IAAVKDLDFW
LGEVESLLTS EDAGKDLASV QNLMKKHQLV EADIHAHEDR IKDMNAQADS LVESGQFDSA
GIQEKRQSIN ERYERIRNLA AHRQARLNEA NTLHQFFRDI ADEESWIKEK KLLVGSDDYG
RDLTGVQNLK KKHKRLEAEL ASHEPAIQAV QEAGEKLMDV SNLGVPEIEQ RLKALNQAWT
ELKGLAATRG QKLDESLIYQ QFLAKVEEEE AWITEKQQLL SVEDYGDSMA AVQGLLKKHD
AFETDFAAHR DRCSDIRDNG QTLVTNNNHH GDSISQRCVQ LDKKLENLQA LATRRKAALL
DNFAYLQFMW KADVVESWIA DKENHVKSEE FGRDLSTVQT LLTKQETFDA GLSAFEHEGI
HNITVLKDQL ISTNHAQSAA ILKRHEDVLS RWQKLREDSV ARKNRLLNIQ DQFRQVEDLF
LTFAKKASAF NSWFENAEED LTDPVRCNSI EEIKALREAH AAFQASLSSA QVDFQALAAL
DRQIKSFEVG PNPYTWFTME ALEDTWRNLQ KIIEERDAEL AKEVHRQEEN DKLRKEFAKH
ANLFHQWLTE TRTSLMDGSG SLEEQFEALC HKANEIRARR GDLKKIEELG ATLEEHLILD
NRYTEHSTVG LAQQWDQLDQ LAMRMQHNLK QQIQARNQSG VSEDSLKEFS MMFKHFDKDK
SGKLNHQEFK SCLRALGYDL PMVEEGQPDP EFEEILNVVD PNRDGQVSLQ EYIAFMISKE
TENVQSFEEI ENAFRAITAS DPRPRPYVTK EELYSNLTKD MADYCVQRMK PYNDPKTGHS
ITGALDYVEF TRTLFQN
//
