ID W5JBX5_ANODA Unreviewed; 947 AA.
AC W5JBX5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Rbm25 protein {ECO:0000313|EMBL:ETN61501.1};
GN ORFNames=AND_006838 {ECO:0000313|EMBL:ETN61501.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN61501.1};
RN [1] {ECO:0000313|EMBL:ETN61501.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN61501.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN61501.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC006838-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; ADMH02001667; ETN61501.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JBX5; -.
DR STRING; 43151.W5JBX5; -.
DR EnsemblMetazoa; ADAC006838-RA; ADAC006838-PA; ADAC006838.
DR VEuPathDB; VectorBase:ADAC006838; -.
DR VEuPathDB; VectorBase:ADAR2_002564; -.
DR eggNOG; KOG2253; Eukaryota.
DR HOGENOM; CLU_009855_0_0_1; -.
DR OMA; DGCVNKK; -.
DR OrthoDB; 55687at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR CDD; cd12446; RRM_RBM25; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 1.20.1390.10; PWI domain; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR002483; PWI_dom.
DR InterPro; IPR036483; PWI_dom_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034268; RBM25_RRM.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR18806; RBM25 PROTEIN; 1.
DR PANTHER; PTHR18806:SF4; RNA-BINDING PROTEIN 25; 1.
DR Pfam; PF01480; PWI; 1.
DR SMART; SM00311; PWI; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF101233; PWI domain; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS51025; PWI; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 854..947
FT /note="PWI"
FT /evidence="ECO:0000259|PROSITE:PS51025"
FT REGION 29..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..639
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 947 AA; 109375 MW; 7964CA2010059C56 CRC64;
MSYHPRPPGT TIVSAGMQYI TPPIVQPLMP ALNQPPPSNN RGGSFRSGAT IGSRPQMYNN
KPPPQPEPVY DGPIVTVFVG NISEKVPDPM IKQILATCGS VINWKRVSTF GFCEYEPAGG
ARAVRLVHDL EVGGKKLVAK VDAKNKALID SFREDENNAE KTNEASEKRG DDDALEAIKQ
ILEDFREELA AAEQQQEEQQ AKQKKMLQTV DIEDGKRDII SKEIGKFRKY TEEEELKKEK
EKERKKREEK RAEEKQRRSV SPRKDKKAAS AAPQPPSSSS SSTTSRRRSR SRSRDRERDR
EREREREQRE RDKERERERE REQRERERER ERERERERDL ERQRERERER DRERERERER
EESKINRNPR DIQKEKEMEE EARERKKTEK KAREKEAAYQ ERLRNWEARE RRKAKDYEKE
REKDRCKEEE REREAKRLKE FLEDYDDERD DPKYYKGREL QRRLSERVRE ADADSKDRNK
EQEELDELKN KIFSGEYDNP TLEFEKAKKE REELYKPKIL IDVNLEQSQQ RERELERERL
REIERQRAKD RERANKERYV LAQASRELAS VDAEPIESDS SGVQDNFSSP MGSAAHSTAT
ASNGPGSGTD GLGNSNHHHG HHHHHHHHHH PHSHHHHQQD GHPQRIAEQR VASAGQHPPH
AGSETRDSFG MMSGGVAGGG LLDDENSRHS IRSNSQHGVP ESPDANSNSG LNSLSDKSSH
HPHHSQLHHH HHQPPPQQST VGPTISLNLN VNAKKKKLEV KDVFNSLDDD TEESNGPKKR
KLVPLEYEDG RGQGDTPTGT ANSTPATGSG TGGSKSSKGK KGNDEPPSRE SIKFHEEKRK
NIKSIIDKIP TEKQDLFSYP LDWTEIDDTI EKKIRPWINK KIIEYIGEPE PTLVDFICSK
VLAGSTPQGI LDDVQMVLDE EAEVFVVKMW RLLIYEVEAK KFGLANG
//
