ID W5JCG0_ANODA Unreviewed; 2184 AA.
AC W5JCG0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=AND_007863 {ECO:0000313|EMBL:ETN60514.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN60514.1};
RN [1] {ECO:0000313|EMBL:ETN60514.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN60514.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN60514.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC007863-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; ADMH02001919; ETN60514.1; -; Genomic_DNA.
DR STRING; 43151.W5JCG0; -.
DR EnsemblMetazoa; ADAC007863-RA; ADAC007863-PA; ADAC007863.
DR VEuPathDB; VectorBase:ADAC007863; -.
DR VEuPathDB; VectorBase:ADAR2_006199; -.
DR eggNOG; KOG0384; Eukaryota.
DR HOGENOM; CLU_000315_8_1_1; -.
DR OMA; NFLMPNK; -.
DR OrthoDB; 5482994at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18666; CD1_tandem_CHD1-2_like; 1.
DR CDD; cd17993; DEXHc_CHD1_2; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR040793; CDH1_2_SANT_HL1.
DR InterPro; IPR025260; CHD1-like_C.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623:SF14; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR Pfam; PF18375; CDH1_2_SANT_HL1; 1.
DR Pfam; PF13907; CHD1-like_C; 1.
DR Pfam; PF00385; Chromo; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01176; DUF4208; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 412..507
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 533..596
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 637..807
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 934..1085
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1209..1286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1588..1629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1737..2184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 390..417
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..185
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..234
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1849..1871
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1881..1911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1914..1970
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1986..2084
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2184 AA; 242555 MW; 4D7E13A9D0BB0D17 CRC64;
MSQTKEDKSD SENESSSDSK SGSSSESESE SGSASSSSSS SDNENEAQNS SLNTSNPGDT
SGTTNNTSTN SDAKGAIAEN GLSDRHRGHQ NHTVVPGLRR SDGEEEENNR VRNNLAERTV
DGNERSRSTD ASGSDSDESA EGDGGKGNQQ NSDSDNSASK PSNTSRQTDD DDDDDDDEDD
EDEDSASAVR INGPQQSIIP TAAAAIAASP DIDEDDDDED DDEDDDDDAG RDEEDGDEDH
HSSKSSYDEQ DYAANQLRRK SARKKAVAAA RKRPTTQPAS KTTKKKKSTN SSRWKSDTSD
ESDGSDGDSE DSVRYNRRKA AAAAAASKKR AATTAAASKA KAKKKKRSGA YSSDDASNSD
DDRKRSATRR KTAVSYKEAS GDEPTDSDDL LEVDQEAEEA AAAAAAEEEK AETIERIIGQ
RRGRKGATGA ITTVYAIEEN GDPNEGATSG KLASGELEEQ YLIKWSGWSY LHCTWESEET
LKEQKVKGLK KLENYVKREA TLQHWRRYQA GPEDIDYYEC QQELQQDLLK SYYNVERIIA
QAAKAEGGEG SDYLCKWESL PYSDSTWEDA SLLRKKWQKK VVEFHEREES RCTPSKYSKA
IHDRPKFRHL KTQPEYLGED RGLKLRDYQM DGLNWLILTW CKKNSVILAD EMGLGKTIQT
ICFLYYLFKS QQLYGPFLCV VPLSTMPAWQ REFAIWAPEM NFVTYLGDVQ SREMIRQYEW
CFDRTKKLKF NAILTTYEIL LKDKTFLGSI SWASLLVDEA HRLKNDDSLL YKALKEFDTN
HRLLITGTPL QNSLKELWAL LHFIMPQRFE TWDSFERNYG NDKSYTELHK ELEPYILRRV
KKDVEKSLPA KVEQILRVEM TSIQRQYYRW ILTRNFDALR KGLKGSANTF LNIVIELKKC
CNHAMLTRPV EFDAQVNQDD VLQQLLKGSG KLVLLDKLLC RLKETGHRVL IFSQMVRMLD
ILAEYLQKRH FSYQRLDGSI KGELRRQALD HFNAEGSTDF CFLLSTRAGG LGINLATADT
VIIFDSDWNP QNDLQAQARA HRIGQKNQVN IYRLVTARSV EENIVERAKK KMVLDHLVIQ
RMDTTGRTVL DKNGGSNTSN PFNKEELSAI LKFGTEELFK EEEDGDEELV CDIDEILRRA
ETRDEAPGMP GDELLSAFNV TTFDFDEDKV GGKPITTPST GKERGGEAGG DDAKDWDEII
PKSYRELVEA EERDREIQDL YLPPRRLATK QSDTAADGKG SKGRNRRKGE EDSDDDSDAS
VGLGGDEDGK TKRSRGRPSN KEKITGFTDA ELRRLIKSYK KFPAPLKRLE AIACDAELQE
KPLSDLRRVA QLLHERCVQT MKEIARETEN EKHLAPSAAA AAAAAADGKR KCARAAYSSK
IGGASFNVKT MMQCVDELQP LDEAIPADPH ERARWQLSFK TRPSHFDVDW NEEDDARLLR
GIYQFGIGSW EAMKMDPSLG LSEKILSNDA NRKPQGKHLQ SRAEYLLKVL RKTLELKRGP
SKPRKQRKPK DTKVAALMHH PIAAASPLAS GTESSVGCSI AATIAAVAAG EDVSMGGATA
CGGGMATAAS SMNNRTITVK IRQQQRQAAA AAAAAGTAGN AKEKKKSKKD KQKESKKDKK
KNTGPMHFTA NNEPCALNIL GDLDPTVFNE CKEKMRPVKK ALKTLDNPDE TLSQEEQLRQ
TRDCLLSIGN QINLCLGEYR DPEKAKEWRS NLWYFVSKFT EFDARKLFKL YKHALKRSEG
GGTSGDGGGS AGECSREATD GAASSSTPAI GSSPMKDGKD TTRNHHQHHH HHQSSGGIPP
PTSPGYGSLG KIKKLSSSSK KDNGHSYERT PGDSPLNAHG SVDGAAGGGG DKSEEERSRS
RRERKEKKRL QLLSGIGGPI VSESAVQQRS RYMAATGTTG PCSSSGGGAN DHGSDSGGKD
EGSSMHSKRR LEEGEYDENS KEYKRLHGDS RNHRDKKWDE YGDRDRMRNV APRSGGPSTP
QGGRGYPDAR DDRGTYLPDP SMDRWRDSSR YGSVSDHKRD RYDGYGSRHT PTGGYHRDRE
RERDRDWERA DRDRDRDRER DRSDRERDRD RGDRSFKDKR RHGPSGVGSY PNSHYGIPPA
GYYPPSDSSA YRSYPVGVYP SGQRPSPGAP LPAVVPGVGI TGSGAGGSAS GGVPVGGLPS
SDYIDNRRGE YDRRPPPAAP NNQS
//