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Database: UniProt
Entry: W5JDA7_ANODA
LinkDB: W5JDA7_ANODA
Original site: W5JDA7_ANODA 
ID   W5JDA7_ANODA            Unreviewed;      3041 AA.
AC   W5JDA7;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   16-JAN-2019, entry version 31.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000313|EMBL:ETN62332.1};
GN   ORFNames=AND_005971 {ECO:0000313|EMBL:ETN62332.1};
OS   Anopheles darlingi (Mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Nematocera; Culicoidea;
OC   Culicidae; Anophelinae; Anopheles.
OX   NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN62332.1, ECO:0000313|Proteomes:UP000000673};
RN   [1] {ECO:0000313|EMBL:ETN62332.1, ECO:0000313|EnsemblMetazoa:ADAC005971-PA, ECO:0000313|Proteomes:UP000000673}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA   Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT   "Combination of measures distinguishes pre-miRNAs from other stem-
RT   loops in the genome of the newly sequenced Anopheles darlingi.";
RL   BMC Genomics 11:529-529(2010).
RN   [2] {ECO:0000313|EMBL:ETN62332.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ETN62332.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23761445;
RA   Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I.,
RA   Loreto E.L., Zaha A., Teixeira S.M., Wespiser A.R.,
RA   Almeida E Silva A., Schlindwein A.D., Pacheco A.C., Silva A.L.,
RA   Graveley B.R., Walenz B.P., Lima Bde A., Ribeiro C.A.,
RA   Nunes-Silva C.G., de Carvalho C.R., Soares C.M., de Menezes C.B.,
RA   Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M., Golenbock D.,
RA   Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA   Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M.,
RA   Guimaraes G.M., Goldman G.H., Padilha I.Q., Batista Jda S.,
RA   Ferro J.A., Ribeiro J.M., Fietto J.L., Dabbas K.M., Cerdeira L.,
RA   Agnez-Lima L.F., Brocchi M., de Carvalho M.O., Teixeira Mde M.,
RA   Diniz Maia Mde M., Goldman M.H., Cruz Schneider M.P., Felipe M.S.,
RA   Hungria M., Nicolas M.F., Pereira M., Montes M.A., Cantao M.E.,
RA   Vincentz M., Rafael M.S., Silverman N., Stoco P.H., Souza R.C.,
RA   Vicentini R., Gazzinelli R.T., Neves Rde O., Silva R.,
RA   Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P., Camargo E.P.,
RA   de Vasconcelos A.T.;
RT   "The genome of Anopheles darlingi, the main neotropical malaria
RT   vector.";
RL   Nucleic Acids Res. 41:7387-7400(2013).
RN   [4] {ECO:0000313|EnsemblMetazoa:ADAC005971-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; ADMH02001489; ETN62332.1; -; Genomic_DNA.
DR   STRING; 43151.ADAR001559-PA; -.
DR   EnsemblMetazoa; ADAC005971-RA; ADAC005971-PA; ADAC005971.
DR   VectorBase; ADAC005971-RA; ADAC005971-PA; ADAC005971.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   OMA; PRHAPYK; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000000673; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 4.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000673};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:ETN62332.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2540   2569       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2581   2601       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2627   2650       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2670   2695       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2715   2737       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2862   2885       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      115    169       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      176    228       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      236    292       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      299    365       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      371    427       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     3000   3027       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   3041 AA;  338235 MW;  EAC67B7437E342C0 CRC64;
     MGDSTMGSVS FLHLGDIVSL YSEGSVSGFL STLGLVDDRV VVCPGAGDLN DPPEKFRDCL
     IKICPMNRYS AQKQFWKAAK QSTTTNTDTS LLKRLHHAAE IEKKQNESEN KKLLGTVVQY
     GSVVQLLHLK SNKYVTVNIR LPALLEKNAM RVYLDANGNE GSWFYIMPFY KLRSAGDNVV
     VSDKVILKPV NANRQNLHVA ATYELPDNPG SKEVNVLNSS TSWKITLFME QRENQEDVLK
     GGDVVRLFHA EQEKFLTMDE YKKHQHVFLR TTGRSSATAA TSSKALWEVE VVQHDSCRGG
     AGHWNSLFRF KHLATGYYLA AEIDEDISRT EKSSSSSHPA GGDSFRLVPV PHSTDIASVF
     ELDSTTITRP EGLVPQSSYV RLRHLCSNTW VHATSVPIDI DDDKPVMSKV GCSAIKEDKE
     AFQLIPVSPV EVRDLDFAND ACKLLLAMST KLENGSISSN ERRSLIALLQ DIVFFIAGQE
     NDQNKSDALD LTINNPNRDR QKLLREQYIL KQLFKILQGP FQETKTNDGP FLRIDELGDP
     KNAPFKNIFR LCYRILKLSQ QDYRKNQEYI AKHFGLMQKQ IGYDILAEDT ITALLHNNRK
     LLEKHITAAE IETFVGLVRK NMQSWQSRFL DYLSDLCVSN KKAIAVTQEL ICKSVLSAKN
     ADILIETFLR EVDDDPLGYL SELERGNREF TEIREVDESI SGGDAAGQGG KDGEGGKRKL
     DEKKRYEVVL MWQNRTQSKS MSRLAQGLKI GRTTDIAILD YYRHQLNLFS NMCLNRQYLA
     LNNLSPHLDI DLILRCMSDK TVPYDLRASF CRLMLHLHVD RDPQEPVTPV KYARLWSEIP
     TVMSINDYDI EKQVDSNKEA VRARFNKTIA FVEDYLCNHV VSKMWFADQD QNKLTFEVVK
     LARDLIYFGF YSFSDLLRLT KTLLNILDCV SSSEADGTGL PTGHIDSEGG VLRRIGDMGA
     VMTSLTLGPI STAIVSPTIQ HRKSVSQLLK EYPLVMDTKL KIIEILQFIL DVRLDYRISC
     LLSIFKREFD ENEQTASSST AQSAAQAAQF IAPPTVIAPA ETPAIPDPPS VPADASQQPD
     ANSSAGDTTS EVSLTLSNTT TELTTSTTTT GSDSTSEGLG TMSSDASADA TTTVKPPSSS
     STSETKSHGS GLPPTAENIN LRQKNIDLES IGYQAEGIFG CTEDTYNPLD LDGQGGRTFL
     RVLLHLIMHE YPALVSGALH LLFRHFSQRH EVLHAFRQVQ LLVSDSDVES YKQIKSDLDV
     LRQSVEKSEL WVYKSKQTDD LLAGGGEGGD GAEGGGTGGT AGGSKGAGEH GGEGSGSGGG
     GAMGKGTGSG STSKGKPELV KQESQLNFDQ GPELNAEQSL EYKKIQQILI RMNKLCVTPI
     GPDGLVKPRK HEQRLLRNVG VHTVVLDLLQ IPYDEKDDYR MNELMRLAHQ FLQNFCLGNQ
     QNQILLHKQL DLFLNPGILE AETVCSIFKD NLNLCNEVSD KVVQHFVHCV EIHGRHVEYL
     KFLQTIIKAE NQFIRKCQDM VMQELVNAGE EVLVFYNDKS SFNYFVEQMR SYSGGTLADP
     SPLMYHIELV KLLACCTMGK NVYTEIKCNS LLALDDIVAM ISHPDCIPEV KVAYVDFLCH
     CYIDTEVEVK EIYSSNHMWC LFEKSFLIDI NNVVKGGSFT NRQLENYVCN EVMNILTTFF
     NSQFSDQSTA LQKRQLIFVK ILQNSFKLTQ CKWLSPSQRF NVENCIRTLS EKAKPRGIAI
     PIDLENQVVK MFNKTAMLSR QTSKWLLVTK QTKMERSQSQ IMRMDRSIIE GLQDIVSLLE
     DKLKPLVEAE QSLLVDILYR SELLFPLNTE SRKKCETGDF IRHLIKHTEK LLEEKEEKLC
     VKILKTLKEM MTIDCDYGDK GDHLRTILLK RYFGHEFSLQ PAATAAVAGL PGAVGTVASS
     VHVALLQPAI VGGTGGTASS PMASVSHGPG AKYLIRAGRT LHEVQNHLDK EGASDLVIEL
     VIKSINSPSI FVEAIELGIA LLEGGNPIIQ KGMYNKFLSN DLSQSFFKVF FDKMKDSQQE
     IKSTVTVNTS DMAANKASES KVEGKDIDKI GQRKSLNKVN GIVITEDFKE ELQNAALMTQ
     QSYINARSLA TTSSADGTGS DNGDESLLMS IGSSALEDIL AEKLEKHKDK DENNKLSNKV
     LVMQPILRFL QLLCENHNPE LQNLLRNQNN KTNYNLVSET LMFLDCICGS TTGGLGLLGL
     YINENNVSLI NQTLETLTEY CQGPCHDNQN CIATHESNGL DIITALILND INPLGKNRMD
     LVLELKNNAS KLLLAIMESR GDSENAERIL ANMNPKQLVD VACRAYHQDE NILMLLNQSE
     GSGGTGGAGG MGSGGGGGGV GAGGDGDGYG SLRQDLGDDG HDDDDVGVSP KEVGHNIYIL
     CHQLAQHNKE LAGLLKIDTY STSTPATSGG AGGLAAVAAS STATAAASAA SKANSKTNQA
     LLYYQTHTAQ IEIVRHDRTL EQIVFPIPEI CEYLTKDTKV RVLNTAERDD QGSKVADFFD
     RHEAMFNEMK WQKKLRGQPA LFWVSSYMSL WSNILFNLAV LINLIVAFFY PFENAVPELS
     FHLSSLIWIV MLVSLAIVIT LPRQSGIRTF VVALILRLIF SCGPEPTLWL LGCITVVMKG
     VHIISLMGNY GTLEKHLFSI LTDAELLYHF FYLLFCVFGV LLHPFFFSIL LFDVVYREET
     LLNVIRSVTR NGRSIILTAV LALILVYMFS IIGYMFFRDD FLVPVDEEFS PPSAPPLPSA
     DGMDCTAGES VTGGSHMVPG PDIVGEVIQQ TCSRARITEQ ASTVGGDSGG DGEMKERGCD
     SMIMCIITTM NQGLRNGGGI GDILRAPSRK ETLFVPRVVY DLLFFFIVII IVLNLIFGVI
     IDTFADLRSE KQQKELILKN TCFICGLNRS AFDNKTVSFE EHIKNEHNMW HYLYFIVLVK
     VKDPTEFTGP ESYVHAMVKA NIQDWFPRLR AMSLAAVDGD GEQIELRSLK NLLETNHVAV
     RELMAQIMEL ENKMTEQRKQ RQRHALLNPT TSTSYQFYPQ L
//
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