ID W5JF07_ANODA Unreviewed; 1893 AA.
AC W5JF07;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Rap gtpase-activating protein {ECO:0000313|EMBL:ETN61908.1};
GN ORFNames=AND_006426 {ECO:0000313|EMBL:ETN61908.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN61908.1};
RN [1] {ECO:0000313|EMBL:ETN61908.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN61908.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN61908.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC006426-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; ADMH02001599; ETN61908.1; -; Genomic_DNA.
DR STRING; 43151.W5JF07; -.
DR EnsemblMetazoa; ADAC006426-RA; ADAC006426-PA; ADAC006426.
DR VEuPathDB; VectorBase:ADAC006426; -.
DR VEuPathDB; VectorBase:ADAR2_009542; -.
DR eggNOG; KOG3686; Eukaryota.
DR HOGENOM; CLU_002127_2_0_1; -.
DR OMA; EWFFQTM; -.
DR OrthoDB; 25782at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF70; RAP-GAP DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF21022; Rap-GAP_dimer; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673}.
FT DOMAIN 692..909
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 1047..1123
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 41..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1363..1471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1551..1604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1666..1708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1774..1818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1843..1877
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 42..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1205..1226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1239..1267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1282..1342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1374..1471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1560..1577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1590..1604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1893 AA; 202440 MW; 9F20A62276EAF5EA CRC64;
MISLAEVGGG PAPPLMNGGG PTATLPQLMQ TPIVAGAGVA MMGHQQQQQQ QQQQQQQQQH
HQQQPHHPQQ HPPGSRLVGA GSHQLPPSGM HHTSQQQQQP PNGAHPGTTS TPASHNRASA
RERTMHAVEY YRSNVRRARV DAGLARNSLH ERYSYAQRQM INGGAGITLG VGSTKLSPHS
HADHLYRSNS SLELIHDHHN GSGVVGGGPG QDHLLPGGVG AGGTNLRREY GSHGSIDVIS
SDRHHNHHAH HHHHGGGPPA GSVGENFLTM LQDYQPFGLD GSSLLYSINK QHGHSHVTSN
GGSSTGAVAN GTGAGAGDDV VDRGGNASPK LRNKFHRLWS SSTSTSNGGS GAASKQSRQG
VANASAAAAA AAGAASLDDS QLCMALNAST SSTSTTVSSA DIEERQRRRA FAHFDCRSLT
ANLGYAAKLR GFLLERRRNT TTGASAAATY GTRSSTPDGE GVDEDYGDGQ QNELLENCPF
FRNEIGGEEE REVSLTRMQG SGTSSGMTTA GGGSTAVGST NQRRAIHRPA LAYGVSVLEC
GPNDTLWKGN TCPYQRGIRP IEQIDNGALY YRQYFFGQEH QNWFGMDEHL GPVAISIKRE
KLQPNPTQTL ALHGSDVAPT TTHPSEQYLY RLIVRTSELL TLRGSVIEDS IPNGRGSGKH
VNTKEILEYV APEVQINCLR LAVSTAQCEQ QLLKLDEQGL TNKYKVGILY CRAGQSSEED
MYNNEEAGPA FNEFLDTIGK RIRLKGFEHY KAGLDNKTDS TGTHSLYATH QDCEIMFHVS
TMLPFTPNNR QQLLRKRHIG NDIVTIVFQE PGAQPFTPKN IRSQFQHVFI IVRAVQPCTE
HTQYRVAVSR SKDVPVFGPP VRAGSHFPRG KAFAEFLLAK VINAENAAHR SVKFAMMAIR
TRQEYLKDLA TNYCTATVVE TGQRFSIFPS KKRERTTKPR FSGDLSQRGA FCWQVVLHDS
GQSTQVDCFL GISAETFVLI EECTRQIIFV TPCKAILGWS TSQNSLRVYY HQGECVTLNM
RDTGDRDEQL EVIERLRAVT NGCGALELSL RRNPMGQLGF HVQPDGVVTQ VEISGQAWAA
GLRQGYRLVE ICKVAVATLS HDQMVDLLKT SAQVTVTVIE SFADFAPRRG CTLQNCRFNS
INYENDYESM MLVEPGGVGV GGIGSKNGSS NGGIGGNGRD SKKGLPGGQL QSSASHRRRY
ERNFSPPRSS NSSGYGTGSS SRSFTAGGGV GAAGQQVLPG AGSNGTTNGG DMMGTLTSSS
SGHSSNDERW YDVLDPPQES PSSMMAAPQP QPNGDIQSPN YHHPKLTASS NSLPLSGSSP
RPLSVHTENG SRGSSHALNT ARDNNSANVA LLKRLIIADS PNGGGCAAPG GDGHITTAQQ
QQQLHLVQQQ QAGGQLPPEP LYSSSLKNLS NHHLSTTAEE ENLSRHNSPQ LRRSATTTNI
YGINGKKGTA SGSSASSSRN NSPRPNGETA TKLRTSAMKG QNAGLHHPQR NSVNYTGSTL
QEDLMKLINP DYIANDDNFN AGGGMERMQK GHQNSHSLGN IASLAAAGGL KPIPQKSRSR
EGINLGSSNQ QLSTVNGGGG AGGLKLANGN NGGSGGTNSP SVASGEEDVI FTTARPATVV
SSNSSSPASE LLLLGQKHHL NEDHLKLSPS RKQQLQYGSG GILKNGGAGS GGNGGGLMLP
PAAPAPPQTN GTTTATTNGG GKIPLPDMKE MDWSSLVDTA TKAMTQLSET VKSHPGSSVY
YDDISQVLNG VHHIQQQQQQ QQQQLQQLQH QQTLLNGGTG GSSISGTGSS IGSGADLSSS
TPSSASPVST GSSSAQQQAL MALQNSSSLP ELQCQVSQLS DRVLREQRRR RSLEHAVRKL
TEENRRLQDE SMAAVQQLRR FTEWFFQTID RQS
//
