ID W5JF46_ANODA Unreviewed; 493 AA.
AC W5JF46;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Sorting nexin {ECO:0000313|EMBL:ETN62992.1};
GN ORFNames=AND_005305 {ECO:0000313|EMBL:ETN62992.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN62992.1};
RN [1] {ECO:0000313|EMBL:ETN62992.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN62992.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN62992.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC005305-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; ADMH02001328; ETN62992.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JF46; -.
DR STRING; 43151.W5JF46; -.
DR EnsemblMetazoa; ADAC005305-RA; ADAC005305-PA; ADAC005305.
DR VEuPathDB; VectorBase:ADAC005305; -.
DR VEuPathDB; VectorBase:ADAR2_009100; -.
DR eggNOG; KOG3784; Eukaryota.
DR HOGENOM; CLU_041342_0_0_1; -.
DR OMA; RRHCVGV; -.
DR OrthoDB; 5487301at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd13337; FERM-like_C_SNX17; 1.
DR CDD; cd06885; PX_SNX17_31; 1.
DR Gene3D; 1.20.80.60; -; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR048763; SNX17-31_FERM_F1.
DR InterPro; IPR048767; SNX17-31_FERM_F2.
DR InterPro; IPR037831; SNX17/27/31-like.
DR InterPro; IPR040842; SNX17/31_FERM.
DR InterPro; IPR037836; SNX17_FERM-like_dom.
DR PANTHER; PTHR12431:SF14; LD15323P; 1.
DR PANTHER; PTHR12431; SORTING NEXIN 17 AND 27; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF21273; SNX17-27-31_F1_FERM; 1.
DR Pfam; PF21271; SNX17-31_F2_FERM; 1.
DR Pfam; PF18116; SNX17_FERM_C; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1..109
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 387..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 55987 MW; 76225BA5825363A9 CRC64;
MHFSIPSTQE FGSEGGGSSF TGFNIHINGS FHCCLRYKQL HSLHEQLKRS LPSMVLPSFP
PKKLLSLTPN QIEQRRLSLE RYIQLVGQDP VLCRSELLRA FLLNAQQESS FTECNEVTLD
VYLMNGYRIA ATVYSTDSTA KVLAKATALI DLPFERLCYF ALYLMRIEAT GELTIVKRLM
DFEAPYISQK QWDGCRLVLR TGYWDPCYDV ELMRDRIALN LLYMQALSDV KRGWVVTTRD
LAEQLTNLQA RGNKSEYLEI VRKLPLYGCL QFPRACVDFP EPNTVATVAL GNKELNLLSC
VDEGKEMQET KFKVTRIRCW RVTPIHATEE QSTNGHQTHP STIVGMELSF EYLMAKNQLK
WITIYSEQSM LMSVCLQSIV DELLNQKNGS DPTHLPTPPH TEYAPPLSYI RRDGSNHGMT
DSSSTDTLSN VAHSDTTSNC TSTQSNNHST NTTTNGSSFI RRKLKELNTT VRFRSGRDSV
HNEAFEWIGD DDL
//
