ID W5JIV1_ANODA Unreviewed; 1097 AA.
AC W5JIV1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Alanyl aminopeptidase {ECO:0000313|EMBL:ETN62815.1};
GN ORFNames=AND_005486 {ECO:0000313|EMBL:ETN62815.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN62815.1};
RN [1] {ECO:0000313|EMBL:ETN62815.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN62815.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN62815.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC005486-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M1 family.
CC {ECO:0000256|ARBA:ARBA00010136}.
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DR EMBL; ADMH02001370; ETN62815.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JIV1; -.
DR STRING; 43151.W5JIV1; -.
DR EnsemblMetazoa; ADAC005486-RA; ADAC005486-PA; ADAC005486.
DR VEuPathDB; VectorBase:ADAC005486; -.
DR VEuPathDB; VectorBase:ADAR2_006157; -.
DR eggNOG; KOG1046; Eukaryota.
DR HOGENOM; CLU_003705_2_2_1; -.
DR OMA; SKIWRRE; -.
DR OrthoDB; 3085317at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.25.50.20; -; 1.
DR Gene3D; 2.60.40.1910; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR InterPro; IPR045357; Aminopeptidase_N-like_N.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR024571; ERAP1-like_C_dom.
DR InterPro; IPR014782; Peptidase_M1_dom.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR PANTHER; PTHR11533:SF302; AMINOPEPTIDASE N-LIKE PROTEIN; 1.
DR PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR Pfam; PF11838; ERAP1_C; 1.
DR Pfam; PF01433; Peptidase_M1; 1.
DR Pfam; PF17900; Peptidase_M1_N; 1.
DR SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:ETN62815.1};
KW Hydrolase {ECO:0000313|EMBL:ETN62815.1};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000313|EMBL:ETN62815.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 104..283
FT /note="Aminopeptidase N-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17900"
FT DOMAIN 422..634
FT /note="Peptidase M1 membrane alanine aminopeptidase"
FT /evidence="ECO:0000259|Pfam:PF01433"
FT DOMAIN 757..1072
FT /note="ERAP1-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11838"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1097 AA; 123061 MW; 5FF116B88A946F46 CRC64;
MTEPDSDDDA FLTGGDSSSR PVRDGVAVCS QKRALLVTAI VLGTLLATAL VIAYAGPQTV
CPCAGKIPPG YVPDGYNSSE PFQPIATNGQ PFPWLLPTLP NNVKPNRYIL TIHPNLTTLD
VKGQVSIELY VEKETNFVVL HAQDLNITEK ALVGPKGFAL KILRMLEYTP RQQLYIETRE
KLRKKANYTL SIRWHSKMIL DQFEGDFDMK KTLAATVLKP GSTRKAFPCF DEPHLRAAFK
ISLFRDRFHI GLSNSIVQDT DDVGFYMGTG LLRDDFAETP PLPPDSVSWV ISDFKRELLE
PSSKYQRVNA SKATDGTAIT KPNVPAAVPK VASKSEKKPF RNLTAVLLSK NLFKLTNNLP
TKEPAAEEIN VVTTHPIDSS TASLLGDERE MMWAGETSLI RTAPAYSFYA PETHIAKGTF
ILHTSRDILE YLQQWLSVAY PLSKLDFVAL PSLLDDLSSS LGLIVCRTSF LNEPNSISAK
EYHMSVVKIS EGIVKQYFGG LISPKAWKHK WLWEGLIRYL SRFLLSTIQP LWPMKELFLI
DTLTKALDID ALQGWDSISA GASDTGDNDP FFVDKSASLL SMLQSAIGER NFRQCLGKFL
RTYQFQTAEP ADLWVLCAKQ VNNSRYIKEM MIQWTNAAAF PLLNVTLNGT SLTVHQTDFR
PAEYLAIYDE PIEEIEGDDT PGGRSTTTST TTTTTIAPTG DTKAGSRWIF PIHYTTDVLN
GNGTTPEDME QHEQQPSLSV WLNSSEAVIT LNHSPEWVKL NYGQTGYYRV LYDETNLNKL
VNQLHTNNEV FSTQDRVGLV SDIFTLCHAN LIPCHAAMEL ISYFPKEKEW GPIALGTNHL
EKWRKILKYS ECYLVLAEYV RQNLAKSIQT IGWEDAGEEE IKLLRPVLML SATLWEESDT
IKFAKSLVSN FTANSVPIPP NLRSVAYIGS VLSGEFQYWQ FCWDRYMAVR RERSSVLEER
MELLRALGVT KDAWLQNRLL SHVITLPVFE IVQVLDAIAG TPTGGAMACR FLQAKWFDFQ
SKLGRGTVQF ARVISAITQY GSTKFDYDEL KSLVNRFGDG PGLKLLNMTL STVAANVEWV
SRSQASIYSW IENKYHF
//
