ID W5JME3_ANODA Unreviewed; 762 AA.
AC W5JME3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Cullin {ECO:0000313|EMBL:ETN65547.1};
GN ORFNames=AND_002685 {ECO:0000313|EMBL:ETN65547.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN65547.1};
RN [1] {ECO:0000313|EMBL:ETN65547.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN65547.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN65547.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC002685-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
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DR EMBL; ADMH02000631; ETN65547.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JME3; -.
DR STRING; 43151.W5JME3; -.
DR EnsemblMetazoa; ADAC002685-RA; ADAC002685-PA; ADAC002685.
DR VEuPathDB; VectorBase:ADAC002685; -.
DR VEuPathDB; VectorBase:ADAR2_008254; -.
DR eggNOG; KOG2284; Eukaryota.
DR HOGENOM; CLU_004747_6_1_1; -.
DR OMA; CQEQMEI; -.
DR OrthoDB; 5474206at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016157; Cullin_CS.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR PANTHER; PTHR11932:SF177; CULLIN-2; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS01256; CULLIN_1; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 408..637
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
SQ SEQUENCE 762 AA; 89082 MW; 922F657649861AF0 CRC64;
MSLKPRNINF DLVWDELRDT VLKVLTLQHV NRTVWSNRFG DVYVLCVAHP EPLADRLYLE
TKLFLENHVF KLLEERVLVD SEIKDDTTSS GPTASADLLL ARYHEVWKEY SEGSKYLNNI
YQYLNNQHIK KQKLNEAEVV YGCINQSDSQ EKMEIGDLAL EIWNQYMIQR LGDELVDQIL
KGINAERTSA NNSQSNSSTN FIKGVIQSFV AVQEYRRKGS LKLYQDLFEK RMLEESAQHF
RMVASELLQV CTVSQYMEKI IKKFEEEEKL ANIYLHASSL PKLRKVCEEE MVTKHMNFLY
SECKEMVAEE RSADLRNLYI LLKPVTDGLK RLIDVFLEHI KEQGKKTIAC MKGDLVHIQF
VENMLDVHRK YEELIHRTFR SDPLFLGALD KACARIINEK HSNNQVCRSA ELVAKYCDSL
LKKSKTTEGE IDQKLTRSII IFKYIEDKDV YQKFYSRMLA KRLIHEQSQS MDAEEMMINK
LKQACGYEFT NKLHRMFTDI SVSTDLNAKF TNYLNENWLE TGINFSVKVL QAGAWPLGPT
QIVASFAIPQ EFEKSIRLFE KFYHINFSGR KLTWLHHLCH GEMKLSFEKR NYIVTMQTYQ
MAILLMFETT DKYTCKELQA SLQLQQEIFQ RHLQSLVEAK ILLLNEEKMT DDTEVSINTN
YNNKRTKFKI TTNLQKETPQ EVEHTMSAVD EDRKMYLQAA IVRIMKSRKV LRHNALIQEI
LSQSKVSFAP NVSMIKKCIE SLIDKQYIER TPNSGDEYSY VA
//
