ID W5JNI8_ANODA Unreviewed; 434 AA.
AC W5JNI8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=3',5'-cyclic-AMP phosphodiesterase {ECO:0000256|ARBA:ARBA00012276};
DE EC=3.1.4.53 {ECO:0000256|ARBA:ARBA00012276};
GN ORFNames=AND_003813 {ECO:0000313|EMBL:ETN64445.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN64445.1};
RN [1] {ECO:0000313|EMBL:ETN64445.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN64445.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN64445.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC003813-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; ADMH02001018; ETN64445.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JNI8; -.
DR STRING; 43151.W5JNI8; -.
DR EnsemblMetazoa; ADAC003813-RA; ADAC003813-PA; ADAC003813.
DR VEuPathDB; VectorBase:ADAC003813; -.
DR VEuPathDB; VectorBase:ADAR2_003962; -.
DR eggNOG; KOG3689; Eukaryota.
DR HOGENOM; CLU_631955_0_0_1; -.
DR OrthoDB; 3136243at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR InterPro; IPR040844; PDE4_UCR.
DR PANTHER; PTHR40141:SF4; -; 1.
DR PANTHER; PTHR40141; 3',5'-CYCLIC-AMP PHOSPHODIESTERASE-RELATED; 1.
DR Pfam; PF18100; PDE4_UCR; 1.
PE 4: Predicted;
KW cAMP {ECO:0000256|ARBA:ARBA00023149};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673}.
FT DOMAIN 331..433
FT /note="Phosphodiesterase 4 upstream conserved regions
FT (UCR)"
FT /evidence="ECO:0000259|Pfam:PF18100"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 434 AA; 44160 MW; 962DEAC78F71DCDC CRC64;
MDQTDSRRRL ATASAEQPPA WPPTVPTFEY RTVRINQHQH QHHQQHHQFY STSTSSTESS
STMLRSGTIQ QQLAGRAPVA AAAAAASALR PPTAPAALLG GVSDVVRQHH QYHQQRFKLF
MDNADGSSSG PASGVMSVAG GFTSRRSPLL LPGSGDGGAG GGPGGPGLLS AALPQRRESF
LYRSDSDFEI SPKVSSVSLM AARCGNAGSG SATASTASTS NAGSAGGGIG LPSLGRDGSF
HSSREGCTLD ESAAAAGWVG QQPSIVSSPS SSATTVVGGQ VGAASTTTIV ATSSSTASTE
RTTMMSGPGG VGGGGTGVGV SSSGHHDDLI VTPFAQILAS LRTVRANLYA LSSAIPSAVA
DRSGDSSATE TAPDSSSASG GAERRPSAEG DVRQLATQTI DELEWCLEQL ETVQTHRSVS
DMASLKVSRS LGRR
//
