ID W5JNN6_ANODA Unreviewed; 602 AA.
AC W5JNN6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=FERM domain-containing protein 8 {ECO:0000256|ARBA:ARBA00039547};
GN ORFNames=AND_002239 {ECO:0000313|EMBL:ETN65987.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN65987.1};
RN [1] {ECO:0000313|EMBL:ETN65987.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN65987.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN65987.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC002239-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; ADMH02000547; ETN65987.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JNN6; -.
DR STRING; 43151.W5JNN6; -.
DR EnsemblMetazoa; ADAC002239-RA; ADAC002239-PA; ADAC002239.
DR VEuPathDB; VectorBase:ADAC002239; -.
DR VEuPathDB; VectorBase:ADAR2_006343; -.
DR eggNOG; KOG4335; Eukaryota.
DR HOGENOM; CLU_467106_0_0_1; -.
DR OMA; YIRREWN; -.
DR OrthoDB; 2879691at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR13283:SF10; FERM DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR13283; KREV INTERACTION TRAPPED 1-RELATED; 1.
DR Pfam; PF00373; FERM_M; 1.
DR SMART; SM00295; B41; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000673}.
FT DOMAIN 196..542
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 66511 MW; 26A24D89A583DBAE CRC64;
MLHVKVDDSP ASSSGSNNNY QLGNGNTGDQ QQQQQQQQSK YTTTTTGNTT SAAATKQQAL
HQQQQQQSSF SKQPTLVQPQ QQQSTSLSGH PAQHPASVSY HPTSGGGPVA GSGLLRPADS
NPFASSTAGA ASQHHLQQQQ QQHYQQPLQP QTGSVNVNVT VNVVARSVTA GTMTTTTATT
TSTTTLAPPR PMQKVIPTVV YLMSRIAVHM EIEGTAQCPA QVMLAAALGC EELGITNKLL
AQSVFGLWMT SPLLEVQLKP HHRPYAVRVA WSKLLDKHSH GNELEKLSDE PMTTLRRNVF
FSRKDEEKIK DPRILELLYE EARHNVLLGR YVMEPSQSIM LGGIQARIEL GPYNSHTHTT
SYFRENQFRF LPAHVAKSSS WSWLPISQRS SAEVRLLEQF KRVPTTATTK KLMRKYLEFC
WGLPFYGAAY FHGQVEQPVR GLMSLMQQKD LPVLIAVNER GIFVIDQIEC TLLLGLKYEE
FSWEYAKPSN VNDPECLPCI FLQFGAVENG IAATKLMQIF SRQAAMVDAL ITHFIEQDKR
RKESGADADQ AGGLADNTYV EPNPIKNNGI GVLSNKFARL TLATFDDEGR CIGQTGSLSI
SY
//
