ID W5JPB7_ANODA Unreviewed; 560 AA.
AC W5JPB7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Lactase-phlorizin hydrolase {ECO:0000313|EMBL:ETN64735.1};
GN ORFNames=AND_003514 {ECO:0000313|EMBL:ETN64735.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN64735.1};
RN [1] {ECO:0000313|EMBL:ETN64735.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN64735.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN64735.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC003514-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 1 family.
CC {ECO:0000256|RuleBase:RU003690}.
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DR EMBL; ADMH02000892; ETN64735.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JPB7; -.
DR STRING; 43151.W5JPB7; -.
DR EnsemblMetazoa; ADAC003514-RA; ADAC003514-PA; ADAC003514.
DR VEuPathDB; VectorBase:ADAC003514; -.
DR VEuPathDB; VectorBase:ADAR2_004331; -.
DR eggNOG; KOG0626; Eukaryota.
DR HOGENOM; CLU_001859_1_3_1; -.
DR OMA; NWETLRC; -.
DR OrthoDB; 3373839at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR001360; Glyco_hydro_1.
DR InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR PANTHER; PTHR10353:SF36; KLOTHO (MAMMALIAN AGING-ASSOCIATED PROTEIN) HOMOLOG; 1.
DR Pfam; PF00232; Glyco_hydro_1; 1.
DR PRINTS; PR00131; GLHYDRLASE1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ETN64735.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..560
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010155709"
FT REGION 504..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..523
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 63544 MW; 7A71EC0D392E7BCC CRC64;
MKHSVALLVF ACLGTRWLVA GQRKFPEHFK FGVGTSAYQI EGGWNEDGKG ESIWDYLVHN
NPEKVADGTN GDIACDSYHQ WRRDVEMIKE LGVDIYRFSL SWSRILPTGI SNEINPKGIE
YYNNLIDELL SKGITPMVTL FHWDTPQRLQ ELGGFTNRLI VGYFREYARV AFEHFGDRVK
IWTTFNEPPQ TCRLPYEYGS FAPGQAFPGI YTYLCSHHLL LSHAEAVELY RTEFQPTQGG
QIGITVDGSW AEPVSEAERE ASDLTMQYLF GIYMHPIYSE TGNYPPVIIE RIAKLSQEQG
FAKSRLPEFT PEEIAKLKGS SDFFGYNGYT TNLVYMNDEA NSANFREPSF DHDRNTVDYQ
DDRWPSTGSS WLKVNPRGMY NVLNWIRREY NNPPVWVTEN GVSDRGGTRD VQRVQYFKDY
LNAILDAIDD GCDVRGYVAW SLMDNFEWLA GLTERFGLYY VDYTDPARTR YAKSSARAFG
NIVRNRMIDP NDMPEPEIYI PGPGETPATT TIHPTTTVRA TTTNTDDDDG DDDGSATGLM
ISKILLAAGI GVTVLLIADY
//
