ID W5JTM1_ANODA Unreviewed; 270 AA.
AC W5JTM1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Defective in cullin neddylation protein {ECO:0000256|RuleBase:RU410713};
GN ORFNames=AND_000721 {ECO:0000313|EMBL:ETN67471.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN67471.1};
RN [1] {ECO:0000313|EMBL:ETN67471.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN67471.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN67471.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC000721-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Neddylation of cullins play an essential role in the
CC regulation of SCF-type complexes activity.
CC {ECO:0000256|RuleBase:RU410713}.
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DR EMBL; ADMH02000180; ETN67471.1; -; Genomic_DNA.
DR AlphaFoldDB; W5JTM1; -.
DR STRING; 43151.W5JTM1; -.
DR EnsemblMetazoa; ADAC000721-RA; ADAC000721-PA; ADAC000721.
DR VEuPathDB; VectorBase:ADAC000721; -.
DR VEuPathDB; VectorBase:ADAR2_002578; -.
DR eggNOG; KOG3077; Eukaryota.
DR HOGENOM; CLU_047042_0_1_1; -.
DR OMA; EKTAVNC; -.
DR OrthoDB; 169757at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR Gene3D; 1.10.238.200; Cullin, PONY binding domain; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR014764; DCN-prot.
DR InterPro; IPR042460; DCN1-like_PONY.
DR InterPro; IPR005176; PONY_dom.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR12281:SF32; DCN1-LIKE PROTEIN; 1.
DR PANTHER; PTHR12281; RP42 RELATED; 1.
DR Pfam; PF03556; Cullin_binding; 1.
DR Pfam; PF14555; UBA_4; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS51229; DCUN1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 55..243
FT /note="DCUN1"
FT /evidence="ECO:0000259|PROSITE:PS51229"
SQ SEQUENCE 270 AA; 31917 MW; 3B08681937FF93E0 CRC64;
MNKLKLNQKD KVKKFISLTH TGEQTAIRCL QENDWKLDIS CDNYFQNPDL YYRELDRKKI
EQLFNVYRDP ADPNKINSDG VERFLEDLHL SPESKLVLII AWRFKAEAQC EFSRLEFLNG
FYDLGVDSLE KLKEKLPRLE HELKDPGRFK DFYQFTFNYA KDPGQKGLDL DMAIAYWNIV
LKDRFKFLDL WCKFLVENHK RSIPKDTWNL LLDFATYIDD SMSNYDAEGA WPVLIDDFVE
WCLKQNKSLF SARNIILVLL LHCAVGLASF
//
