ID W5JWC0_ANODA Unreviewed; 1827 AA.
AC W5JWC0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Brefeldin a-inhibited guanine nucleotide-exchange protein {ECO:0000313|EMBL:ETN67279.1};
GN ORFNames=AND_000914 {ECO:0000313|EMBL:ETN67279.1};
OS Anopheles darlingi (Mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=43151 {ECO:0000313|EMBL:ETN67279.1};
RN [1] {ECO:0000313|EMBL:ETN67279.1, ECO:0000313|Proteomes:UP000000673}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20920257; DOI=10.1186/1471-2164-11-529;
RA Mendes N.D., Freitas A.T., Vasconcelos A.T., Sagot M.F.;
RT "Combination of measures distinguishes pre-miRNAs from other stem-loops in
RT the genome of the newly sequenced Anopheles darlingi.";
RL BMC Genomics 11:529-529(2010).
RN [2] {ECO:0000313|EMBL:ETN67279.1}
RP NUCLEOTIDE SEQUENCE.
RA Almeida L.G., Nicolas M.F., Souza R.C., Vasconcelos A.T.R.;
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ETN67279.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23761445;
RA Marinotti O., Cerqueira G.C., de Almeida L.G., Ferro M.I., Loreto E.L.,
RA Zaha A., Teixeira S.M., Wespiser A.R., Almeida E Silva A.,
RA Schlindwein A.D., Pacheco A.C., Silva A.L., Graveley B.R., Walenz B.P.,
RA Lima Bde A., Ribeiro C.A., Nunes-Silva C.G., de Carvalho C.R., Soares C.M.,
RA de Menezes C.B., Matiolli C., Caffrey D., Araujo D.A., de Oliveira D.M.,
RA Golenbock D., Grisard E.C., Fantinatti-Garboggini F., de Carvalho F.M.,
RA Barcellos F.G., Prosdocimi F., May G., Azevedo Junior G.M., Guimaraes G.M.,
RA Goldman G.H., Padilha I.Q., Batista Jda S., Ferro J.A., Ribeiro J.M.,
RA Fietto J.L., Dabbas K.M., Cerdeira L., Agnez-Lima L.F., Brocchi M.,
RA de Carvalho M.O., Teixeira Mde M., Diniz Maia Mde M., Goldman M.H.,
RA Cruz Schneider M.P., Felipe M.S., Hungria M., Nicolas M.F., Pereira M.,
RA Montes M.A., Cantao M.E., Vincentz M., Rafael M.S., Silverman N.,
RA Stoco P.H., Souza R.C., Vicentini R., Gazzinelli R.T., Neves Rde O.,
RA Silva R., Astolfi-Filho S., Maciel T.E., Urmenyi T.P., Tadei W.P.,
RA Camargo E.P., de Vasconcelos A.T.;
RT "The genome of Anopheles darlingi, the main neotropical malaria vector.";
RL Nucleic Acids Res. 41:7387-7400(2013).
RN [4] {ECO:0000313|EnsemblMetazoa:ADAC000914-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; ADMH02000239; ETN67279.1; -; Genomic_DNA.
DR STRING; 43151.W5JWC0; -.
DR EnsemblMetazoa; ADAC000914-RA; ADAC000914-PA; ADAC000914.
DR VEuPathDB; VectorBase:ADAC000914; -.
DR VEuPathDB; VectorBase:ADAR2_011614; -.
DR eggNOG; KOG0929; Eukaryota.
DR HOGENOM; CLU_000691_1_2_1; -.
DR OMA; MENQVYE; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000000673; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF375; LD29171P; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000000673};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 671..860
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1497..1546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1827 AA; 203027 MW; 97B1C2A6833BC79F CRC64;
MQSAATTVAS SNTNAKKTTS SVGGTSGSGA HTKTKEMFIL RALEKILSDK DIKRSHHLQL
KRACDVALED IKEELKQAGH TEPNGEAPVP SAALPLPKND SGNIINAEKY FLPFELACQS
RTPRIVVTAL DCLQKLIAYG HLTGNIPDSS NPGKFLIDRI VTTICNCFMG PQTDEGVQLQ
IIKALLTVVT SQHVEVHEGT VLQGVRTCYD IYLSSKNLIN QTTARATLTQ MLNVIFTRME
NQAFETVVTA ATVVSPVSPT TPSSSSAIAN AVEDSPSSVP DVALAEEKSP DYDEIRAIVE
EIVDNVIAQA QVQAGVSNGA TGEPMVNNEA SETASIGGVS IGGTTDTTSI ARVPSQESME
VTSENDSIVT AKFTHILQKD AFLVFRALCK LSMKPLPEGH PDPKSHELRS KILSLHLLLS
ILQNAGPVFR SNEMFIMAIK QYLCVALSKN GGSAVPEVFE LSLSIFVALL SNFKTHLKKQ
IEVFFKEIFL NILEAPSSSF EHKWMVIQAL TRICADAQSV VDIYVNYDCD FSAANLFERL
VNDLSKIGQG RQALELGTSV NQEKSMRIRG LECLVSILKC MVEWSKDLYV NPNSQTSLGD
PPTTVTTSKS VSSGALDEIQ QDTSGSSRLE LKSHGGSSVS INSVGSNNTS GAGANGSGNG
GNQEVLDLPG ELEERKHRKE VMETGIEMFN RKPKKGIAFL QERGLLGTSV EDVAQWLHED
ERLDKTQIGD YLGENEERSK AVMCAYIDAM NFADLDIVAA LRHFLEGFRL PGEAQKIDRL
MEKFASRYCD CNPNNTLFAS ADTVYVLAFS VIMLTTDLHS PQVKHKMTKE QYIRMNRGIS
DNKDLPEEYL SQIYDEIAGH EIKMKNTVAN KPSGKQLIAN EKKRKLLWNL EMESLSTTAK
NLMESVSHVK ASFTSAKHLE HVRPMFKMAW TSFLAAFSVG LQDCDDPEIA SLCLDGIRCA
VRIACIFHMS LERDAYVQAL ARFTLLTANS PINEMKAKNI DTIKTLIMVA HTDGNYLGSS
WLDIVKCISH LELAQLIGTG VRPEFLSGPA SHRDTLDPSA KEHIGETSSQ SIVVAVDRIF
TGSIRLDGDA IVDFVKALCQ VSLDELNRPQ PRMFSLQKIV EISYYNMGRI RLQWSRIWQI
LGEHFNAVGC NTNEEIAFFA LDSLRQLSMK FIEKGEFTNF RFQKDFLRPF EHIMKKNNSP
AIRDMVVRCV AQMVNSQAHN IKSGWKNIFS VFHLAAGDHD EAIVELAFLT TGKIITELYQ
TQFPIMIDSF QDAVKCLSEF ACNARFPDTS MEAIRLVRTC ALCVNDAPNL FAEHAGMEND
VSVPEEDRVW VRGWFPMLFS LSCVVNRCKL DVRTRGLTVL FEIVKTHGDA YRANWWRDLF
NVLFRIFDNM KLPEHQTEKA EWMTTTCNHA LYAIIDVFTQ YFDVLGPMLL ADLYCQLHWC
VQQNNEQLAR SGTNCLENLV ISNGLKFSED TWGKTCQCML DIFNSTLPKE LLTWKPDPLP
QTTPTTATAA KHENGDLPRH GILKRSSSQH SMHADHHLGA TNDPNLSTGT AVSPSTTVLF
SNLLIKCVVQ LELIQTIDNI VFFPATSRKE DAETLAQATA ELTSSSVPTS NGQLHHATTS
YHHSLSLSSS ELECQREEQG MYSYLNTPHL LQLVDCLLQS HRFAKKFNSN NDQRTVLWKA
GFKGFLKPNL LKQETQSLAC VLRILFKMYC DENRRRDWQD IEQRLIGVCT EALDYFLSLD
SGPHRDAWTS LLLLVMTRLL KMPDARFAAH IASYYVFLCD LTCVDLKPEL RTVLRRVFLR
ISPVFGISTA TSQGTGGSNS SGTLAAT
//
