ID W5JYV6_ASTMX Unreviewed; 1502 AA.
AC W5JYV6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Nuclear receptor coactivator {ECO:0000256|PIRNR:PIRNR038181};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000000516.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000000516.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR038181}.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933, ECO:0000256|PIRNR:PIRNR038181}.
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DR STRING; 7994.ENSAMXP00000000516; -.
DR Ensembl; ENSAMXT00000000516.2; ENSAMXP00000000516.2; ENSAMXG00000000511.2.
DR Ensembl; ENSAMXT00000057160.1; ENSAMXP00000029492.1; ENSAMXG00000000511.2.
DR eggNOG; KOG3561; Eukaryota.
DR GeneTree; ENSGT00950000183021; -.
DR HOGENOM; CLU_001988_0_0_1; -.
DR OrthoDB; 4230728at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000000511; Expressed in camera-type eye and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18950; bHLH-PAS_NCoA2_SRC2; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 6.10.140.20; Nuclear receptor coactivator, Ncoa-type, interlocking domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR032565; NCOA2/3_DUF4927.
DR InterPro; IPR028822; NCOA2_bHLH.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF2; NUCLEAR RECEPTOR COACTIVATOR 2; 1.
DR Pfam; PF07469; DUF1518; 2.
DR Pfam; PF16279; DUF4927; 1.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 1.
DR SMART; SM01151; DUF1518; 2.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|PIRNR:PIRNR038181};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR038181};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR038181};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR038181}.
FT DOMAIN 27..84
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 120..184
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1238..1328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1367..1401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1471..1502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1280..1305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1306..1323
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1502 AA; 161846 MW; 09ECA1F65AC16FC3 CRC64;
MSGVGDNTSD PVRVESQKRK ECSSDLLGPS PKRSTEKRNR EHENKYIEEL AELIFANFND
IDNFNVKPDK CAILKETVKQ IRQIKEQEKA AAANEEEVQK ADVSSTGQSV IDKDALGPMM
LEALDGFFFV VNMEGNIVFV SENVSQYLRY NQEELMNTSV YSILHVGDHA EFIKNLLPKS
LVNGVPWSSE NPRRNSHTFN CRMLVNPHSE PEEEAQEQEA QQKYETMQCF AVSEPKSIRE
EGEDLQSCLI CVARRVPMKE RPMLPTHESF TTRQDLQGKI TSLDTSLLRA SMKPGWEDLV
RRCIQRFHLQ NDGDMSYAKR HQQEVLRHGQ AFSPVYRFSL SDGTIVSAHT RSKLVRSPAT
NEPQLYMSLH ILQREQTVCG MTPDMATGQP MGKPMNPMAS MTSPNSAGSS QGQDSTISSN
TSTFPSPGAP KDSTAVGPVQ GYRFGCPGTM GHAAPMQGAT PQGSGYSLKM NSPSQGSPGM
LSPRHRASPG IAGSPRMPPP QFSPANALHS PVPVCNSSGN VGGAHGYTSS SLNALQALSE
CHNISLGPAL GSPDRKLASP ANPAGVNPHL LHKLGGSESY AEHSQVEHDG NVQGDGSEEQ
RDDKGNPDSG DLQNRLPDNK GHTKLLQLLT TKTEPIESTS PPLLGGELGC KDQSGGPGGQ
TGASGSHATS LKEKHKILHR LLQNSTSPVD LAKLTAEATG KEMCQDGSGG GANVPDLVPK
QEPVSPKKKD NALLRYLLDK DDNMMKDKGV KMEPGEIKTE GVKMGGVKVE KPDTGYERTE
QSSELDDILD DLHNAQPGLF SESRPVSLPA AVDKQSIIND ILQITGEGGA TQQQRVMHVM
AQQNFSGPRH PGRTPGQSIS LEMNMAAKAS PGQYPLMRNT SPYSLMQQQQ QQGMLGNKGV
MHNQPNMPVM SGAGGRAGLQ QDVWVSQGSG VVSSSPSSAV PPTQPLQQGA LQARMAQNAN
PNMGMRASGQ PGPRAMLQGQ MMSNAQSNMD MDMSLTGPPF PQQQQQAPPN QTAPWPDSMM
PIESLPLPFG NPSRPVYSAP QEDVLCPPEG PADEGTLLNQ LYTALKDFDG LEEIDRALGI
PALVGQGGPV ESDQFSGQDP SMMMDQKPPM FTQQQYGPPQ PHMGQGGYPP LQDPSGYHNM
AGPMGQRPGF PMIRMPSRPG LRPTAVIPNQ PNALRLQLQH RLQAQQNRQP MMNQMSGVSN
MNLPLRPNVP NQGTINAQML AQRQRELLSN HLRQRQLDQQ RLQHHQQQQQ QRSMAMRTPG
LNMPPNLPAG TGGLPGAMSN PRIPQTSGQQ FPYTPNYGTG LASPPPSTSP FSPASPNLPA
PQLLPHAPLH GSQMTLANQG ILGSVGGQFG PVMSPQMQHS AFQFPSPGMS QQPDGGFGGA
TTPQSPLMSP RMGHAQSPMM QQAPGNATFQ SSPDMNGWTQ GNVNANSMFP QQSPPQFGQQ
SNGGVYNGSG MNLNVSMAPN SSSMNNMAPN SSSMNSMGQM GGQMTSGPAG GMANMGPEQK
YC
//
