ID W5JZ34_ASTMX Unreviewed; 449 AA.
AC W5JZ34;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=CTD small phosphatase-like protein 2-A {ECO:0000313|Ensembl:ENSAMXP00000000594.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000000594.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000000594.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Probable phosphatase. {ECO:0000256|ARBA:ARBA00037324}.
CC -!- SIMILARITY: Belongs to the CTDSPL2 family.
CC {ECO:0000256|ARBA:ARBA00038355}.
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DR AlphaFoldDB; W5JZ34; -.
DR Ensembl; ENSAMXT00000000594.2; ENSAMXP00000000594.2; ENSAMXG00000000583.2.
DR eggNOG; KOG1605; Eukaryota.
DR GeneTree; ENSGT01040000240503; -.
DR HOGENOM; CLU_034042_4_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000000583; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0016791; F:phosphatase activity; IEA:InterPro.
DR CDD; cd07521; HAD_FCP1-like; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR011948; Dullard_phosphatase.
DR InterPro; IPR004274; FCP1_dom.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR NCBIfam; TIGR02251; HIF-SF_euk; 1.
DR PANTHER; PTHR12210:SF173; CTD SMALL PHOSPHATASE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR12210; DULLARD PROTEIN PHOSPHATASE; 1.
DR Pfam; PF03031; NIF; 1.
DR SMART; SM00577; CPDc; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR PROSITE; PS50969; FCP1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 287..425
FT /note="FCP1 homology"
FT /evidence="ECO:0000259|PROSITE:PS50969"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..38
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 449 AA; 50555 MW; 1F264DFFCBAA82CF CRC64;
MRLRVRKASQ QPSPTQPART TKAKRKHSEV EHTRPSGGAR MQKSDTGIFS TIKRFIRGNA
VKVEQCTPAK RSRVDCDSDS NLITSTPPTG NLPSRTNPRT RRKGPANGDT MACESKLVKP
NGKLEVQTDT PSSPPRTTLL GTIFSPVFNF FSPANKNATL GSDSPGQAVE AEEIVKQLDM
EQLEETPTST TTDGSRDITF DPALNSRPLL PTDTTVEEGE IATETDMPPL TAVGSNSNYP
DAPPSPPAEG TYEEDWEVFD PYFFIKHVPP LTEEQLTRKP ALPLKTRSTP EFSLVLDLVN
LLVDFSVYVR LRPFFREFLE RMSQIYEIIL FTASKKVYAD KLLNILDPKK QLVRHRLFRE
HCVCVQGNYI KDLNILGRDL SKTIIIDNSP QAFAYQLSNG IPIESWFVDK NDNELLKLVP
FLENLVELNE DVRPHIREKF RLHDLLPPD
//
