ID   W5JZB0_ASTMX            Unreviewed;       721 AA.
AC   W5JZB0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000000670.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000000670.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the OSBP family.
CC       {ECO:0000256|RuleBase:RU003844}.
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DR   AlphaFoldDB; W5JZB0; -.
DR   STRING; 7994.ENSAMXP00000000670; -.
DR   Ensembl; ENSAMXT00000000670.2; ENSAMXP00000000670.2; ENSAMXG00000000651.2.
DR   eggNOG; KOG1737; Eukaryota.
DR   GeneTree; ENSGT00940000155957; -.
DR   HOGENOM; CLU_007105_4_1_1; -.
DR   InParanoid; W5JZB0; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000000651; Expressed in intestine and 14 other cell types or tissues.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.160.120; -; 1.
DR   Gene3D; 3.30.70.3490; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR10972:SF15; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS01013; OSBP; 1.
PE   3: Inferred from homology;
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW   ECO:0000256|RuleBase:RU003845};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Transport {ECO:0000256|RuleBase:RU003845}.
FT   REGION          156..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   721 AA;  82399 MW;  1A04F67B38AE7CE0 CRC64;
     FVFWQRYFLL EKGILMYAKT LADLKKGKLR GRIDVGLSVM SIKKKAMCID LDTEDSIYHL
     KVKTRDLFDG WVSQLRNHRV FRQNEIAMDP HERQLHPDSA SLRRVIIASA SHGAPTVQPQ
     IRKNLSECEM SLLELNLLLK NMEVLHRTFS APSINTLQTE GSKKEKKGRR WRSRNHSKNG
     KNNLQASGSK SSRLHVSNPN LTYSEPNSPR PETQTHLETP DSPIHASRLQ EEFCRLASNV
     HATLKSAYSS LCSERDRVRN TLDLRNDVMD GHRPLLQQAS NGSRSSIPDS LSEFFDANEY
     LLSASSSENE LSDNDSCVSD VSDNVSVDFC PSETGAEREN SVMPRRSRLP SACVSEGVNL
     WSILYSNIGK DLSKVSMPIQ LNEPISTLQR LCEEMEYCHL LDTAAHTHDP DMRMVYVAAF
     AVSAYACSYT RAGMKPFNPI LGETYECERP DKGFRFISEQ VSHHPPVSAC HCESKNFTLW
     QDVRWKNKFW GKTMEIVPMG TTHIVLPRFG DHYELNRVTS CIHNILSGQR WIEHYGEMTI
     RNTAAAENAG HCKVTFYKAS SRGLKVNKVE AVVTDAEGRV VHSLFGKWNE ALFLGEPPSA
     LCVWRANPMP EDHEQFYGFT QFAIELNELD ENIKPFLPPT DTRFRPDQRL LEEGNVSAAE
     EQKERIEALQ RERRRVLQEN NMSHAPRFFK RSEDDAWLSN GTYWELRKDP GFSKLDFPLL
     W
//