ID W5JZY1_ASTMX Unreviewed; 373 AA.
AC W5JZY1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=L-threonine 3-dehydrogenase, mitochondrial-like {ECO:0000313|Ensembl:ENSAMXP00000000891.1};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000000891.1, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000000891.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007252097.1; XM_007252035.2.
DR AlphaFoldDB; W5JZY1; -.
DR STRING; 7994.ENSAMXP00000000891; -.
DR Ensembl; ENSAMXT00000000891.2; ENSAMXP00000000891.1; ENSAMXG00000000872.2.
DR GeneID; 103040243; -.
DR KEGG; amex:103040243; -.
DR eggNOG; KOG2774; Eukaryota.
DR GeneTree; ENSGT00390000014037; -.
DR HOGENOM; CLU_007383_19_1_1; -.
DR InParanoid; W5JZY1; -.
DR OMA; SSWPAKF; -.
DR OrthoDB; 177053at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000000872; Expressed in camera-type eye and 13 other cell types or tissues.
DR CDD; cd05272; TDH_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42687; L-THREONINE 3-DEHYDROGENASE; 1.
DR PANTHER; PTHR42687:SF4; L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 58..293
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 373 AA; 41576 MW; CBF528C73D608BD6 CRC64;
MPVVRTVSKV VQQVLLAPAC SCGPLSLSVR SISFSPRQVT SDASFHSVSF SETDHPRVLI
TGGLGQLGVG LAKLLRKRFG KNNVILSDIR KPPDHVFRSG PFIYSDILDY KNLREIVVNN
RITWLVHYSA LLSAVGEANV TLARNVNITG LHNILDISAE HGLRLFVPST IGAFGPTSPR
NPTPDLCIQR PRTIYGVSKV HAELMGEYYH HRNGLDFRCL RYPGIISADS QPGGGTTDYA
VQIFHDAVKT GKFVCNLKPD TRLPMMFIDD CLRATLEVME APAEALSMRT YNINAMSFTP
EELAREVQKQ LPDLQVTYEI DPVRQAIADS WPMSFEDSNA RKDWGWKHEY DLPELIQTML
NFIGSDSRIA HAN
//
