ID W5K060_ASTMX Unreviewed; 1368 AA.
AC W5K060;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRZ1 {ECO:0000313|Ensembl:ENSAMXP00000000970.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000000970.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000000970.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 5 subfamily. {ECO:0000256|ARBA:ARBA00006246}.
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DR STRING; 7994.ENSAMXP00000000970; -.
DR Ensembl; ENSAMXT00000000970.2; ENSAMXP00000000970.2; ENSAMXG00000000934.2.
DR eggNOG; KOG0789; Eukaryota.
DR GeneTree; ENSGT00940000155529; -.
DR HOGENOM; CLU_001120_2_0_1; -.
DR InParanoid; W5K060; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000000934; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd03122; alpha_CARP_receptor_like; 1.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR041887; Alpha_CARP_receptor-type.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF461; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ZETA; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1368
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017279057"
FT DOMAIN 39..302
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
FT DOMAIN 316..413
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 766..1042
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 959..1033
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1073..1334
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1251..1325
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 438..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1343..1368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1368 AA; 152683 MW; BC0BCCF41114BC69 CRC64;
MESLDSKCAL SLALLLICQI VEVSQAYGFR SQKKLAENID WSYAGTLNQN NWAKKYPSCN
NAKQSPINIE ESLSQVKVQY QKLRLEHWDQ DTSDFTTVKN DGKTVAIDVG GEFFISGGGL
RSRFKVGRLT FHWGRCNASS DGSEHSLNGV KFPLEMQIYC HEDNHSSVDA AIRDGGRITA
LSVFIETSVE DNENYAAIID AVNSVSRHGK TGSVSPFTLQ GLLPNSTEKY FIYNGSLTSP
PCSETVEWIV FKNTAAISEA QLEMFCEVMT MQQAGYVMLM DYLQNNYREQ QSQFMGQVFS
SYTGTEELLT PVCSTEPENV QAYPHNYTSL LVIWERPRAV YDASIEKYSV TYRQIQGEDP
PTLEYLTDGD QDVGAIIQDL AANTSYMVQV VAVCTNGLNG RTSEQLIVDM PVNDPETDPD
PDPFELDEEE SYQPNPFLVR HDLNQPPYPV RTTTPRPRFT TTDPPVPPIF GVTSRATTTT
IATTTTIATT TATTTAISTT TSTEIQVQYT PQTAQTTTIT TLMTDLLAPE SDYSGSSEPT
DLLTSESHYS SSTTLIMATE GDSSSHTFVE PTVETVTPDA ESSSTSAVAG GEEVIDSIDN
SGDSTVSVTT VTTVSPLSEN FATSTSSLPP PEVPLQPTTP SVPFPTTTAF SAVLLQTTQP
VFKDASNSSH ESRVSLVGSV ERQRKAVVPL AVVSTLTFLC LVILIGILIY WRKCFQTAHF
YIEDSTSPRV ISTSPAHLLL RTDEHEPLSV KQFVKHVAEL HNNNSFSREF QILKECFEEV
QACTVDLGTT TDSSNHPENK TKNRYVNILA YDHSRVRLSA QSDKDGKNEG DYINANFVDG
FNQQRAYIAA QGPLKSSTVD FWRMVWEQNV GVIVMITNLV ENGRRKCDQY WPLETQEEYG
CFLVTVKSTE VMAYYTQRTF TIRNTHVKKG SQKGRANERT VTHYHYTQWP DMGVPEYVLP
VISFIRRSSR ARTQDMGPVV VHCSAGVGRT GTYIVLDSMM KQISEQGLVN ILGFLKHIRT
QRNYLVQTEE QYVFIHDALV EAILSKETEV PTSRVHNYVN ELLTTGPSCR TRLEKQFKLV
NQSSAKQCDY SSALKDCNRE KNRSSSLIPV ERSRICLSTS ADETTDYINA SYILGYRKSS
EYIITQNPLP ATVKDFWRMI WDHNAQVIVS LPDTSSLTEE PEPMIFWPKR DQPISCSMFT
VSLGREERVC MSNEEMLIVQ DYILEATKDD YVLEVRHYRA PRWPNPDAPI SNTFELINII
QRERSLKEGP IVVHDDYGGV TAGTFCALHT LLQQLETDSS VDVYLVAKMI NLMRPGVFTD
IEQYQFLYKA ILSLVGTQED EKALQSSDNN GAVPGGPASA TESLESLV
//
