ID W5K110_ASTMX Unreviewed; 417 AA.
AC W5K110;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Saccharopine dehydrogenase-like oxidoreductase {ECO:0000256|ARBA:ARBA00039852};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000001270.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000001270.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the saccharopine dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00038048}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; W5K110; -.
DR STRING; 7994.ENSAMXP00000001270; -.
DR Ensembl; ENSAMXT00000001270.2; ENSAMXP00000001270.2; ENSAMXG00000001247.2.
DR eggNOG; KOG2733; Eukaryota.
DR GeneTree; ENSGT00390000004799; -.
DR HOGENOM; CLU_031002_1_0_1; -.
DR InParanoid; W5K110; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000001247; Expressed in intestine and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR12286:SF5; SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE; 1.
DR PANTHER; PTHR12286; UNCHARACTERIZED; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 289..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..149
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
SQ SEQUENCE 417 AA; 45361 MW; E0FC679D9474E8A6 CRC64;
MAEVGSPRRY HFVVFGASGF TGRYVLEEAA RCAAEAREEL RWAAAGRSRA RLETAISQAA
ESLGKPELKT EVDIIVADVD DAESLAVMCK QAVIVLNCVG PYRFFGEPVV KACVENGAHC
VDVSGEPQFL EGMQLKYDGE AGEKGVYIVG SCGFDSIPAD LGILFTRDQF KGTLTSVESF
LTASAGPEGA CIHEGTWQSL VYGLSDSGTL RSLRKKFGHK PLPVVGAKIK RRSALFYSNE
IQQYSVPFMG ADPAVVKRTQ RFLHEELQEN PVQYGAYVGV GGVSSVVKLL FAGLMFWILV
KSVNLFTLTL FTLYTHRTGF FYIMEGSSFR FGFYGEGYTE GQDPSEGKPN AKIRTLVQGP
EAAYVATPIA MVQAAFTILN ELDSLPKKGG VYTPGAAFAK TTLIDRLNKH GIQFSVL
//
