ID W5K2F3_ASTMX Unreviewed; 841 AA.
AC W5K2F3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=GEN1 Holliday junction 5' flap endonuclease {ECO:0000313|Ensembl:ENSAMXP00000001764.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000001764.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000001764.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5K2F3; -.
DR STRING; 7994.ENSAMXP00000001764; -.
DR Ensembl; ENSAMXT00000001764.2; ENSAMXP00000001764.2; ENSAMXG00000001704.2.
DR eggNOG; KOG2519; Eukaryota.
DR GeneTree; ENSGT00940000159266; -.
DR HOGENOM; CLU_013777_0_1_1; -.
DR InParanoid; W5K2F3; -.
DR OrthoDB; 26655at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000001704; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0004520; F:DNA endonuclease activity; IEA:UniProt.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd09869; PIN_GEN1; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR041012; GEN_chromo.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11081:SF73; FLAP ENDONUCLEASE GEN HOMOLOG 1; 1.
DR Pfam; PF18704; Chromo_2; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 1..96
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 128..199
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 469..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 755..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..770
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 841 AA; 93659 MW; 8B5673DAD41692BB CRC64;
MGVNELWSIL NPVRESVPLY SLTGRTLAVD LSLWICEAQH VQAMMGRVTK PHLRNLFFRV
SSLLRMGVKL VFVMEGEAPK IKAETISKRT EGAFRRGKTE SGPKQAKTTN TGRGRFKAVL
RECAEMLDCL GVPWVAAAGE AEAMCAFLDA QGLVDGCITS DGDAFLYGAQ TVYRNFNMNT
KDPQIDCYKM SRVETELQLK RETLVGLAVL LGCDYIPKGV AGVGKEQTLK LIQNLNGQTL
LQKFSEWKSN VIETVEVAAK KVSHCLVCRH PGSAKSHERN GCMYCGSKQF CQPHDYDFQC
PCDWHRTEHA RQSSSIEANI KKKTLACERF PFTEIISEFL VPKDKAVNSF KRKKPNLPLM
QKFALDKMEW PKHYTSEKVL AMMTYTELMN RIHGSETSVQ IKPIRIHKRR IRNGISCFEV
LWTKPDHYVF PGDSPSEKPD DVRTVEEENL FSAAFPHIAQ LFYREAAEAK DNKSKRKKTK
AEKEKPSNSP GVVADLFALM SLQSSTKTEP SSSVETVSSS IMTPKFTSDQ CSTTLDAPKP
PSPCPSGTYS QAQISPSISV VLDELHLSSI DWDAFSFSAS PSSQVQCCVA KTADLSIARK
SEEEEPAVIK KNKEKCVGSV DAQQCSIKIM KKKPDLAHTF GPACKVQSKN QNHFLHSQGQ
QGPTIQQSKG KELGKASFSK ETKLQEPKCH PPQQVRVKST FVTAKQSITS LVSPQRHHVF
LNCSRQSNDL GQPLQQSLCK RSVCINHVSS SEQTDSDIEK CSEKEQKKSK LKSKAKSKPQ
IAHKTVLAPH ATKLNMISTL SKKEKLNHGQ TNQSSDSDDD SGSFTDSPLP LSERLKLTFI
K
//
