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Database: UniProt
Entry: W5K2T8_ASTMX
LinkDB: W5K2T8_ASTMX
Original site: W5K2T8_ASTMX 
ID   W5K2T8_ASTMX            Unreviewed;      1518 AA.
AC   W5K2T8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   16-OCT-2019, entry version 40.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSAMXP00000001899};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000001899, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000001899, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000001899};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000001899}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000001899};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D.,
RA   O'Quin K.E., Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C.,
RA   Volff J.N., Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000001899}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   STRING; 7994.ENSAMXP00000001899; -.
DR   Ensembl; ENSAMXT00000001899; ENSAMXP00000001899; ENSAMXG00000001865.
DR   GeneTree; ENSGT00940000154553; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.10.440; -; 2.
DR   Gene3D; 1.10.555.10; -; 1.
DR   InterPro; IPR002713; FF_domain.
DR   InterPro; IPR036517; FF_domain_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039007; pG1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR032835; RhoGAP-FF1.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR039006; RhoGAP_pG2.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF01846; FF; 1.
DR   Pfam; PF00071; Ras; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF16512; RhoGAP-FF1; 1.
DR   SMART; SM00441; FF; 4.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51676; FF; 3.
DR   PROSITE; PS51852; PG1; 1.
DR   PROSITE; PS51853; PG2; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN      269    326       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      428    482       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      484    549       FF. {ECO:0000259|PROSITE:PS51676}.
FT   DOMAIN      591    771       PG1 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51852}.
FT   DOMAIN      799    969       PG2 pseudoGTPase. {ECO:0000259|PROSITE:
FT                                PS51853}.
FT   DOMAIN     1265   1452       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   REGION      771    791       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1102   1128       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1141   1169       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1229   1255       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1476   1518       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1141   1158       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1237   1251       Basic. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1518 AA;  171958 MW;  28948993F40F5550 CRC64;
     MMAKKQDSRA PTYNLVVVGL SGTEKEKGQC GVGKSCLCNR FVRPSADDFH LDHTSVLSTS
     DFGGRVVNND HFLFWGEVER SLEDGSECRM HVVEQTEFID DQTFQPHRST ALQPYIKRAA
     STKLASAEKL MYFCTDQLGL EQDFEQKQMP EGKLQVDGFL LCVDVSRGMN RSFDDQMKFV
     TNLYNHLGKT KKPVVLVLTK CDEGVERYIK DSHTFAITKK NLQVVETSAR SNVNVDLAFL
     TLMQLIDKGR GKLKIIPYFE ALKHQSQLIA SAKDRYEWLV NHIVKNHNET WPNISRRMQP
     SPEYKEYVFL EGTAKAKKLF QQHIHRLKQE HIERRRKGYL STLPLALSSL VSELDEIEHL
     SWSGVQKVLE SKKDFDHWFV VLEDAPWEDT PHLDNMEDER IPFDVLDTTA AEIIFDAHLE
     HLRNESKRAE MRHEFKMKLA SSPFVTPGKP WEEARSFIMN EDFYQWLEEP EYLDIYNRHQ
     KVIIDRAKED FQELLLEYSE LFYELEVDAK PSKEKMGAIQ EVLGEELRFK ALQKLQAERD
     ALVLKHIHFV YHPTKDTCPS CPYCVDNKIE QTLALCFPTR YPSFGKSHMN DSKADRINLV
     ILGKDGLARE LANEIRALCT NDDHYVLEGK LYELILRPIE GNVRLPVNSF HTATFTPHGC
     LCLYNSKESL SYVVESIEKL RESTLSRREN HIAQLPLSLL LVTKRGVGAL SDIGGETAQS
     LISQGQQVAM KLQCNFLEPA SPGSGYGRNV NERQINQVLK CLLDSRRNAV FRSSSPPPPP
     LPPGIRDMQQ DQSPEADLRI VMCLMCGDSY DVDQLLAPFL LPQHCRPTSP HSSGTSVLLE
     QTVGGHRQTI ELSLLSYHAS FTMRKSRLVH GYVAVYSARR KASFETLCAF LCEVPDIIPV
     QLLAVGETQA ELTDSDFARE MLTQGEDLAR ELEGRFASVV CGPGGVVGGL HRIDLLQPFF
     MEVLEKKTLV EATHMYDNVA EACSMNENVY SPQCGSPSPV TMLLDSEEDM EASPPYHDGT
     LTSHSGFRLP DLDSGDTFSV ISELSTFENK LNNKVPLQVR PRPSVTFDLR KHNFNPYTDP
     ISHRRSLTSN VTWPPAGESI YDPSDYAEPM DAVSKPRPSH EESIYSVPHD STQGKIITIR
     NSNRMHSNGG GNGSDSEGDG SSLERRRKFS TVGVKPRLYR DRSKRLGKFS NFRTSFSIGS
     DDELGVLPKT KEDEVTVLKG ESLIEEGEDP KKRNILRSLR RPGKKTRPKP RHSISKPLES
     TYFGVPLVNV VSPDRPIPLF IDKCIRFIEA TGLTTEGIYR VSGNKAEMES MQKQFEQDHG
     LDLVEKDFSI NTVAGALKSF FSELPEPLVP YSAQVELVEA FKINDREQRL QTMKDVLRRF
     PRENYEVFKH VTSHLNKVSQ WNRVNLMTSE NLSICFWPTL MRPDFTTMDA LTATRTYQTI
     IETFIHQCAF FFYNQAPAES PTGLYGMPGP MVPTALPPSP TAMPSCIPPP PHFSPLLQSP
     PNSPPQSPHT VPPEPQTL
//
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