ID W5K3L7_ASTMX Unreviewed; 590 AA.
AC W5K3L7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Kinesin family member 25 {ECO:0000313|Ensembl:ENSAMXP00000002178.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000002178.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000002178.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR AlphaFoldDB; W5K3L7; -.
DR STRING; 7994.ENSAMXP00000002178; -.
DR Ensembl; ENSAMXT00000002178.2; ENSAMXP00000002178.2; ENSAMXG00000002134.2.
DR eggNOG; KOG0239; Eukaryota.
DR HOGENOM; CLU_001485_2_2_1; -.
DR InParanoid; W5K3L7; -.
DR OrthoDB; 453489at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000002134; Expressed in camera-type eye and 6 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47972:SF66; KINESIN MOTOR DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47972; KINESIN-LIKE PROTEIN KLP-3; 1.
DR Pfam; PF00225; Kinesin; 2.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 171..575
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 441..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 15..42
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 71..98
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 130..157
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 453..467
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 264..271
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 590 AA; 65642 MW; A8905246D0595431 CRC64;
MPLFINRDQI FAHQVHLLEH KLRSKEERIL ELETENALLH LRLAECMGKL RRDQEVEILA
KRRCQLQTNV QKRTRSALAE LLSEVQALKQ DLRDVFALYV SFATDLENQS KQLLEQVAST
AVQVFQGDGI QNLKDQMSAL ERSLQEEKER CRIERTRRRV LHNTLVELRG NIRVHCRVRP
ILPFDCSHSP SRNGSSSPEV VVQAFSDDCV LVNCTKPGSP VTNKMFEFER VHGPEDSQDA
VFEEVKPLLT SLLDGYNVCI MAYGQTGSGK TYTMIGSQPE DSADPKDNSQ QGIIPKATNE
LFNLISEKPA ESHTVEVSVV EVYNNELLDL LAKDEEGASV GVKREVITTS TGTSEVPCLT
HELVESCAEV MQLISAALRL RAHSPTLVHR DSSRSHLIVT LTVSSKSANA LALARRLQNV
RQDVQRGSKR EWWSPRCRRA ASSRSSSPAS SPYPSPCQSP CPSPRPSISQ TPIRTKLQLV
DLAGSECVGM SGVSGAALWE SSCINRSLSA LSDVLGALAE QRPHVPYRNS KLTHLLQDSI
GGDAKLLVML CVSPTQYFLT ESLQSLGFGS RARQIQREPP RRKNTGIKIK
//
