ID W5K3W7_ASTMX Unreviewed; 504 AA.
AC W5K3W7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Solute carrier family 22 member 7b, tandem duplicate 1 {ECO:0000313|Ensembl:ENSAMXP00000002278.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000002278.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000002278.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; W5K3W7; -.
DR STRING; 7994.ENSAMXP00000002278; -.
DR Ensembl; ENSAMXT00000002278.2; ENSAMXP00000002278.2; ENSAMXG00000002230.2.
DR eggNOG; KOG0255; Eukaryota.
DR GeneTree; ENSGT00940000154922; -.
DR HOGENOM; CLU_001265_33_3_1; -.
DR InParanoid; W5K3W7; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000002230; Expressed in head kidney and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR24064; SOLUTE CARRIER FAMILY 22 MEMBER; 1.
DR PANTHER; PTHR24064:SF449; SOLUTE CARRIER FAMILY 22 MEMBER 7-LIKE-RELATED; 1.
DR Pfam; PF00083; Sugar_tr; 2.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 504 AA; 56331 MW; A251E4ECD79E2DB4 CRC64;
MKFENLLAEV GGFGPFQIGI ILMLVIPRVS LPFHFLLNNF IAAIPDHHCD FSSLDTSGVF
ETLSQEQRLT VSIPQHEDGS FSSCHMFSEP QFHLLTNSSN STELPVVQCQ NGWVYDNSTF
KSTLASEWNL VCDKKSMNKA TATIFFSGVM VGAAIFGSLS DRFGRKPMLM VSFISAAFFS
VVSAFSTSYI MFAVMRFFTG MGITGISIIS IVLCEWMIVD YHPLRLYWIP ESARWLIANG
RLEEAHYYLS KCASANHREK SLKVKKMSNL VRKYTYLDLL RTPKLRKLAV VTGITWFGVA
FTYYGISLNV DGFGLNLYLT QFIYGTIELP AKLLIYLSLQ KLGRRYSQVG TLILTGVCIA
ITIIIPKVNW LPRTAVAVLG KGFSEASFTS VFLYTTELYP TVIRQNGLGF CSCLARVGVS
VAPLVSLLQE TWTPLPQVLF CSVAILAGLL ALLLPETHNV RLPETIEDVE QTRHVLILLI
IYGCVSDITT MVLKRRRKNS RAVC
//
