ID W5K4J4_ASTMX Unreviewed; 705 AA.
AC W5K4J4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=RUN and FYVE domain containing 1 {ECO:0000313|Ensembl:ENSAMXP00000002505.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000002505.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000002505.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5K4J4; -.
DR STRING; 7994.ENSAMXP00000002505; -.
DR Ensembl; ENSAMXT00000002505.2; ENSAMXP00000002505.2; ENSAMXG00000002449.2.
DR eggNOG; KOG4381; Eukaryota.
DR GeneTree; ENSGT00940000158334; -.
DR HOGENOM; CLU_014576_3_1_1; -.
DR InParanoid; W5K4J4; -.
DR OrthoDB; 5385125at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000002449; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15758; FYVE_RUFY1; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047331; FYVE_RUFY1.
DR InterPro; IPR047335; RUFY1-3.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45956:SF4; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45956; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 137..269
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 640..698
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 313..371
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 426..516
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 72..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..569
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 79898 MW; 3D078FD1A9297BA0 CRC64;
MRKMADGDPD SAVVNSAVKE ADPDPAPAEP ESAAVEGDGE RRDKAADGSW SAPILSLARK
ATETLSGVNS YGSGWRRSGS VSEQLSPASP TSTDHPDTNR PAIKDPVLVE RSNLLSMMKL
SIKVLIQSSL SLGRTLDSDY PPLQQFFVVL EHCLKHGLKV KKSFIGQNKS IWAPLELVEK
LCPESADLAT SVRDMPGLKT GLGRARAWLH LALMQKKVAD YMKVLINRRD LLSEFYEPGA
LLLEEEGSVI VGMLVGLNVI DANLCVKGED LDSQVGIIDF SLYLKDPQTT ENTQDDSKMT
AILDQKHYIE ELNRHLSCTV TDLQAKMDSL EKTNCKLIEE LSAATDRINA LREEQDQLRQ
ENATILQSSQ RKEEVTLQDS QVELETYRQS RQGLDEMYNV VWTQYKEEKR IRQELQKELE
LQIGLKQEME VAMKLLEKDI HEKQDTLAAL RQQLDQVKTL NLQMFNKAQE AGGVAVKKEE
DAVKLEQKMV QMEKAMKELE LRLQDSENQR KNTEEGQKDL CSEMKGRVEA LQKRMTDLDT
LRSGLEVELS KEKEQRQSLQ RELQREQDNS SELRTQLQQL QGLQTELLDL RHEKKQLQQL
CEEQEQALQE MGLHLSQSKL KMEDFKEVNK ALKGQAWLKD DEATQCKQCQ KEFSISRRKH
HCRNCGDIYC SSCSSNELAL PSYPKPVRVC DICHSLLLQR SSTSS
//
