ID W5K4M1_ASTMX Unreviewed; 1167 AA.
AC W5K4M1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Myelin transcription factor 1 {ECO:0000313|Ensembl:ENSAMXP00000002532.2};
GN Name=MYT1 {ECO:0000313|Ensembl:ENSAMXP00000002532.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000002532.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000002532.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MYT1 family.
CC {ECO:0000256|ARBA:ARBA00010194}.
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DR AlphaFoldDB; W5K4M1; -.
DR Ensembl; ENSAMXT00000002532.2; ENSAMXP00000002532.2; ENSAMXG00000002473.2.
DR eggNOG; KOG3803; Eukaryota.
DR GeneTree; ENSGT00940000156364; -.
DR HOGENOM; CLU_007226_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000002473; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 4.10.320.30; -; 7.
DR InterPro; IPR013681; Myelin_TF.
DR InterPro; IPR002515; Znf_C2H2C.
DR InterPro; IPR036060; Znf_C2H2C_sf.
DR PANTHER; PTHR10816:SF10; MYELIN TRANSCRIPTION FACTOR 1; 1.
DR PANTHER; PTHR10816; MYELIN TRANSCRIPTION FACTOR 1-RELATED; 1.
DR Pfam; PF08474; MYT1; 1.
DR Pfam; PF01530; zf-C2HC; 7.
DR SUPFAM; SSF103637; CCHHC domain; 7.
DR PROSITE; PS51802; ZF_CCHHC; 7.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01143}.
FT DOMAIN 585..832
FT /note="Myelin transcription factor 1"
FT /evidence="ECO:0000259|Pfam:PF08474"
FT REGION 1..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 184..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1045..1100
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..115
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..306
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 366..381
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1167 AA; 130278 MW; 619ED872359E5FBB CRC64;
MSLDIDDKRT RTRSKGGRTP TETVGQELSC PTPGYNGSGH ISGKYARHRS MLSCPVAKKR
RLQEEEEEAE QQQPVSKRKS HPLKLAMDEC FNAESEGSGE EELEVKEEDE VEEGEAQQQC
RDGEHQEEEE QKAESNGAKQ ADEGDEEECV IIEASSTEKP KATGADDIST YQHIVANSLL
HLSNHNNNHV TSPLLQQQQQ LVAVEAQSNS PTRVNNEEEE DEKEEAQTTT VRPTETIRVN
GKTEEEEEEK VDRKGRQEES DHQYFTEEMN MNTRLAENRE NPQNNARRMF EEDYEDEEEE
DEEDEEKEQN TKRNDLPNAS VITTVAQGFL KKEDYITHKP LSAENYTSSN ASVAPLVIEV
RSEGSERDDE DGDDEEEEDN DSLSQRSTVA DESEMYDMMR GNLGLLEQAI ALKAQQVKGH
REFPHIPEHH RYFSLDDRPI KHIEHLRKSY YGKESSRPEK REIKCPTPGC DGTGHVTGLY
PHHRSLSGCP HKDRIPPEIL AMHENVLKCP TPGCTGQGHV NSNRNTHRSL SGCPIAAAEK
LSKSHDKQHL PQPMSEQPKG SPNSDRVLRP MCFVKQLEVP QFGSYRASLL PSTPRANLAK
ELEKYSKVSF DYASFDVQVF GKRMLAPKML TSETSPKAFK TKPPFPRTSS PSPSLQSAYG
KSSSSIHDYS HDAEAAHMAA TAILNLSTRC WERPENLSIK HQDKSMEIEV DENGTLDLSM
KKPIKREGGP LSTSPGVRSP DLSSSSSSSL HHGSSGISPH LQAYKQENWD GPLDYTKPNR
QREEELDEMD HTGQSFASSD PEDCDRLQEC PEDRKYPGEV TTPNFKVKFQ PKECKKELLM
CPTPGCDGSG HITGNYASHR SLSGCPLADK SLRSLMAAHT AELKCPTPGC DGSGHITGNY
TSHRSLSGCP RAKKGGIKTT PTKDDKEDSE LLKCPVPGCD SLGHISGKYA THRSAYGCPL
AARRQKEGLL NGTPFSWKAF KTEGPTCPTP GCDGSGHANG SFLTHRSLSG CPRASLAKKK
AKFPGEEYLS NKFRASDVLD NDEDIKQLNK EISDLNDSNN EMEADMANLQ TQISSMERNL
KNIEHENKII EEQNEALFME LSGLSQALIR SLANIRLPHM QEPITEQNFE KYVSTLTDMY
TNKDCYQNPE NKALLETINQ AVKGIKV
//
