ID W5K5M5_ASTMX Unreviewed; 1126 AA.
AC W5K5M5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Beta/gamma crystallin 'Greek key' domain-containing protein {ECO:0000259|PROSITE:PS50915};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000002886.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000002886.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta/gamma-crystallin family.
CC {ECO:0000256|ARBA:ARBA00009646}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; W5K5M5; -.
DR STRING; 7994.ENSAMXP00000002886; -.
DR Ensembl; ENSAMXT00000002886.2; ENSAMXP00000002886.2; ENSAMXG00000002813.2.
DR eggNOG; ENOG502R2J7; Eukaryota.
DR GeneTree; ENSGT00940000157740; -.
DR HOGENOM; CLU_002147_1_0_1; -.
DR InParanoid; W5K5M5; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000002813; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.20.10; Crystallins; 6.
DR InterPro; IPR001064; Beta/gamma_crystallin.
DR InterPro; IPR011024; G_crystallin-like.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR PANTHER; PTHR11818; BETA/GAMMA CRYSTALLIN; 1.
DR PANTHER; PTHR11818:SF42; RICIN B-TYPE LECTIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00030; Crystall; 6.
DR PRINTS; PR01367; BGCRYSTALLIN.
DR SMART; SM00247; XTALbg; 6.
DR SUPFAM; SSF49695; gamma-Crystallin-like; 3.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50915; CRYSTALLIN_BETA_GAMMA; 7.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 456..502
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 626..672
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 673..715
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 768..810
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 821..858
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 859..902
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT DOMAIN 949..990
FT /note="Beta/gamma crystallin 'Greek key'"
FT /evidence="ECO:0000259|PROSITE:PS50915"
FT REGION 1..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 343..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..146
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1126 AA; 124991 MW; EAEDEE06DA07B1E3 CRC64;
IREKFCMLND NESELAGGRR RWEEPVTPAG EGGITNTGSD SHAQQTEQSD SYFSGVFKAT
RVELPSSPTD ALPDLDPDTS MPASPHDMDT LLDTLKSMGP PVRHRTLRNS SSQPFSSLPP
IVEDAPSPSS VPLSSPTSPE PKPLSSLPPD LGLNWSSMKD MRSPLTMMKE QQASELSSRS
LILPSRASTI SSIVMRKSSL PDLTSEHGSL TNGGGSLLGP SRLDHSLIFS SYRSEHDGSQ
GSQDGKALGS RSLFRTASLP EVSSSLDRLS MPPKSIEQLG SGTSRFDRLS FLTSPPGSLT
GLNEMSSRMS VSPSFLQNNA TVESPTFNHT PPSSLELFRT LSPESPVKHQ PPPSLQRSLS
SEGHSAGSPV FNGAMRGFGA PQEQAPERNF VAKYRAFPDA YLTKEKEHGK LNPRPGKMFI
FNRPGLRGQR TEIRGDVMDA TAWQFPESIS IRVVRGGWVL YEKPDFKGEK IALDEGDIEL
TYPWSPAEDQ HGPTQNGMQG SEEESSEPKP PARRQFIIGS LRRAVRDYSV PEICLFPEEN
AEGKKIVFRD TSEDARIFGF PIKANSIIIN AGLWLVFAEP FFQGDPRVLE VGGFPNPAAW
GVSQPYVSSV HPLKIGEPKV EKPNEPKLVI YEKPYFTGKS REIFTNSRDF MSRESNQQQA
FMFNAGSIKV IGGIWVGYEK EGFRGHQYLL EEGEYHDWRV WGGCDSELRS VRVIRTDLSQ
PTLVMFEMTT EEEEQEQEER TFEVTEAVPD VELFGFRPAT RSIHVLSGAW VAYSHVDYSG
HQFVLEKGFY NNCADWGSED NRICSIQPIL QAPAYGPKIQ NELLLFSEPG FQGKCRAFTQ
SHDSLPESLP VQSCRVVGGS WVFYDDSNYM GNQYVLSEGD YANFISIGCP ANYSLRSIKS
VPMMFSVPSI SLFGLECFEG REVTVESEVS NMIEDGFNPH VLSVRVNSGC WVLCEHANYR
GRQYLLEPIE ITNWHKFSSL STIGSMYPIR AKRKLFRIRY KETGHYMSVQ GGVDTMKSGR
VVVSEQVEGM SDIWFYQDGL LKNKLAPTMS LQVMGSVESG SKVVLWSETR TPVQIWSAQL
SGAISSLTFP GLVLDVKGGK TYDKEHVIVQ SEGEESAAEL WELELL
//
