ID W5K6J9_ASTMX Unreviewed; 779 AA.
AC W5K6J9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Spondin-1 {ECO:0000256|ARBA:ARBA00019594};
DE AltName: Full=F-spondin {ECO:0000256|ARBA:ARBA00030964};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000003210.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000003210.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5K6J9; -.
DR STRING; 7994.ENSAMXP00000003210; -.
DR Ensembl; ENSAMXT00000003210.2; ENSAMXP00000003210.2; ENSAMXG00000003147.2.
DR eggNOG; KOG3539; Eukaryota.
DR GeneTree; ENSGT00940000154910; -.
DR HOGENOM; CLU_014540_1_0_1; -.
DR InParanoid; W5K6J9; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000003147; Expressed in brain and 6 other cell types or tissues.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 2.60.40.2130; F-spondin domain; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR InterPro; IPR009465; Spondin_N.
DR InterPro; IPR038678; Spondin_N_sf.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR NCBIfam; NF038123; NF038123_dom; 1.
DR PANTHER; PTHR11311; SPONDIN; 1.
DR PANTHER; PTHR11311:SF16; SPONDIN-1; 1.
DR Pfam; PF02014; Reeler; 1.
DR Pfam; PF06468; Spond_N; 1.
DR Pfam; PF00090; TSP_1; 6.
DR SMART; SM00209; TSP1; 6.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS51019; REELIN; 1.
DR PROSITE; PS51020; SPONDIN; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..779
FT /note="Spondin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017442733"
FT DOMAIN 33..201
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 201..391
FT /note="Spondin"
FT /evidence="ECO:0000259|PROSITE:PS51020"
FT REGION 697..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 779 AA; 87270 MW; 5C1B9999139ECC3B CRC64;
MRPRVRSCPR SRALLLLLHG LLVAGLPRAA LAFTEEPVER VAKPDAFCSW ILRAQPQGAR
KEGHSEFRLR VEGDPEHYQP ASTYRVTLYA TNPAYFRGFT LIALKEGRNG EKEEDYAGNF
QIIDEEDTQF MTNCPPAVTE STPRRRTRIQ VFWTAPPSGS GCILLKASIV QRKIISFQDE
GSLTKRMCEK ESLYGESTDK PLLDCCACGT AKYRVTFYGN WSEKLHPKDY PRRANHWSAI
IGSSHSKNYV LWEYGGYASD GVKQVAELGS PVKMEEEIRQ KGDEVLTVIK MKAQWPAWQP
LNVRAAPSAE FSVDRSRHLM SFLTMLGPSP DWNVGLLSSP VGRCGWPWNS ICSPNKPTVP
QEKIRPLTSL DHPQSPFYDP EGGAITQVAR VVVERIARKG EQCNIVPDNV DDIVADIAQE
EKEEDDTPET CIYSNWSPWS ACSSSTCEKG KRMRQRMLKA QLDLSVPCPH TQDFEPCMGP
GCSDEDATTC MMSEWITWSP CSVSCGLGMR SRERYVKQFP EDGFACTLPT EETEPCTVNE
DCSPSSCLVT EWGEWDACSA TCGLGMKRRE RMVKMPPSDG SICGAEVVEV EKCMMPECHT
IPCLLSPWSD WSDCSVTCGK GTRMRQRILK SPRGLSKCDQ TTLISFCPSV SAASDCMMSD
WSEWSECNKS CGKGDPCAET VQRKKCKIRK CSQGGANSEE RKKRKEARKK RKNKQGREEG
GDELAGCKMK PWSGWTDCTK LCGGGIQERL MTAKKRFKST QLNSCKDRKE IRACNVHPC
//
