ID W5K6M8_ASTMX Unreviewed; 1327 AA.
AC W5K6M8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Roundabout guidance receptor 3 {ECO:0000313|Ensembl:ENSAMXP00000003239.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000003239.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000003239.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSAMXT00000003239.2; ENSAMXP00000003239.2; ENSAMXG00000003091.2.
DR eggNOG; KOG4222; Eukaryota.
DR GeneTree; ENSGT00940000155457; -.
DR HOGENOM; CLU_003227_5_1_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000003091; Expressed in brain and 9 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008046; F:axon guidance receptor activity; IEA:InterPro.
DR GO; GO:0016199; P:axon midline choice point recognition; IEA:InterPro.
DR GO; GO:0035385; P:Roundabout signaling pathway; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd05725; IgI_3_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR032986; Robo1_Ig-like3.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF37; ROUNDABOUT GUIDANCE RECEPTOR 3; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 806..828
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..67
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 73..160
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 165..249
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 254..347
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 358..444
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 465..560
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 579..671
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 676..775
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 964..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 964..997
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1054
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1254..1283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1327 AA; 144895 MW; 18173E6C927DC8E6 CRC64;
MVEWYKDGER VDTDREDPRS HRMLLPTGSL FFLRIVHGRR SKPDEGVYVC VARNYLGEAV
SRNASLEVAI LRDDFRQTPS DVVVAAGEPA VMECIPPRGH PEPTISWKRN NVKVNDKDER
ITIRGGKLMI SNTRKSDAGM YVCVGTNMVG EKDSDPAELV VFERPMFVRR PVNQVVLADD
TVDFQCEVQG DPAPTIRWKK EEGELPRGRS EIRSDNSLRL TQVKEEDEGS YTCVSENSVG
KAEASGTLQV HVPPQIVVRP RDQISAPGRT VTFLCGTKGN PPPAVFWQKE GSQILLFPSQ
PPAQSGRFSV SLSGELTISD VHSEDSGYYI CQAISVAGSI LTKALLEVED APSDRIPPII
RQGPANQTLV PGTTAQLQCY VMGNPLPSIQ WERDGQRILG NDERVTLMDN GTLQITALQE
TDSGVYTCVA SSSSGETSWS GVLTVKDSGG MTLAPASEPY QLPGPPQKPV VTDVTKNSVT
LTWQPNAHEG GAAVTSYIIE AFSQSAGSTW QTVADLVRLE KHTVNGLSPN TIYLFIVRAV
NAYGLSDPSP ISEPVRTQDV SPTGQGVDHR QVQRELGEVA VELQQPVLLT ASSVQLAWTV
DRQSQYIQGY RLLYRPVGGS WLQQDVKAAP ERSAVLSNLL KGTEYEVKIR PYFNEFQGMD
SRLLTLRTPE EVPSAPPQAV TVSTVKLSNS SSISVTWQPP PTEMQNGVIQ EYRIWCLGND
SQTRYHINQT VDGNVLSTLV KGLLPGVLYL VEVAAVTSAG VGTHSQPVSV TIKLPAEQPA
VPSGGGDSDQ NVSLAEQITD VVKQPAFIAG IGGACWVILM GFSVWIYCRR KKRKELSHYT
ASFAYTPAVG FPHGEASGLN GRPGVLGSNM GNYPWLADSW PTTNLVHNGK DSVNCCTTKH
DTTERYYNEV GISNYLNQTE KYSTGSNEGP IYSTIDPTAE DLRSFSAQYS QHTTPYASTP
IMPFTNQAPC SPEQDGGHWI NQPGTSNVQY AQPDRSKSDN AKQSKQKSMG KAVKTPSLNW
IEPLPPPPPS GDLDHCEDED EDEHIEDIGT DEEDWCPPLP ERTYLIDGVA EDGPCPPPRG
DASSPATSYS HQSTATLTPS PREEARHCQD IPRLHHPEQS QSGRRLPCGP VPIPRAPSPP
LTQSNPNLTA NQEGPESGTP QRSTHRREWS QGAAQSTDNV NTPGRARTSA GEQAQTPPGQ
KARVKKKTSK SGQYRRDIMQ GDLPPPPEPP PEDELLSAGG FECGQTSLER DGGSLSSMER
RDHNTPNRKN SAQRRKDDED LIPYNKPNFL SRGQMSSNCS TTGSSSSRGS TGSRGQGNSR
KRNEEMR
//
