ID W5K8M5_ASTMX Unreviewed; 506 AA.
AC W5K8M5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Polypyrimidine tract binding protein 3 {ECO:0000313|Ensembl:ENSAMXP00000003936.2};
GN Name=PTBP3 {ECO:0000313|Ensembl:ENSAMXP00000003936.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000003936.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000003936.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5K8M5; -.
DR STRING; 7994.ENSAMXP00000003936; -.
DR Ensembl; ENSAMXT00000003936.2; ENSAMXP00000003936.2; ENSAMXG00000003686.2.
DR eggNOG; KOG1190; Eukaryota.
DR GeneTree; ENSGT01050000244924; -.
DR HOGENOM; CLU_015171_7_1_1; -.
DR InParanoid; W5K8M5; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000003686; Expressed in olfactory epithelium and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR006536; HnRNP-L/PTB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR PANTHER; PTHR15592:SF17; POLYPYRIMIDINE TRACT-BINDING PROTEIN 3; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF13893; RRM_5; 1.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50102; RRM; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 24..98
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 312..386
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 429..504
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 506 AA; 55540 MW; 57D172FB14DED7E5 CRC64;
DKHLIPSTTD IKTYKGDRSC GPSRVVHVRK VPIEVSEAEV ISLGIPFGKV TNLLMLKAKN
QAFIEMASEE AAITMVNYYT TATPHVRNQP VYIQYSNHRE LKTDNLPNQG VRSPSTLSVL
PVLDQCAAFF YRQAASPKYI RTCGIIVTHK YYKCCSFLYL YVGLFGSNYI TKTNNSNNKF
MAVHLLRLTP ITLDGQNIYN ACCTLRIEFS KLTSLNVKYN NDKSRDFTRL DLPSGDGQPT
LDPGMTAAFG APGIISSPYA GAAGFAPAVG FPQAAGLSMQ AMPGALGPLT IPPSAVAGRM
AIHGMAPTAL HSVLLVSNLN PDSISPHSLF ILFGVYGDVH RVKILFNKKE NALVQMADAT
QAQLAMSHLN GQRLHGRVIR VTISKHQTVQ LPREGQEDQG LTKDFSGSPL HRFKKPGSKN
FQNIFPPSAT LHLSNIPPSI ADDMLKDLFS SAGYTVKAFK FFQKDRKMAL IQLGSVEEAI
QALIDLHNHD LGENHHLRVS FSKSTI
//
