ID W5K9V9_ASTMX Unreviewed; 621 AA.
AC W5K9V9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Protein tyrosine phosphatase domain-containing protein 1-like {ECO:0000313|Ensembl:ENSAMXP00000004370.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000004370.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000004370.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5K9V9; -.
DR STRING; 7994.ENSAMXP00000004370; -.
DR Ensembl; ENSAMXT00000004370.2; ENSAMXP00000004370.2; ENSAMXG00000004263.2.
DR eggNOG; KOG1720; Eukaryota.
DR GeneTree; ENSGT00940000165406; -.
DR HOGENOM; CLU_019730_0_0_1; -.
DR InParanoid; W5K9V9; -.
DR OrthoDB; 316722at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000004263; Expressed in camera-type eye and 11 other cell types or tissues.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14506; PTP_PTPDC1; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR049573; PTPDC1_PTP.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR23339; TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR23339:SF93; ZGC:77752; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 56..221
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 143..210
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 380..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 621 AA; 69521 MW; 8CA1949F44E6EAEF CRC64;
MTLLVPVPKP SYSQTRENLV KAIPPKIICL LACGGRDCRY EGPACWRTSQ QAIRGLFSSW
VTNDIIAMAR PSTNLIKRYN IIEQFKKLNI KSIINMQLPG EHAHCGPDLE PDSGFTYSPQ
VFMENQIYFY NFGMTDFGVS SIVGMLDAVK VLTFSVEEGK VAVHCHAGLG RTGVLIACYL
IYMLRITASE AIHYVRIKRP RSIQTRAQIS LVFDFARLIG SQLAQYPCLN MRHGAPFTLR
QYLQRQALLL HGEEARTLAH TPKILHLLCS LLTAIAQGAL SPPEVQLHLK RKAAVLALQA
DVRETLVLHR YLPVLTEGEG PVSSWDEPLG FLERKRAVLL NKRSYSESDL SKITLSKNFG
FIQFSTSFMD DGKVCNGHFR DQRSSTPASD ILTKESNSST DRYTPIAPSS PRMCDTRAAK
RAKFMMKRAQ PFSKFSSTIE LCKNHESGKV SLSSKEVAEA MAQQDQPGDK ILQRAAKLQD
ELNLSAYGWA TLTMEADPKV LSTLMWVWLE KIKDPILSAD DIDKLCTNTP SQNPLRTLYK
SQRSTLCCLL SCVGQVTTHC PQTETAVLQR LIRALTRRPP EEIARSDTVM KLFRSTVREL
QCVRPATGSP TTNTSSLQQF I
//
