ID W5KAC6_ASTMX Unreviewed; 851 AA.
AC W5KAC6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Tetratricopeptide repeat domain 7A {ECO:0000313|Ensembl:ENSAMXP00000004537.2};
GN Name=TTC7A {ECO:0000313|Ensembl:ENSAMXP00000004537.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000004537.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000004537.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; W5KAC6; -.
DR STRING; 7994.ENSAMXP00000004537; -.
DR Ensembl; ENSAMXT00000004537.2; ENSAMXP00000004537.2; ENSAMXG00000004414.2.
DR eggNOG; KOG4162; Eukaryota.
DR GeneTree; ENSGT00940000158638; -.
DR HOGENOM; CLU_010512_0_0_1; -.
DR InParanoid; W5KAC6; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000004414; Expressed in intestine and 9 other cell types or tissues.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR045819; TTC7_N.
DR PANTHER; PTHR23083:SF475; TETRATRICOPEPTIDE REPEAT PROTEIN 7A; 1.
DR PANTHER; PTHR23083; TETRATRICOPEPTIDE REPEAT PROTEIN, TPR; 1.
DR Pfam; PF19440; TTC7_N; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 38..429
FT /note="Tetratricopeptide repeat protein 7 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19440"
FT REGION 628..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 851 AA; 94240 MW; 8E72E219E46D2324 CRC64;
MANLCKEHET AKSIFRRLEC AVTPLVSGDY GHRDIAGMSS RISFSQYRLE AEIERCRAEC
QWDKIPPLLE QLAAARLHEH DDYGTLLLAE ALLEECLLEN VALLKNCTPL SENNQPKLAR
AKAHLNSIMS KGRLEPRYLN EALLLLAKVH YVQGRYRDAQ GMCARAGIED FTRDEQPIYH
LRLLAEAFVI KGLSLDHQTM SAASRVRLSE REEECLSCYL RACDTALLYL QELDKTVSTP
SAKTAKSSVS APPAEMDPGY FLQAALQSAY LCLLHKGHLA QGTHQLRLVL RVVESRGSQS
FRKGVSRKLA EVLLSSVSED SYWGPLSHPP PAWLHMEGAT HPKDTIYPSS RPPQRYNTEG
AFCPQDVVEE AVLLLLITES MASGEAVISR TPEHQEAREA SMQEASSVYD LLSIGMARRG
QYAMLSQCLE RAMKFSFNEF HLWYQLGLSL MASGKLEEAQ ALAQSVVALG EEAEESLAKA
HLAIGLCCSL RASDATLKGD RDEFNRRALQ ALQKAHETDP QDPQIALYLS LQLALVRQVS
AAMEPLQLAL SLHSDDLHSL HLLALLLSAQ KHHQHALDTL IVALNQFPDN FNLLFTKVKL
EEALYGPAVA LQTCEDMLQL WQSRYDYARP SEPDDTSSIP PPEPSPISRK SSGLHLTLPD
FQETETGSQR SASVAVSRLE QAMSEVSAIS STHRQGPAYV WTTLERIWLE AGELFMADGR
VKEAQFCVQE AGALYPTSHS VLLLKGQLAE LRGNDVEAKS LYDEALAINP TGQHILIHLG
KLLVRTGRAG LGEKVLRDAV QAHSVSHEAW SGLGEALQSR SSTQAPDCFL TALELEASCP
IRPFTIIPRE L
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