ID W5KAH5_ASTMX Unreviewed; 910 AA.
AC W5KAH5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000004586.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000004586.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. GRIK2 subfamily. {ECO:0000256|ARBA:ARBA00038119}.
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DR RefSeq; XP_007238229.1; XM_007238167.2.
DR AlphaFoldDB; W5KAH5; -.
DR STRING; 7994.ENSAMXP00000004586; -.
DR Ensembl; ENSAMXT00000004586.2; ENSAMXP00000004586.2; ENSAMXG00000004419.2.
DR GeneID; 103044887; -.
DR KEGG; amex:103044887; -.
DR eggNOG; KOG1052; Eukaryota.
DR GeneTree; ENSGT00940000155610; -.
DR HOGENOM; CLU_007257_1_1_1; -.
DR InParanoid; W5KAH5; -.
DR OrthoDB; 511851at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000004419; Expressed in brain and 5 other cell types or tissues.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd06382; PBP1_iGluR_Kainate; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF38; GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|RuleBase:RU367118};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT CHAIN 34..910
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT /id="PRO_5027154867"
FT TRANSMEM 565..584
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 641..663
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 822..846
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 434..803
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 444..509
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 910 AA; 102402 MW; 13B70FF9F3DE55A4 CRC64;
MMSGSAARLA APMPGSSPCL LLPLMLLLGW SLGMPHVLRF GGIFESIESG PSGAEELAFK
FALNTINRNR TLLPNTTLTY DIQRINVFDS FEASRKACEQ LSLGVAAIFG PSHSSSANAV
QSISNALGVP HIQTRWKHQV SDNRDSYYVS LYPDFSSLSR AILDLVHFFR WDSVTVVYDD
STGLIRLQEL IKAPSRYNIR LKIRQLPAET KDAKPLLKDM KKSKEFHVIF DCSHEMAAWI
LKQALSMGMM TEYYHYIFTT LDLFALDMEP YRYSGVNMTG FRILNTESPQ VSSIVEKWSM
ERLQAPPKPD SGLLDGFMTT DAALMFDAVH VVAVAVQQSQ QITVSSLQCN RHKPWRFGGR
FMSLIKEASW DGLTGRVLFN KTNGLRTEFD LDVISLKEDG LEKIGTWEPV NGLNMTEHHK
SKMTNVTNSL SNKSLRVATI LEEPYVMFKK SDKPLCGNDR FEGYCVDLLR ELASILGFRY
EIQLVEDGKY GALEESTGQW NGMVRELMDH KADLAVAPLA ITYVREKVID FSKPFMTLGI
SILYRKPNGT NPGVFSFLNP LSPDIWMYIL LAYLGVSCVL FVIARFSPYE WYNPHPCNPD
SDMVENNFTL LNSFWFGVGA LMQQGSELMP KALSTRIVGG IWWFFTLIII SSYTANLAAF
LTVERMESPI DSADDLAKQT KIPYGVVEDG STMAFFKKTK ISTYDKMWEF MNSRRQSVMV
KSVEEGIQRV LTSDYAFLME STTIEFVTQR NCNLTQIGGL IDSKAYGVGT PMGSPYRDKI
TIAILQLQEE GKLHMMKEKW WRGNGCPEEE SKEASALGVQ NIGGIFIVLA AGLVLSVFVA
VGEVLYKSKK NAQMEKRSFC SAMVDELTVS LKCQRRLKQK PQPPAIVKTE EVINMHTFND
RRLPGKETMA
//
