GenomeNet

Database: UniProt
Entry: W5KBL7_ASTMX
LinkDB: W5KBL7_ASTMX
Original site: W5KBL7_ASTMX 
ID   W5KBL7_ASTMX            Unreviewed;      4703 AA.
AC   W5KBL7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   16-JAN-2019, entry version 30.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSAMXP00000004978};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000004978, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000004978, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000004978};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000004978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000004978};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D.,
RA   O'Quin K.E., Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C.,
RA   Volff J.N., Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000004978}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   Ensembl; ENSAMXT00000004978; ENSAMXP00000004978; ENSAMXG00000004818.
DR   GeneTree; ENSGT00940000155507; -.
DR   OMA; MVTCTLK; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 2.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 3.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4246   4266       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4305   4331       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4455   4480       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4503   4525       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4584   4607       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      127    172       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      180    234       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      240    303       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      305    364       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      516    741       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      957   1152       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3778   3804       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      424    444       {ECO:0000256|SAM:Coils}.
FT   COILED     1684   1704       {ECO:0000256|SAM:Coils}.
FT   COILED     3145   3165       {ECO:0000256|SAM:Coils}.
FT   COILED     3311   3331       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4703 AA;  533418 MW;  7C4CD12E384E9DB7 CRC64;
     RGQSGKDDEV VLQCVATIQK ENRKFCLSAE GLGNRLCYLE PTSEAKYVPP DLCICNFVLE
     QSLSVRALQE MLANTGQNGE GAGQGGGHRT LLYGHAILLR HSFSGMVRMR EACWWTIHPA
     SKQRSEGEKV RIGDDLILVS VSSERFLHLS MSNGNIQVDA SFMQTLWNVQ PTCSGSNVAV
     GYLLGGHVIR LFHGHDESLT VPGSDQSGEQ QRVANYEAGK GGSRARSLWR LEPLRISWSG
     SHIRWGQPFR LRHLSTGHYL GQTEDRGLVL LDREKSDTTA TAFCFRPSKE KVDSGSKRDI
     EGMGVAEIKY GDSVCFIMHV ATGLWLSYQA PDAKSSRLGL LKRRAFLYPE GHMDDGLILQ
     LCQHEESRAA RIIRNTTQLF TQFIRYSISV PVTASEVSLP VGEVMQTLDD LITYFQQPDP
     DLEHEEKQRQ LRSLIKRQDL FKEEVSLFIC RLLIWVQLSN HLLYIILHAT ALIQGNRPNC
     TQFSRKLDWL ISKLERLESS SGILEALHCI LTESPEALNI IQKVHIKSII SLLYKHGRNH
     KILDILCSLC VCNGVAVRTN QNFISEHLLP RRDVLLQTKL VNDVQSMRPN IFLGMSEGSA
     QYRKWYFELI IDQVDHFVTG EPTHLRVGWA TTKGYAPYPG GGEGWGGNGV GDDLYSYSFD
     GLHLWSGRIP RAVASINQHL LTSDDVVSCC LDLGAPSMSF RINGQPVQGM FEDFNTDGFF
     FPVVSFSAGV KVRFLLGGRH GDFKFMPPAG YAPCYEALLP KEKMRVEPVK EYKRDLEGVR
     DLLGTTKLLS QASFIPIPVN TAEIVLPPHL ENVRDKLAEN IHELWGMNKI ELGWTYGKIR
     DDNKRQHPCL VDFSKLPETE KNYNLQMSTE TLKTLLALGC HVAQVQVDAE EDLKRIKLPK
     DYMMSNGYKP APLELSEVKL TPGQEVLVDK LAENAHNVWA KDRIKQGWTY GIQQDLKSRR
     NPRLVPYALL DERTKKSNRD SLREAIRTLI GYGYNIDPPD QETANVIEKL NVENIRFFRV
     EKTYAVTSGK WYFEFEAVTG GEMCVGWARP GCRPDIELGL DDQAFVFDGC RGRRVHMGSH
     FFGRSWNKGD VVGCMINMED KSMIFTLNGE ILITNRGSEL CFADFDTEGG FIPVCSLGLS
     QIGRMNLGKD ASTFKYYTMC GLQEGFEPFA VNMNRDVTMW FSKRLPTFVN VPEDHKHIEV
     TRIDGTVDTP PCLKVTHRTF GTQASNNDMI YCRLSMPLFC RSEGSISDSH FFAFFLQYFY
     SVRVFAGQDP AAVWVGWVTP DYHYYSKHFS LNKVRTVTVT LGDERGRVHE SVRRSNCYMV
     CAGEISNSSS GRSNTDLESI KVSCALQLKI MSVVFLPSPL WRYYQVEPNT KLFPAVFIEP
     TSPNLFQFEF PKIQDAMPLS SAIFKSLHRN PEPQCPPRLD VQTIVSVLWS RMPNSFLSVE
     TARVSERHGW VVQCLEPLQM MAVHIPEENR CIDIMELSEN EDLRMFHYQT LKLYCALCAL
     GNTRVAHALC SHLDQSQLLY TIDNQYLTGQ LREGFYDVLI SICLETAKEA RLMMNNEFII
     PVTDETRSIR LFPDESKRHS LPGVGLSTSL TPRLNFNPPC FITTKREHTY SPQIPLGILK
     EKAISMLTEA VQGGGTHIRD PVGGSVEYQF VPILKLIGTL LIMGALTSEE VRLILLLIEP
     NVFADNKEEE KPAAEEAVEK EEASSNEEKT VEAGEEESKD SKQAPKGLLE KSLPEPVKRQ
     MCELLNYFCD CELKQRIEAI VAFSDHFVAK LQYNQKFRYN ELMQAFNMSA AVTAKKTKEF
     RSPPQEQINI LLNFSAGEDC PCPEEIQEEL QNFHDDLRLH CGIPMEEEEE EQDTSIKGRL
     LSLLYKIKGR PQKTEEEPSE QEQATPTNLK ELISQTMVSW AQECTIQDPE LVRIMFSLLR
     RQYDGIGELL RAMRKSYTIS EKSVQDAINL LASLGQIRSL LSVRMGEEEG QLMIDGLGDI
     MNNKVFYQHP NLMRVLGMHE TVMEVMVNVL GGDKSKIAFP KMVASCCRFL CYFCRISREN
     QKAMFDHLSY LLENSSVGLA CPAMRGSTPL DVAASSVMDN NSLALALEEP DLEKVVTYLA
     GCGLQSCPML VAKGYPDIGW NPIEGERYLS FLRFAVFVNG ESVEENANVV VKLLIRHPEC
     FGPALRGEGG QGLLAAMLEA IKISEDPTLD LPNLIGEDGE EEEVAHMGNS IMSFYSALID
     LLGRCAPEMH LINKGKGEAL RIRAILRSLV PIKDLVGIIS IPLKVPVINK DGTVTEPDMN
     SSFWPDHKSP MVLFLDRVYG IEDQSFLLNL VEVGFLPDLR ASASLDTVLS TTETALAMNR
     YIGSAVLPLL TRCASLFAHT EHYAQLVDST LHTIYRLSKG RSLTKAQRDS IEECLLAICQ
     HLRPSMLQQL LRRLVFDVPQ LTEYCKMPIK LLTNHYEQNW KYYCLPSGLG SYGMASEEEL
     HLTKKLFWGL FDALSQKKYD SELFKMAMPC LSAIGGALPP DYVDTSPTTT LVKQVSVDTQ
     GNFDPKPINT ANISLPEKLE YIANKYAEHC HEKWSSEKFA QGWTAGEKVN EQAKTHPLLK
     PYKALSEKDR ETYRYPVKES LKSMLAMSWN IERTKEGEAM FQQRETEKLK TTEPSQGDGF
     NPTPVDLDNV ILSRELQSMV ETVAENYHNI WAKKKKMELS SKGGGTHPLL VPYDTLTAKE
     KYRDREKAQE LFKFLQLNGY ALSRGFKDME QDSSSMEKRT AYKFLKRLLS YVDSAQEFIA
     HLEAMASSGK TDKSPHEQEI KFFAKVLLPL IDQYFKNHCL YFLSSPSISL SSSGYASNKE
     KEMITRFSIL LQSLTARSDS ATMVSCLHIL ACSLDFRTVM KSGSELVKAG VRTFFENAAE
     DLEKTMENLK LGKLGQSRTQ MKGVAQIIVY TSTALLPILT ALFQHVTQHQ FGVDLLLDDV
     QLSCYRILTS LYSLGTGKNS YVEKQLPALG ECLATLVGAM PVAFLEPDLN MHNPCSVFNT
     KTPRERAILS MPDTVEEMCP EMPRLDGLMK DIHDISESGA RYTDMPHVIE VILPMLCNYL
     SYWWEKGPEN SPSDMDCCTT VTSEHLSLIL GNILRILNNN LGIEEASWMK RLAVYTQPII
     SKAGADLLRT HFLPTLEKLK KKTVKVVSEE ELLRAESRAD TQEAELQILD EFAVLCRDLY
     AFYPMLIRYV DNNRSKWLKK PHADSTELFK MVAEIFILWC KSHNFKREEQ NFVVQNEINN
     LAFLTGDSKS KMSKSGGQDQ ERRGKKRKRE LYSVQTSLIV SAHKKLLPIG LNMCTPGDQM
     LISLAKIRYC LKDTDDEVKD HLKQNLHLQE KSEDPGVQWQ LNLYKDVEMK SEEASDVEHT
     VERIQGISAA VFHLEQVELP LRNKKLVAQK LLSKQRKRAV VACFRMKTPM VVEKEEEEAE
     AEVQPDPLNQ LILHFSHNAL TERSMCICYE FIIHCVCLPS QEKEMEKQKT LYQQARLHAR
     GAAEMVLQMI SASKGRLGPM VTCTLKLGIS ILNGGNVVVQ QKMLDYLKEK RDAGFFKSLS
     GLMMSCSVLD LNAFERQNKA ESLGMVTEEG SSSKVLQNDD FTKDLFRFLQ LLCEGHNNDF
     QNFLRTQTGN TTTVNIIIST VDYLLRLQES ISDFYWYYSG KDIIDEQGQR NFSKALAVAK
     QIFNSLTEYI QGPCIGNQQS LAHSRLWDAV VGFLHVFANM QMKLSQDSSQ IELLKELMDL
     QKDMVVMMLS LLEGNVVNGT IGKQMVDTLV ESSSNVEMIL KFFDMFLKLK DLTTSDNFKE
     YDPEGKGMIS KKEFQKSMES QKQYTQSEIE FLLSCTEADE NDMFNYAEFV ERFHEPAKDI
     GFNVAVLLTN LSEHMPHDSR LGTFLDLAES VLSYFEPYLG RIEIMGGAKR IERVYFEISE
     SSREQWEKPQ VKESKRQFIF DVVNEGGESE KMEMFVNFCE DTIFEMQLAS QISEQDAAER
     PEEEEEELQS LLEELAEGED GSQESASAFT LACTSVKKKM SNFRQMLTIK SMRKQFKKFK
     KLTIKEMITG FFSFFWMLFT GFFKGIFGLI FGFFHIIWSS MFGGGLVEGA KNMKVTDILG
     NMPDPTQFGI HGDVLEAEKM ESSDFVVSTE MVQMAGAGDK MEPDSIIDLI NPAPKREGKH
     GPETGLGDVS EIMTEVSQPV EKKKSQVCIL SVHIWKYEIL FNTEHQEKED KAKEEKPEEP
     VVEEKPAPRK RHGTAKEAAP AFMASFFAGL EVYKTKMLNY LARNFYNLRM LALLVAFAIN
     FILLFYKVSG ETEEEEEDES PWGGDDEDED GGGMEFFVLQ ESTGYMAPTL TFLAVLHTII
     SLLCVVGYYC LKVPLVVFKR EKEIARTLEF DGLYITEQPS DDDIKGQWDR LVIATPSFPN
     NYWDKFVKRK VINKYGDLYG AERIAELLGL DKSALDFDPT EEAVVKEASL LSWLSSIDTK
     YHIWKMGVVL TDNSYLYLIW YTTMSILGHY NNFFFAAHLL DIAMGFKTLR TILSSVTHNG
     KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN KSEDEDAPDM KCDDMMTCYL FHMYVGVRAG
     GGIGDEIEDP AGDPYELYRI LFDITFFFFV IVILLAIIQG LIIDAFGELR DQQEQVKEDM
     ETKCFICGIG NDYFDTTPHG FETHTLQEHN LANYLFFLMY LINKDETEHT GQESYVWKMY
     QERCWDFFPA GDCFRKQYED QLG
//
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