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Database: UniProt
Entry: W5KBW7_ASTMX
LinkDB: W5KBW7_ASTMX
Original site: W5KBW7_ASTMX 
ID   W5KBW7_ASTMX            Unreviewed;       755 AA.
AC   W5KBW7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 59.
DE   RecName: Full=PR domain zinc finger protein 1 {ECO:0000256|PIRNR:PIRNR013212};
DE            EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR013212};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005078.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000005078.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Transcription factor that mediates a transcriptional program
CC       in various innate and adaptive immune tissue-resident lymphocyte T cell
CC       types such as tissue-resident memory T (Trm), natural killer (trNK) and
CC       natural killer T (NKT) cells and negatively regulates gene expression
CC       of proteins that promote the egress of tissue-resident T-cell
CC       populations from non-lymphoid organs. Plays a role in the development,
CC       retention and long-term establishment of adaptive and innate tissue-
CC       resident lymphocyte T cell types in non-lymphoid organs, such as the
CC       skin and gut, but also in other nonbarrier tissues like liver and
CC       kidney, and therefore may provide immediate immunological protection
CC       against reactivating infections or viral reinfection. Binds
CC       specifically to the PRDI element in the promoter of the beta-interferon
CC       gene. Drives the maturation of B-lymphocytes into Ig secreting cells.
CC       Associates with the transcriptional repressor ZNF683 to chromatin at
CC       gene promoter regions. {ECO:0000256|PIRNR:PIRNR013212}.
CC   -!- SUBUNIT: Interacts with PRMT5. Interacts with FBXO10. Interacts with
CC       FBXO11. {ECO:0000256|PIRNR:PIRNR013212}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR013212}.
CC       Cytoplasm {ECO:0000256|PIRNR:PIRNR013212}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. {ECO:0000256|PIRNR:PIRNR013212}.
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DR   AlphaFoldDB; W5KBW7; -.
DR   STRING; 7994.ENSAMXP00000005078; -.
DR   Ensembl; ENSAMXT00000005078.2; ENSAMXP00000005078.2; ENSAMXG00000004952.2.
DR   eggNOG; KOG2461; Eukaryota.
DR   GeneTree; ENSGT00940000154798; -.
DR   HOGENOM; CLU_007033_2_1_1; -.
DR   InParanoid; W5KBW7; -.
DR   OrthoDB; 2880949at2759; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000004952; Expressed in embryo and 6 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IEA:Ensembl.
DR   GO; GO:0048066; P:developmental pigmentation; IEA:Ensembl.
DR   GO; GO:0000578; P:embryonic axis specification; IEA:Ensembl.
DR   GO; GO:0048702; P:embryonic neurocranium morphogenesis; IEA:Ensembl.
DR   GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IEA:Ensembl.
DR   GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0007521; P:muscle cell fate determination; IEA:Ensembl.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0014032; P:neural crest cell development; IEA:Ensembl.
DR   GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR   GO; GO:0051155; P:positive regulation of striated muscle cell differentiation; IEA:Ensembl.
DR   CDD; cd19187; PR-SET_PRDM1; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR016608; PRDM1.
DR   InterPro; IPR044413; PRDM1_PR-SET.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR16515; PR DOMAIN ZINC FINGER PROTEIN; 1.
DR   PANTHER; PTHR16515:SF26; PR DOMAIN ZINC FINGER PROTEIN 1; 1.
DR   Pfam; PF21549; PRDM2_PR; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   PIRSF; PIRSF013212; PRDM1; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00042}.
FT   DOMAIN          81..197
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          512..539
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          540..567
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          568..595
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   DOMAIN          596..623
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50157"
FT   REGION          300..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          422..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..314
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        315..333
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        457..475
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   755 AA;  85399 MW;  463B40773ACA69BD CRC64;
     MCGWNQSLSA ASQHSSVMLT TEEAPHTADQ VDAKMNVEDA DMSKWTEAEF EEKCTYIVKD
     HTWENPQDKP ELTRAQASLP RNLAFRHSSD SKEVIGVVSR EYIPKGTRFG PLVGEKYTAE
     NVPKDANRKY FWRIYTEGEF HHFVDGLDEE RSNWMRYVNP AHSQEEQNLA ACQNGMNIYF
     YTVKAIPADQ ELLVWYCSDF AQRLHYPLSG DLMMQKLKQS LVEAKQQASE EMPVVKREYT
     VSEILKDTWK VPARPLPTRP HCQYSPDRPI YPRVIYPIRP QPHHIREEFL KASTAICFAT
     RSPGQSSSTP SPPARSSPES SPQSSPAPRD PRDLPALPYS ASLGHYPGFS PPTPISSFYP
     NPHYILSHYS MNGAPPVGSV FPRMYPFING LLPPHMPHPS AMLPPEGGRN LLLPPPYRDL
     LIPPPKSAFP QATTPKDKPL HGHGHPHVPA SGSPTAGCAA SPDQQPANPT SAQPSAGRLE
     DEEIRLSKMK RGPAGYKTLP YPLKKQNGKI KYECNVCSKT FGQLSNLKVH LRVHSGERPF
     KCQTCNKGFT QLAHLQKHYL VHTGEKPHEC QVCHKRFSST SNLKTHLRLH SGEKPYQCKL
     CPAKFTQFVH LKLHKRLHTR ERPHKCPHCH RNYIHLCSLR LHLKGYCLAA MPSPCCSLDE
     LNRINEEIER FDISDHADRL EEIEGVDVER LVEKQILSLL FSREMDLKSS YHKGSDLLGP
     HLSSSYGLYE PSSETSVIKL LPVKVKQETV EAMEP
//
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