ID W5KBW7_ASTMX Unreviewed; 755 AA.
AC W5KBW7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=PR domain zinc finger protein 1 {ECO:0000256|PIRNR:PIRNR013212};
DE EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR013212};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005078.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000005078.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Transcription factor that mediates a transcriptional program
CC in various innate and adaptive immune tissue-resident lymphocyte T cell
CC types such as tissue-resident memory T (Trm), natural killer (trNK) and
CC natural killer T (NKT) cells and negatively regulates gene expression
CC of proteins that promote the egress of tissue-resident T-cell
CC populations from non-lymphoid organs. Plays a role in the development,
CC retention and long-term establishment of adaptive and innate tissue-
CC resident lymphocyte T cell types in non-lymphoid organs, such as the
CC skin and gut, but also in other nonbarrier tissues like liver and
CC kidney, and therefore may provide immediate immunological protection
CC against reactivating infections or viral reinfection. Binds
CC specifically to the PRDI element in the promoter of the beta-interferon
CC gene. Drives the maturation of B-lymphocytes into Ig secreting cells.
CC Associates with the transcriptional repressor ZNF683 to chromatin at
CC gene promoter regions. {ECO:0000256|PIRNR:PIRNR013212}.
CC -!- SUBUNIT: Interacts with PRMT5. Interacts with FBXO10. Interacts with
CC FBXO11. {ECO:0000256|PIRNR:PIRNR013212}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR013212}.
CC Cytoplasm {ECO:0000256|PIRNR:PIRNR013212}.
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC superfamily. {ECO:0000256|PIRNR:PIRNR013212}.
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DR AlphaFoldDB; W5KBW7; -.
DR STRING; 7994.ENSAMXP00000005078; -.
DR Ensembl; ENSAMXT00000005078.2; ENSAMXP00000005078.2; ENSAMXG00000004952.2.
DR eggNOG; KOG2461; Eukaryota.
DR GeneTree; ENSGT00940000154798; -.
DR HOGENOM; CLU_007033_2_1_1; -.
DR InParanoid; W5KBW7; -.
DR OrthoDB; 2880949at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000004952; Expressed in embryo and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IEA:Ensembl.
DR GO; GO:0048066; P:developmental pigmentation; IEA:Ensembl.
DR GO; GO:0000578; P:embryonic axis specification; IEA:Ensembl.
DR GO; GO:0048702; P:embryonic neurocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IEA:Ensembl.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0007521; P:muscle cell fate determination; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0014032; P:neural crest cell development; IEA:Ensembl.
DR GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0051155; P:positive regulation of striated muscle cell differentiation; IEA:Ensembl.
DR CDD; cd19187; PR-SET_PRDM1; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 4.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR016608; PRDM1.
DR InterPro; IPR044413; PRDM1_PR-SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR16515; PR DOMAIN ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR16515:SF26; PR DOMAIN ZINC FINGER PROTEIN 1; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR PIRSF; PIRSF013212; PRDM1; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 81..197
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 512..539
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 540..567
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 568..595
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 596..623
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 300..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..333
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 755 AA; 85399 MW; 463B40773ACA69BD CRC64;
MCGWNQSLSA ASQHSSVMLT TEEAPHTADQ VDAKMNVEDA DMSKWTEAEF EEKCTYIVKD
HTWENPQDKP ELTRAQASLP RNLAFRHSSD SKEVIGVVSR EYIPKGTRFG PLVGEKYTAE
NVPKDANRKY FWRIYTEGEF HHFVDGLDEE RSNWMRYVNP AHSQEEQNLA ACQNGMNIYF
YTVKAIPADQ ELLVWYCSDF AQRLHYPLSG DLMMQKLKQS LVEAKQQASE EMPVVKREYT
VSEILKDTWK VPARPLPTRP HCQYSPDRPI YPRVIYPIRP QPHHIREEFL KASTAICFAT
RSPGQSSSTP SPPARSSPES SPQSSPAPRD PRDLPALPYS ASLGHYPGFS PPTPISSFYP
NPHYILSHYS MNGAPPVGSV FPRMYPFING LLPPHMPHPS AMLPPEGGRN LLLPPPYRDL
LIPPPKSAFP QATTPKDKPL HGHGHPHVPA SGSPTAGCAA SPDQQPANPT SAQPSAGRLE
DEEIRLSKMK RGPAGYKTLP YPLKKQNGKI KYECNVCSKT FGQLSNLKVH LRVHSGERPF
KCQTCNKGFT QLAHLQKHYL VHTGEKPHEC QVCHKRFSST SNLKTHLRLH SGEKPYQCKL
CPAKFTQFVH LKLHKRLHTR ERPHKCPHCH RNYIHLCSLR LHLKGYCLAA MPSPCCSLDE
LNRINEEIER FDISDHADRL EEIEGVDVER LVEKQILSLL FSREMDLKSS YHKGSDLLGP
HLSSSYGLYE PSSETSVIKL LPVKVKQETV EAMEP
//