ID   W5KCT2_ASTMX            Unreviewed;      1500 AA.
AC   W5KCT2;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Disco-interacting protein 2 homolog Ca {ECO:0000313|Ensembl:ENSAMXP00000005393.2};
GN   Name=DIP2C {ECO:0000313|Ensembl:ENSAMXP00000005393.2};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005393.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000005393.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DIP2 family.
CC       {ECO:0000256|ARBA:ARBA00007735}.
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DR   STRING; 7994.ENSAMXP00000005393; -.
DR   Ensembl; ENSAMXT00000005393.2; ENSAMXP00000005393.2; ENSAMXG00000005269.2.
DR   eggNOG; KOG3628; Eukaryota.
DR   GeneTree; ENSGT00950000182997; -.
DR   HOGENOM; CLU_001345_0_0_1; -.
DR   InParanoid; W5KCT2; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000005269; Expressed in brain and 13 other cell types or tissues.
DR   CDD; cd05905; Dip2; 2.
DR   Gene3D; 3.30.300.30; -; 2.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR037337; Dip2-like_dom.
DR   InterPro; IPR010506; DMAP1-bd.
DR   PANTHER; PTHR22754; DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED; 1.
DR   PANTHER; PTHR22754:SF33; DISCO-INTERACTING PROTEIN 2 HOMOLOG C; 1.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF06464; DMAP_binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR   PROSITE; PS51912; DMAP1_BIND; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN          1..67
FT                   /note="DMAP1-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51912"
FT   REGION          1..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          114..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          162..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..59
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..102
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..178
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1500 AA;  164348 MW;  31561782954855A9 CRC64;
     LEASMAHERR PPMGPSSASR YHRRRSSGTR DERYRSDVHT EAVQAALAKH KERKVAVPMP
     SKRRSLVVQT SMDAYTPPDT SSGSEEEGGQ GEGTPTSSQG SVSMDHWISR AIHQGSTTSS
     SSSSTQSGGS GAAGRLADVL AQTHVKNHSA PPDVTTYTSE HPVQVERPQV STVPRTTPKY
     GNAELMETGD GVPVSSRVSA KIQQLVNTLK QPRRPPLREF FVDDFEELLE VQQPDPNQPR
     PEGAQMLTMR GDQLGVVTNW PPSLEAALQR WGTISPKAPC LTTMDTNGKP LYVLTYGKLW
     SRSIKVAYNI LHKLGTKQEP MVRPGDRVAL VFPNNDPAAF MVAFYGCLLA EVVPVPIEVP
     LTRKDAGSQQ IGFLLGSCGV TVALTSDACH KGLPKGPTGE IPQFKGWPKL LWFVTESKHL
     SKPPRDWFPH IKDANNDTAY IEYKTCKDGS VLGVTVMRIA LLTHCQALTQ SCGYTEAETI
     VNVLDFKKDV GLWHGILTSV MNMMHVISIP YSLMKVNPLS WIQKVCQYKA KVACVKSRDM
     HWALVAHRDQ RDINLSSLRM LVVADGSNPW SISSCDAFLN VFQSKGLRPE VICPCASSPE
     ALTVAIRRPT DDSNQPPGRG VLSMQGLSHG VIRVDTEERL SVLTVQDVGT VMPGALMCVV
     KPEGVPQLCR TDEIGELCVC SVATGTSYYG LSGMTKNTFE VFPMSNSGAP ISEYPFTRTG
     LLGFVGPGGL VFIAGKMDGL MVVSGRRHNA DDIVATALAV EPMKFVYRGR IAVFSVTVLH
     DERIVVVAEQ RPDSTEEDSF QWMSRVLQAI DSIHNVGVFC LALVPANTLP KTPLGGIHLS
     ETKQLFLEGS LHPCNVLMCP HTCVTNLPKP RQKQPEIGPA SVMVGNLVSG KRIAQASGRD
     LGQIEDNDQA RKFLFLSEVL QWRAQTTPDH VLFTLLSSRG AILSSLTCLQ LHKRAEKIAA
     MLMERGHLQD GDHVALVYPP GIDLIAAFYG CLYAGCVPIT VRPPHPQNIA TTLPTVKMIV
     EVSRSACVMT TQVICKLLKS KEASAAVDVR TWPPVLDTDD LPKKKPPQLY KPSNPDTLAY
     LDFSVSTTGM LAGVKMSHSA TSAFCRSIKL QCELYPSREV AICLDPYCGL GFVLWCLCSV
     YSGHQSILIP PSELEVNPAL WLLAVSQFRV RDTFCSYSVM ELCTKGLGLQ TESLKSRGLD
     LSRVRTCVVV AEERPRIALT QSFSKLFKDL GLHPRAVSTS FGCRVNLAIC LQGTSGPDPT
     TVYVDMRALR HDRVRLVERG SPHSLPLMES GKILPGVRII IANPETKGPL GDSHLGEIWV
     HSGHNGSGYF TVYGDEALQS DHFNSRLSFG DTQTVWARTG YLGFLRRTEL TDASGERHDA
     LYVVGALDEA MELRGMRYHP IDIETSVIRA HKSIMECAVF PWTNLLVVVV ELEGSEQEAL
     DLVPLVTNAV LEEHYLIVGV VVVVDVGVIP INSRGEKQRM HLRDGFLADQ LDPIYVAYNM
//