ID W5KDG9_ASTMX Unreviewed; 512 AA.
AC W5KDG9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=AIG1-type G domain-containing protein {ECO:0000259|PROSITE:PS51720};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005630.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000005630.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC IAN subfamily. {ECO:0000256|ARBA:ARBA00008535}.
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DR AlphaFoldDB; W5KDG9; -.
DR Ensembl; ENSAMXT00000005630.2; ENSAMXP00000005630.2; ENSAMXG00000005496.2.
DR GeneTree; ENSGT00940000162556; -.
DR HOGENOM; CLU_010468_5_3_1; -.
DR InParanoid; W5KDG9; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000005496; Expressed in pharyngeal gill and 4 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd01852; AIG1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006703; G_AIG1.
DR InterPro; IPR045058; GIMA/IAN/Toc.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10903:SF192; GTPASE IMAP FAMILY MEMBER 4-LIKE-RELATED; 1.
DR PANTHER; PTHR10903; GTPASE, IMAP FAMILY MEMBER-RELATED; 1.
DR Pfam; PF04548; AIG1; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51720; G_AIG1; 2.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 20..219
FT /note="AIG1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51720"
FT DOMAIN 254..455
FT /note="AIG1-type G"
FT /evidence="ECO:0000259|PROSITE:PS51720"
SQ SEQUENCE 512 AA; 57957 MW; CD39D7E92D56716F CRC64;
MTEAHGLQGS ESAPEGAHHL TEMKILLLGN KASGKSASIR TILGSKEPDV KTAQCVKIQG
ESAGVEVTVV EAPGWWRNYT VKDGPNLNAE EIVLSASLCS PGPHVVLLVI RLDTHFTKTC
REALKERQGL FLSESIWSHS MVLFTFGDCL RDTTLEKHIE SEGEALQWLV KKCGNRFHVF
NNKNRNDSRQ VQELLGKIED MVKINSGGTF EVDSQLLQDF EIRRRRDEMK AMERLIRVQK
QKQDTACRTG DQPQPELRIV LVGHRHSGKS SAGNTILGSE EFELRRTSKC VMKEAKVAGR
QVTVVEAPGW WNNYCLNDSS KLTKQELLRS ASLCPPGPHV LLLVLRVDGS FTKENTNPVK
EHLELFGLRV WDYTMVLFTY GDWLGETSIE QHIESEGEAL QWLVEKCGNR YHLLNNYNRG
DSDQVTELLE QIEGIVAEND PQYYEVSSEI LEEVQKGQRT VEENANLSML KVMKNRTVLK
WLKGKVQLFN IHLFFCSLGL FVKICHKCIV LK
//
