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Database: UniProt
Entry: W5KDJ7_ASTMX
LinkDB: W5KDJ7_ASTMX
Original site: W5KDJ7_ASTMX 
ID   W5KDJ7_ASTMX            Unreviewed;      1075 AA.
AC   W5KDJ7;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   24-JAN-2024, entry version 35.
DE   SubName: Full=DENN domain containing 2B {ECO:0000313|Ensembl:ENSAMXP00000005658.2};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005658.2, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX   PubMed=25329095; DOI=10.1038/ncomms6307;
RA   McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA   Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA   Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA   Yoshizawa M., Warren W.C.;
RT   "The cavefish genome reveals candidate genes for eye loss.";
RL   Nat. Commun. 5:5307-5307(2014).
RN   [3] {ECO:0000313|Ensembl:ENSAMXP00000005658.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   AlphaFoldDB; W5KDJ7; -.
DR   Ensembl; ENSAMXT00000005658.2; ENSAMXP00000005658.2; ENSAMXG00000036346.1.
DR   eggNOG; KOG3569; Eukaryota.
DR   GeneTree; ENSGT00950000182931; -.
DR   HOGENOM; CLU_921192_0_0_1; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   Bgee; ENSAMXG00000036346; Expressed in olfactory epithelium and 14 other cell types or tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR15288; DENN DOMAIN-CONTAINING PROTEIN 2; 1.
DR   PANTHER; PTHR15288:SF5; DENN DOMAIN-CONTAINING PROTEIN 2B; 1.
DR   Pfam; PF03455; dDENN; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00800; uDENN; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT   DOMAIN          638..1037
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REGION          1..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..448
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          460..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..396
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        397..414
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        415..441
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..484
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        485..519
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        520..536
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1075 AA;  120758 MW;  1BA6C105BA0428B1 CRC64;
     LRQSQLSDTE EENVSQPGLK LRSQRNWSYK TASLRPGSSL SAEFEPQSRL TKAKSIGHLD
     KKLSIYRPTA GSAGSGGGDQ DQKENQPQEG PSAGDGLCPG PLSWSTLSLA PSAVNVSANH
     GHKRTLSLSL AGSGASAATI RKKISEWECR KEARSRMSLC LEKRPGGGSE GCPSLLSSPC
     SDKTFDFKSV RRMSTALSEC SYPETEEEDG TSDRECLRQF QKREREKRTI KNESGIFLRN
     PSARKETSAV LNRIQKIEQA LKDSPSPSPP QYLNNCYGLD KPRHKPFTIG GMDDLDSTCG
     SKRSSICSVS TEPDSCLASE KLMKFRQRFS VSSIRSENLE LPPVSAPGTP GTPVNPLPKP
     KRTFEYDANR NHRDSSPSNG LPLSSGSNTP TLPRHLKTNE GSRRSQDRES CESEDATSLP
     SSYPSSPTEN GTASTENRSR PGSKSMPEEN AYEDIIESMK ENPYEDVDLK GRGAGRKSRL
     LPDRSNDSLN RMWTSQDSKC TSPPQLPSKP SSQSLRLSGP ADRKSHRLSR LSKRHSHDDM
     LLMPQLGVLD HSLSTASDTL ASRRHRRVPK VVQRINSIYC TKRGKKRLKK LSLTNIETAS
     LRAHTQRLLK LQSILRRAPS YRTLELQLLE WQERELFEYF VVVSLKKKPT KNSYAPEVTY
     QFPKLERPTK QMREAEQRLK AIPQFCFPDA PKDWNPVSDY SSETFSFMLT GEDGSRRFGY
     CRRLLPSGKG PRLPEVYCVI SRLGCFDLFS KILDEVERRR GISAALVYPF MRSLMESPFP
     APGKTIRVKT FLPGAGNEVI ELRRPMDSRL EHVDFGSLFR CLSVRQVVRV FASLLLERRV
     IFVADKLSTL SSCVHAVVAL LYPFSWQHTF IPVLPTSMVD IVCCPTPFLV GILSSSLPKL
     KELPVEEALM VDLGTDKFIR QLDDEASLLP RKLQSALELA LEQRNDIINQ DSDSESDDEC
     NSLDSVVSEA FIRFFLETIG HYSLFLTQGE RGERIFQREA FRKSVASKSI RRFLGVFMES
     QMFAGFIQDR EMRKCRAKGL FEQRVEQYLE ELPDTEQSGV NKFLKGLGRF LHKKN
//
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