ID W5KDJ7_ASTMX Unreviewed; 1075 AA.
AC W5KDJ7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=DENN domain containing 2B {ECO:0000313|Ensembl:ENSAMXP00000005658.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005658.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000005658.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR AlphaFoldDB; W5KDJ7; -.
DR Ensembl; ENSAMXT00000005658.2; ENSAMXP00000005658.2; ENSAMXG00000036346.1.
DR eggNOG; KOG3569; Eukaryota.
DR GeneTree; ENSGT00950000182931; -.
DR HOGENOM; CLU_921192_0_0_1; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000036346; Expressed in olfactory epithelium and 14 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR15288; DENN DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR15288:SF5; DENN DOMAIN-CONTAINING PROTEIN 2B; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467}.
FT DOMAIN 638..1037
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 1..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..536
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1075 AA; 120758 MW; 1BA6C105BA0428B1 CRC64;
LRQSQLSDTE EENVSQPGLK LRSQRNWSYK TASLRPGSSL SAEFEPQSRL TKAKSIGHLD
KKLSIYRPTA GSAGSGGGDQ DQKENQPQEG PSAGDGLCPG PLSWSTLSLA PSAVNVSANH
GHKRTLSLSL AGSGASAATI RKKISEWECR KEARSRMSLC LEKRPGGGSE GCPSLLSSPC
SDKTFDFKSV RRMSTALSEC SYPETEEEDG TSDRECLRQF QKREREKRTI KNESGIFLRN
PSARKETSAV LNRIQKIEQA LKDSPSPSPP QYLNNCYGLD KPRHKPFTIG GMDDLDSTCG
SKRSSICSVS TEPDSCLASE KLMKFRQRFS VSSIRSENLE LPPVSAPGTP GTPVNPLPKP
KRTFEYDANR NHRDSSPSNG LPLSSGSNTP TLPRHLKTNE GSRRSQDRES CESEDATSLP
SSYPSSPTEN GTASTENRSR PGSKSMPEEN AYEDIIESMK ENPYEDVDLK GRGAGRKSRL
LPDRSNDSLN RMWTSQDSKC TSPPQLPSKP SSQSLRLSGP ADRKSHRLSR LSKRHSHDDM
LLMPQLGVLD HSLSTASDTL ASRRHRRVPK VVQRINSIYC TKRGKKRLKK LSLTNIETAS
LRAHTQRLLK LQSILRRAPS YRTLELQLLE WQERELFEYF VVVSLKKKPT KNSYAPEVTY
QFPKLERPTK QMREAEQRLK AIPQFCFPDA PKDWNPVSDY SSETFSFMLT GEDGSRRFGY
CRRLLPSGKG PRLPEVYCVI SRLGCFDLFS KILDEVERRR GISAALVYPF MRSLMESPFP
APGKTIRVKT FLPGAGNEVI ELRRPMDSRL EHVDFGSLFR CLSVRQVVRV FASLLLERRV
IFVADKLSTL SSCVHAVVAL LYPFSWQHTF IPVLPTSMVD IVCCPTPFLV GILSSSLPKL
KELPVEEALM VDLGTDKFIR QLDDEASLLP RKLQSALELA LEQRNDIINQ DSDSESDDEC
NSLDSVVSEA FIRFFLETIG HYSLFLTQGE RGERIFQREA FRKSVASKSI RRFLGVFMES
QMFAGFIQDR EMRKCRAKGL FEQRVEQYLE ELPDTEQSGV NKFLKGLGRF LHKKN
//