ID W5KDN7_ASTMX Unreviewed; 1110 AA.
AC W5KDN7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Tolloid-like protein 2 {ECO:0000313|Ensembl:ENSAMXP00000005698.2};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005698.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000005698.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR AlphaFoldDB; W5KDN7; -.
DR STRING; 7994.ENSAMXP00000005698; -.
DR Ensembl; ENSAMXT00000005698.2; ENSAMXP00000005698.2; ENSAMXG00000005561.2.
DR eggNOG; KOG3627; Eukaryota.
DR eggNOG; KOG3714; Eukaryota.
DR GeneTree; ENSGT01030000234528; -.
DR HOGENOM; CLU_005200_0_0_1; -.
DR InParanoid; W5KDN7; -.
DR OrthoDB; 4629979at2759; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000005561; Expressed in intestine and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 6.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 6.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24255; COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED; 1.
DR PANTHER; PTHR24255:SF31; CUB DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00431; CUB; 6.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00042; CUB; 6.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 6.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS01180; CUB; 6.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Sushi {ECO:0000256|ARBA:ARBA00022659};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 54..164
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 175..288
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 325..436
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 447..562
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 602..855
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 866..976
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 987..1097
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 42..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1110 AA; 121326 MW; 0DAC4AA8005EBEC4 CRC64;
MASGKGLTTL EKCLTVLFVC LSLVCIGLIT VYALEMNKNS KDKNDGEEVL SSGCGSPGQL
SGDSGEFSSR NYPNHYKDDM SCRWNITVER RKVIHLWFED FSLEYSTSCS ADALTLRDNV
GLIGTYCGQS VPKPIVSLGN SLVVHFDTNH IHAYRGFRAM YRAVNPESVT EIVGAGGILV
SGTGELMTLG FPEQNYDLGV IYQWRIEVLP QETVRLTFLD FDLDPYSCED YVDVFDGYSD
GVSAIKLGHF CGNKVPEPVV SHSGGMVVRF KSDFAYSAKG FRAVYTAVPP VTPTISPASP
TTITTATLNT TITTSTTVGP IDSGCGSPGT QSGRKGEIHS LGFPDTYPAN LQCSWNISVA
EGLLIKLHIT DLAIVGEAGQ CGGDKLTVSD SQQSLGTHCG FILPPVLVSV SNRMSLSFQS
DGRLADRGFS ARWEAVYPED IAEVQGCGGF SREETGVIKS ENWPMNYPPN RECLWRVQVP
QGKTITLTFT QFDVEEAGLL LGRCFDNVVI YDGSQPTAKK YGPYCGTNIP PVIQTTGNEL
VMRFFADFFT EAEGFRAFWT TDPTLPAPTE PPVPPNPWDN IHIEWPETCG RPAIPPTVNT
RIVNGEPAKA HSWPWQVSMQ VWPESQPTPT FFHTCGGTLI HKQWVLTAAH CFIRYADELQ
RWQMCLGKYN LTLSEPSQQC FGVLGIYRHE GFKYPTVPTV EFDVALVRLD GEVTPSDQVH
FACMPPVEQV LPGGTKCYAT GWGDETGNFT APKVAETLNQ VALPVVPYDT CKRMDYWWFQ
VKSSMICAGY NAPDELRSVC QGDSGGPFVC QASPSDPWQV HGITSFGPIG CIMDKKPSVF
TRSSAYLPWI ENAMRKDVYS RLSSGCGGQK ELIGSAGSFS SMNNPQSYEN LARCQWNIIV
PAGMRVHLHF PTFSLEESQL CLNDKVSISD RVGSLGTHCS TSPPADLVSA GESLTVQFYS
NDKVVDTGFN VTWRAINPAD ISNVVGCGGE FTGQQGELQS SNWPNNYPNQ AVCTWTVSSS
SATSLHIVFT HFEVQAVNLL GKCVDFVEVF DAAGVSQGQF CGNVPPSLNI TGDKAIIRFR
TDATGQRKGF RGYWTTDPNV VPTSAPLPLK
//
