ID W5KDT9_ASTMX Unreviewed; 2159 AA.
AC W5KDT9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Fibronectin {ECO:0000256|ARBA:ARBA00020368};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000005750.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000005750.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 7994.ENSAMXP00000005750; -.
DR Ensembl; ENSAMXT00000005750.2; ENSAMXP00000005750.2; ENSAMXG00000005593.2.
DR eggNOG; ENOG502QPTS; Eukaryota.
DR GeneTree; ENSGT00940000155126; -.
DR HOGENOM; CLU_000916_0_0_1; -.
DR InParanoid; W5KDT9; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000005593; Expressed in pharyngeal gill and 14 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR GO; GO:0030325; P:adrenal gland development; IEA:Ensembl.
DR GO; GO:0003401; P:axis elongation; IEA:Ensembl.
DR GO; GO:0003319; P:cardioblast migration to the midline involved in heart rudiment formation; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0060956; P:endocardial cell differentiation; IEA:Ensembl.
DR GO; GO:0001706; P:endoderm formation; IEA:Ensembl.
DR GO; GO:0045198; P:establishment of epithelial cell apical/basal polarity; IEA:Ensembl.
DR GO; GO:0003128; P:heart field specification; IEA:Ensembl.
DR GO; GO:0003146; P:heart jogging; IEA:Ensembl.
DR GO; GO:0070309; P:lens fiber cell morphogenesis; IEA:Ensembl.
DR GO; GO:0001755; P:neural crest cell migration; IEA:Ensembl.
DR GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR GO; GO:0001757; P:somite specification; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR CDD; cd00061; FN1; 11.
DR CDD; cd00062; FN2; 2.
DR CDD; cd00063; FN3; 14.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 12.
DR Gene3D; 2.10.10.10; Fibronectin, type II, collagen-binding; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 15.
DR InterPro; IPR000083; Fibronectin_type1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR000562; FN_type2_dom.
DR InterPro; IPR036943; FN_type2_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013806; Kringle-like.
DR PANTHER; PTHR46708:SF8; FIBRONECTIN; 1.
DR PANTHER; PTHR46708; TENASCIN; 1.
DR Pfam; PF00039; fn1; 11.
DR Pfam; PF00040; fn2; 2.
DR Pfam; PF00041; fn3; 15.
DR PRINTS; PR00013; FNTYPEII.
DR SMART; SM00058; FN1; 12.
DR SMART; SM00059; FN2; 2.
DR SMART; SM00060; FN3; 15.
DR SUPFAM; SSF49265; Fibronectin type III; 9.
DR SUPFAM; SSF57603; FnI-like domain; 12.
DR SUPFAM; SSF57440; Kringle-like; 2.
DR PROSITE; PS01253; FN1_1; 4.
DR PROSITE; PS51091; FN1_2; 11.
DR PROSITE; PS51092; FN2_2; 2.
DR PROSITE; PS50853; FN3; 14.
PE 4: Predicted;
KW Acute phase {ECO:0000256|ARBA:ARBA00022486};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00479}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sulfation {ECO:0000256|ARBA:ARBA00022641}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..2159
FT /note="Fibronectin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017402660"
FT DOMAIN 30..81
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 86..129
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 130..173
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 175..219
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 220..264
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 347..395
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 407..455
FT /note="Fibronectin type-II"
FT /evidence="ECO:0000259|PROSITE:PS51092"
FT DOMAIN 460..504
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 509..551
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 552..595
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 603..702
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 708..795
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 796..887
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 894..985
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 986..1073
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1074..1161
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1162..1253
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1255..1349
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1350..1437
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1438..1531
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1532..1622
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1623..1708
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1709..1797
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1799..1886
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1980..2024
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 2025..2067
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT DOMAIN 2069..2109
FT /note="Fibronectin type-I"
FT /evidence="ECO:0000259|PROSITE:PS51091"
FT REGION 1425..1446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 352..378
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 366..393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 412..438
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
FT DISULFID 426..453
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00479"
SQ SEQUENCE 2159 AA; 238127 MW; 59F3D2ADFF62AF42 CRC64;
WVVMCVPRLI LIQVYCALTC VKGSESRKQV RCVDNAVEFS ADGCVEYGQF YGVGEQWERM
YLGSVLVCTC NGVAGIKCKT KPEAEETCYD KVNARSYRVG ETYERPKDGM IWDCTCIGSG
RGKISCTIAN RCHEGGHSYK IGDTWRRPHD TGEYMLECVC LGNGKGEWTC KPVAERCYDN
TAGTSYVVGE TWEKPYQGWM IVDCTCLGEG SGRITCTSRN RCNDQDTRMS YRIGDTWTKT
DARGHTLQCL CTGNGRGEWK CERHASLHTT GSGSRVITNV QPAVFQPVPI PVTPVEGTCL
TDSGVSYTLG MRWIKTQGSK QMLCTCLGTG VSCEEWEGHS RVYGGNTNGQ PCVFPFVSMG
KTFYSCTSEG RSDGQLWCST TSDFEKDHKY SFCTEKNVLV TTRGGNSNGA LCQFPYLYNG
HNYTDCTADG RRDGMKWCST TYNYDGEQRF GFCPMAAHEE VCTTSEGVMY RVGDQWDKRH
DVLGHMMRCT CVGNGRGEWS CIAYSQLKDQ CIVDGLTYEV NQTFTKRHDE GYMMNCTCFG
QGRGRWKCDA IDQCQEPETR VFYQIGESWD KVIRGIHYRC HCYGNGIGEL SCEPQQSFPG
GNRPVQVIIT EAGNQPNSHP IQWNAPPSVH ITQYILKWRQ KNTNAPWREV TLPGHLNSYT
IAGLKPGITY EGQLISILRF GRREVNRFDF STTYGSLATS EGETAPPPPE IDTSESVTEI
TSSSFVISWV SASDTVSGFR VEYELTEEGD LPRTATSVNI NELLPGRKYT VNVYEVTDEG
EPNLILTTSQ TTAPDAPTDH EVEDIAETSI KVSWSRPVAP ITGYRVVYTP SVEGSSGSTE
LNLPDTATSV TLSDLRPGQL YNISIYAVEE NLESEPVFVQ VNTAGEPLPE EIPSPTDLQF
FEVSDSKITI TWTGPPTEVS GFRVSVAQVG HDGLTERETQ LPITHNAYAE IAQLQPGTLY
RFFIFALKGV EESEPLVGEQ TTKPDTPTNF RLTNVTEDSA LIIWSAPRAQ VTGYRLFLTV
EGSNTKQMRI PGRLTQYTLL NLQPDTAYTA TLHSEQGNVI SGGAVATFKT SRPMGNAPRF
STDVTDTSII ISWSPVPRIG YRLTVRPSQG GEAPREVTSE SGSIYVSGLT PGVEYTYSVQ
PVINGHGHGN PITRRVVTPL SPPTDLNLET NPNTGELTVQ WNDAKTPDIT GYRVTCTPTN
GQQGNSLEEF VKAGQTSCTL ENLSPGVEYN VSVFTVKDDM ESVPVSSTIT PAVPAPTGLA
FTNVSTDSFT VTWKAPNVPK PADIDTYIIR YHPVDDEDDI TERNVEGNTN SVVLRHLLPN
TEYFVSVFCV YEERESSPVI STQRTVLDSP VGLRFSEIST NSFTVHWMPP QAIISGYRIR
YQMTSGGRSK EERLPPSRSH LTLTGLAPET EYIINIYAVS GSHESKPLTG TQSTISDAPT
DLEVTSSTPD SITIRWDAPS VTVRYYRITH GESGGHGSPV EFTVPGSQTT ATIQGLRPGT
DYTVTVYAVT GRGDSPASST PIHVNHKTDI ESPSEMEVTD VKDSTITVRW TPAVGPVSGY
RITGTPRNGQ GPTFSEVVAP DQTEITFSGL MPTAEYTLSV YALGQDGESP PLVETVVTTI
PGPSDLQFSQ IGSSSFTVSW YSAANVQLTG YRVAITPKNK NGPTKEVHIA PDSTQYHATG
LMPATDYEVE VYAVKNSLTS QKLLVYISPP RRVRISNVKD SSVTLTWRSK TEAISGFLVE
ATPTIGGESP IQRTIPSDSR TYTITGLQPG TNYKINIYTL NGNSRSEPFT LTATTVISPP
TNIRFTSLTP TTISFSWEPP RSTITGYYIT YEEAGSIPRE LLPRPLAVRT SATITGLKPG
TEYIIRIVAL NNAQRSTPLL GKTDLPQEAQ TQTTITWQPV EHSDEYVVSC SPITEINEKT
FQMHLPGSSN SATLIGLTSG ASYNIVVESV NGDHKQKVLQ DVVTVGNTFP GPSAIPIGRD
VCYDTFTATY HEVGTEWERM SETGFKLWCR CLGLGSGHFR CDSSKWCHDN GHNYRIGERW
DRRAENGHMM SCTCLGNGKG EFKCEPHEST CYDEGKMYQV GNQWQKEYLG AICTCTCYGG
QQGWRCENCR RPGAEVNVDL IQPPIHTDVY DRYRENALRK LVSVVNSRKE LVLCVRYHT
//
