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Database: UniProt
Entry: W5KFP0_ASTMX
LinkDB: W5KFP0_ASTMX
Original site: W5KFP0_ASTMX 
ID   W5KFP0_ASTMX            Unreviewed;      1789 AA.
AC   W5KFP0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   28-MAR-2018, entry version 30.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC   Characoidei; Characidae; Characidae incertae sedis; Astyanax clade;
OC   Astyanax.
OX   NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006401, ECO:0000313|Proteomes:UP000018467};
RN   [1] {ECO:0000313|Ensembl:ENSAMXP00000006401, ECO:0000313|Proteomes:UP000018467}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=female {ECO:0000313|Ensembl:ENSAMXP00000006401};
RA   Jeffery W., Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSAMXP00000006401}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; APWO01055215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01055216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01055217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01055218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01055219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01055220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01055221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01055222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01055223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; APWO01055224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMXT00000006401; ENSAMXP00000006401; ENSAMXG00000006225.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000018467; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005244; F:voltage-gated ion channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR028817; Na_channel_a4suB.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF186; PTHR10037:SF186; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018467};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00085096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084820};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000256|SAAS:SAAS00084701};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    131    150       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    195    214       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    226    247       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    399    426       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    560    587       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    599    622       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    679    707       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    769    792       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    976    994       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1015   1037       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1043   1063       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1092   1118       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1216   1240       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1299   1317       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1329   1351       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1363   1382       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1426   1452       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1517   1543       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      132    433       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      570    796       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      805    969       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      974   1248       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1298   1552       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       29     49       {ECO:0000256|SAM:Coils}.
FT   COILED      423    457       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1789 AA;  202962 MW;  CD212E316FCCBE11 CRC64;
     MACLLPPTGT DVFRRFTPET LVEIERRMVE EASEQERKKA LNIEVAEEDL PKPSSDLEAG
     KSLPFIYGDP PPELLNVPLE DLDPYYKAQK TFIVISKGNT INRFNAESAC YILNPFSPVR
     RGAIRILIHS YPLNMFIMVT ILSNCVFMTM SNPPEWSKIM EYVFTGIYTF EALIKVLSRG
     FCIGDFTFLR DPWNWLDFMV ISMAYLTEFV DLGNVSALRT FRVLRALKTI TVIPGLKTIV
     GALIQSVKKL ADVMILTVFC LSVFALIGLQ LFMGNLRQKC VVWPPVFPLI NGTTNMNATA
     SFSDKLYANS SFDYEEYINN EENYYFIPGS MDALLCGNSS DSGRCPEGYM CLKAGRNPNY
     GYTSYDNFGW AFLALFRLMT QDFWENLFQL TLRSAGKTYM IFFVVIIFLG SFYLINLILA
     VVAMAYAEQN EATKAEAKAK EEEYEIMLEQ LRKHAEQKKG MANGSCTSLS SKKKDDDGGG
     RVKTQHDSIA LKEVSKLNGS KASMNHLDVT NGHNRKPSVA GSAIDELEEL ERPCPPCWYT
     FADIFLKWDC CTPWIRFKKF VYFIVMDPFV DLGITICIVL NTVFMAMEHY PMTAEFESVL
     SVGNLVFTGI FTAEMVLKLI AMDPYYYFQV GWNIFDSIIV TMSLVELGLA NVEGLSVLRS
     FRLMRVFKLA KSWPTLNMLI KIIGNSVGAL GNLTLVLAII VFIFAVVGMQ LFAGSYKSCV
     CKISEDCELP RWHMTDFFHS FLIVFRILCG EWIETMWDCM EVAGQGMCIV VFMMVMVIGN
     LVVLNLFLAL LLSSFSGDNM ASDDDGEMNN LQIAIGRITR AVDWVKATVT GQARSVLGLK
     PVEKEKKGND EDDFRCNNDL VLTHMESGVK VPMAKRESDF ESPYDDTSDD EDKKADEKSK
     LKDSGGDDSS CSTVDKPPEV EEAESEEEED PTTPEDCYTE KCIRRCPCLD LDITQGRGKS
     WWAFRKTCFL IVEHNYFETF IIFMILLSSG ALAFEDIYLE QRRTIKIILE YADQVFTYIF
     VVEMLLKWCA YGFKTYFTNA WCWLDFLIVD VSLISLTANI LGYSELGPIK SLRTLRALRP
     LRALSRFEGM RVVVNALVGA IPSIFNVMLV CLIFWLIFSI MGVNLFAGKF YHCINTTSEE
     LFPPEVVNNK SECFLLIEGG YDARWVNQKV NYDNVGMGYL SLLQVATFKG WMDIMYAAVD
     SRNVEDQPSY EINLYMYIYF VIFIIFGSFF TLNLFIGVII DNFNQQKSKI RGQDLFMTED
     QKKYYNAMKK LGSKKPQKPI PRPQNCCQGF VFDLVTKQFF DILIMVLICL NMITMMAETD
     EQSIEVEEIL FYINFAFIVI FTGECVLKII ALRQYYFSVG WNIFDFIVVI LSILGIVLAD
     IIEKYFVSPT LFRVIRLARI GRVLRLIRGA KGIRTLLFAL MMSLPALFNI GLLLFLIMFI
     FSIFGMSNFA YVKKEMGIDD MFNFETFGNS IICLFMITTS AGWDGLLSPI LNNAPPDCDP
     DIQNPGSDVR GNCGNPAVGI VFFCTYIVIS FLVVVNMYIA IILENFNVAT EESGEPLCED
     DFEMFYETWE RFDPDASQFI AYSSLSDFCD TLKDPLRIPK PNTIKLITMD LPMVPGDKIH
     CLDILLALTA EVLGESEAMD SLKATMEEKF MANNPSKVSY EPITTTLRRK QEEVAAVVIQ
     RAYRKHVLKR TLKQASYMFR EKSDLTRKGE EPPEKVGMVA KQLSQLYGDH AVEELPPASI
     LRLQKRDIAG KARGKIPSVE VQSEVILHSA PFSAPESSAY VDNLRESIV
//
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