ID W5KFY4_ASTMX Unreviewed; 1700 AA.
AC W5KFY4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=PLAT domain-containing protein {ECO:0000259|PROSITE:PS50095};
OS Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Astyanax.
OX NCBI_TaxID=7994 {ECO:0000313|Ensembl:ENSAMXP00000006495.2, ECO:0000313|Proteomes:UP000018467};
RN [1] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RA Jeffery W., Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000018467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=female {ECO:0000313|Proteomes:UP000018467};
RX PubMed=25329095; DOI=10.1038/ncomms6307;
RA McGaugh S.E., Gross J.B., Aken B., Blin M., Borowsky R., Chalopin D.,
RA Hinaux H., Jeffery W.R., Keene A., Ma L., Minx P., Murphy D., O'Quin K.E.,
RA Retaux S., Rohner N., Searle S.M., Stahl B.A., Tabin C., Volff J.N.,
RA Yoshizawa M., Warren W.C.;
RT "The cavefish genome reveals candidate genes for eye loss.";
RL Nat. Commun. 5:5307-5307(2014).
RN [3] {ECO:0000313|Ensembl:ENSAMXP00000006495.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 7994.ENSAMXP00000006495; -.
DR Ensembl; ENSAMXT00000006495.2; ENSAMXP00000006495.2; ENSAMXG00000006274.2.
DR eggNOG; KOG3599; Eukaryota.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000164905; -.
DR HOGENOM; CLU_000913_0_0_1; -.
DR InParanoid; W5KFY4; -.
DR Proteomes; UP000018467; Unassembled WGS sequence.
DR Bgee; ENSAMXG00000006274; Expressed in testis and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF195; POLYCYSTIC KIDNEY DISEASE 1 LIKE 2A-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018467};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 609..629
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 817..837
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 857..879
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1074..1096
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1205..1227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1450..1469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1489..1506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1538..1557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1578..1600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1636..1662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 654..771
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DISULFID 1301..1314
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 1700 AA; 190220 MW; 5862FF6E6014212B CRC64;
MLLKQQASNV NIFAVPSTIL KAATQDIRVV VYGSKDGQSG YDTFIIPLSE AQSPLTCSIN
PPVGDILSPF NISCSTVNQF CCPDCCTFCL TTLDGSKLYC GSDVGMRSLF LPLGNKSSNH
SVGLRVIVKN ANGRTTNTTL STQVRDAGSN STIQDLRTLV SQYVTQLNGS SSASVLAQMF
LSVSTNLNKD LSNKEEKKKL REEMLGHMCD AMTAGEPLVV LTEAETTANT VFSLVTLKDE
ITTNAEMNAC CVLNKVSTSL TSTSHTEGDD SALMMQVATP IFQAAGIILE VSANSDKQSE
ISSTILKITE NIQSALLANK QPNREPLILT SPLISMYVNR LSPDRLHNQI FSIDKNSSAF
TLPLLGPQML HSDKPVDVRM LSFGMNPFSW SKGDAISGAV GGLSLTREDG SVIPVSNLNK
EIEILLPRLE AVDLNSTVLD LSKYSTLAIN LTNPNTSLVL KLDPSEEIAL QLSLGFKYYP
NDTHYKAKIQ LPLHKTTPEE RYTWVIDSKD GALEAGLYYL LVRPIVGAGV NSSNASVIIS
SIAAQCKYWD NIKTNWSDYG CRVGPGTTRL VTQCLCTHLT FFGSSFFVMP NAVDVTRTAE
LFATFSQNPV VVCFVGAVFL LYFITVVWAR RKDLQDQVKV KVTVLEDNDP LAEYRYLLVI
STGHRRGAST SSQVTVTVTG SVWESEPHHL TDPDKPVFER GGVDMFLLST PFNLGDLQSI
RLWHDNSGTH PAWYVNKVMV QDLENGQKWH FLCSSWLAID MGECTLDKVF SLATETDLKR
FSNLFFMKTA KDLFDGHLWF SVISRPANSR FTRVQRVSCC FSLLLGTMLT GIMFWGIPSD
PSEQSVTIGS IKFSWRQLMV GIQSSIIMFP VNLLIVSIFR LARPRKKTQQ TASDQIPKLE
SALEDKKHSI ALPQGCLRTD ITVEYVIKDI KRILGSLAKA VGCPVPKTAL ESGITDIFTL
LSLIEEIIQQ QNSTLRRFDI EDSHNNLVSV YKLYQQHLYK QLQNLEKELK LIGPSEISDP
EIYSRAVLQV QRMKGLLEAH LSSTSSKLQL TCISSPAGSS GASKKKCCQK GLPWWFVFVG
WFLIAATSGV SAYFTMMYGL TYGKEKSISW LISLSVSFFQ SLLLIQPVKV LGFAVFFALV
VKSVDDDDED DEEYIKMLKN KVPAFSGDPD DVRISRRNSS CSFYQPPPPS DVGKMKEIWI
KDQKAFALIW EILIYLGFFC MLLMAAYSQR DPNAFFLTRH IQQSFSNGIS DSMSQQDVFI
WANSSLLTNL FGQYSGFITD GNSKLVGTAR LRQVRVQKSS CRKASSVRSS VPDCHAPYSW
EVEDMGSYGP GWTSLIDSNM SKALFTPWQY QTQSRLRAHT VWGGMALYRG GGFVVDLEPD
QQNSSSVLQY LFENAWLDIY TRALFIEFTV YNANVNLFCI VTLMLETTAV GAFQYRTELQ
NIRLFQTTDG IPTLVSEAIY FLFILYYMFL QAKLMKQQKW EYFRNKWNIL ELAIILLSWS
AFSVFIKKMV QGDQDLKYYQ DHRNQFPSFY ETAAADSVLG YLTAVLVLLA TIKMWHLMRL
NSKLNMITNT LQQAWSDISS FIVVIVIMFL AYSIVSNLLF GWKLYTYKTL IDAATAMVSL
QLGIFNYEEI LDLNPVLGAF IIGSCIIFMT FVVLNLFISV ILEAFSQEQR HHKPSEEEEI
VDLMLLKICN FLGIKTKKKQ
//
